Research field (1)：
Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (6)：
2024 - 2027 Biodistribution control of IgG by selective inhibition of FcRn interaction
2022 - 2025 Catalytic activity regulation system with a bispecific metallopeptide
2023 - 2024 Temporary production of toxin for cancer stem cell treatment
2020 - 2023 ペプチドを用いた触媒活性制御機構の開発
2019 - 2022 Fc 受容体への親和性改変を指向した生体内抗体修飾反応の開発
2015 - 2018 難修飾性抗がん剤の標的指向化に資する新規抗体修飾ペプチドの創製
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Papers (25)：
Kyosuke Imai, Kyohei Muguruma, Akiko Nakamura, Yuriko Kusakari, Tsung-Che Chang, Ambara R. Pradipta, Katsunori Tanaka. In vivo synthetic anticancer approach by resourcing mouse blood albumin as a biocompatible artificial metalloenzyme. Angewandte Chemie International Edition. 2024
Kyohei Muguruma, Akane Fukuda, Hayate Shida, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi. Structure Derivatization of IgG-Binding Peptides and Analysis of Their Secondary Structure by Circular Dichroism Spectroscopy. Chemical & pharmaceutical bulletin. 2024. 72. 9. 831-837
Minagi Mukaiyama, Chihiro Uchiyama, Akane Fukuda, Yoshiki Nakazawa, Yuka Kuramochi, Yudai Shibata, Sho Konno, Kyohei Muguruma, Naohiro Matsugaki, Tomo Asari, et al. X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener. Journal of medicinal chemistry. 2023. 66. 13. 8717-8724
Yudai Ode, Ambara R. Pradipta, Peni Ahmadi, Akihiro Ishiwata, Akiko Nakamura, Yasuko Egawa, Yuriko Kusakari, Kyohei Muguruma, Yang Wang, Xiaojie Yin, et al. Therapeutic efficacy of 211At-radiolabeled 2,6-diisopropylphenyl azide in mouse models of human lung cancer. Chemical Science. 2023. 14. 30. 8054-8060
Tsung-Che Chang, Igor Nasibullin, Kyohei Muguruma, Yuriko Kusakari, Taiji Shimoda, Katsunori Tanaka. Evaluation of acute toxicity of cancer-targeting albumin-based artificial metalloenzymes. Bioorganic & Medicinal Chemistry. 2022. 73. 117005-117010
