Tsuchikawa Hiroshi

ツチカワヒロシ | Tsuchikawa Hiroshi

Affiliation and department：
Job title： Specially Appointed Lecturer

Research field (3)： Pharmaceuticals - chemistry and drug development , Molecular biochemistry , Synthetic organic chemistry

Research keywords (5)： natural product synthesis , molecular probe , chemical synthesis , lipid bilayer , Small Molecule Drug Discovery

Research theme for competitive and other funds (7)：

2021 - 2025 Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions
2020 - 2023 新規活性物質の創出に向けた天然物活性中心骨格を起点とするタンパク質の機能制御
2017 - 2022 Dynamic conformation and domain structure of lipid molecules in model biomembranes
2016 - 2021 Dynamic conformation and domain structure of lipid molecules in model biomembranes
2015 - 2018 Structural analysis of bafilomycin bound to V-ATPase for elucidating its inhibition mechanism based on synthetic chemistry

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Papers (60)：

Yuichi Umegawa, Takeshi Shimonishi, Hiroshi Tsuchikawa, Michio Murata. LnDOTA -d ₈ , a versatile chemical-shift thermometer for ² H solid-state NMR. Magnetic Resonance in Chemistry. 2022
Yuichi Umegawa, Tomoya Yamamoto, Mayank Dixit, Kosuke Funahashi, Sangjae Seo, Yasuo Nakagawa, Taiga Suzuki, Shigeru Matsuoka, Hiroshi Tsuchikawa, Shinya Hanashima, et al. Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study. Science advances. 2022. 8. 24. eabo2658
Hiroshi Tsuchikawa, Mami Monji, Yuichi Umegawa, Tomokazu Yasuda, J Peter Slotte, Michio Murata. Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers. Langmuir : the ACS journal of surfaces and colloids. 2022. 38. 18. 5515-5524
Shinya Hanashima, Ryuji Ikeda, Yuki Matsubara, Tomokazu Yasuda, Hiroshi Tsuchikawa, J. Peter Slotte, Michio Murata. Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers. Biophysical Journal. 2022. 121. 7. 1143-1155
Hiroshi Tsuchikawa, Takuya Ono, Masaki Yamagami, Yuichi Umegawa, Wataru Shinoda, Michio Murata. Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine. Biochemistry. 2020

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MISC (24)：

KEERATISAKULSITH Tanatchphong, UMEGAWA Yuichi, TSUCHIKAWA Hiroshi, HANASHIMA Shinya, MURATA Michio, SHINODA Wataru. Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR. 日本化学会春季年会講演予稿集(Web). 2021. 101st
村田道雄, 梅川雄一, 花島慎弥, 土川博史. Natural products and membrane lipids interplay responsible for biological activities. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
大田英和, 梅川雄一, 花島慎弥, 土川博史, 村田道雄. Evaluation of membrane functions of polyunsaturated fatty acid-substituted phospholipids based on solid-state-NMR. 日本化学会春季年会講演予稿集(Web). 2021. 101st
井端悠貴, 花島慎弥, 安田智一, 安田智一, 土川博史, 村田道雄. 新規コレステロール側鎖重水素標識体の開発とそれを用いた三成分膜での相状態の解明. 日本化学会春季年会講演予稿集(CD-ROM). 2019. 99th
山本智也, 山本智也, 梅川雄一, 梅川雄一, 中川泰男, 鈴木大河, 山上正輝, 土川博史, 花島慎弥, 村田道雄, et al. Structure Elucidation of Ion Channel Assembly Formed by Amphotericin B and Sterol. 天然有機化合物討論会講演要旨集(Web). 2018. 60th

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Education (3)：

Professional career (1)：

Work history (5)：

2019/06 - 2020/04 Oita University Research Promotion Institute Visiting Researcher
2010/06 - 2019/05 Osaka University Graduate School of Science Department of Chemistry Assistant professor
2009/04 - 2010/05 RIKEN Post Doctoral Researcher
2007/01 - 2009/03 Kwansei Gakuin University School of Science and Technology Department of Chemistry Post Doctoral Fellow
2003/04 - 2006/03 Japan Society for the Promotion of Science JSPS Research Fellowship for Young Scientists (DC1)

Committee career (1)：

Awards (1)：

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