Okiyoneda Tsukasa

Affiliation and department：

Research field (2)： Pharmacology , Functional biochemistry

Research keywords (4)：治療薬 , ユビキチン , 嚢胞性線維症 , タンパク質品質管理

Research theme for competitive and other funds (11)：

2022 - 2025 哺乳類 ERAD における逆輸送機構の包括的理解
2021 - 2023 CFTR ユビキチン化制御剤の創出と CF 創薬への応用
2019 - 2022 Elucidation and therapeutic application of ubiquitination mechanisms in the PMQC
2019 - 2021 RFFL による形質膜タンパク質品質管理作動機構の解明と CF 創薬への応用
2018 - 2021 AI-based drug discovery approach based on biomedical big data and its application to refractory diseases

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Papers (42)：

Daichi Hinata, Ryosuke Fukuda, Tsukasa Okiyoneda. The COPD-Associated Polymorphism Impairs the CFTR Function to Suppress Excessive IL-8 Production upon Environmental Pathogen Exposure. International journal of molecular sciences. 2023. 24. 3
Shogo Taniguchi, Yukiko Ito, Hibiki Kiritani, Asuka Maruo, Ryohei Sakai, Yuji Ono, Ryosuke Fukuda, Tsukasa Okiyoneda. The Ubiquitin Ligase RNF34 Participates in the Peripheral Quality Control of CFTR (RNF34 Role in CFTR PeriQC). Frontiers in molecular biosciences. 2022. 9. 840649-840649
Ryosuke Fukuda, Tsukasa Okiyoneda. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis. Pharmaceuticals (Basel, Switzerland). 2020. 13. 4
Yuka Kamada, Ryosuke Fukuda, Tsukasa Okiyoneda. ELISA Based Protein Ubiquitylation Measurement. Bio-protocol. 2019. 9. 22. e3430
Sakai R, Fukuda R, Unida S, Aki M, Ono Y, Endo A, Kusumi S, Koga D, Fukushima T, Komada M, et al. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors. J. Cell Sci. 2019. 132. pii: jcs228007

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MISC (71)：

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Patents (2)：

Education (3)：

Work history (7)：

2019 - 現在関西学院大学理工学部生命医化学科教授
2015/04 - 現在 Kwansei Gakuin University School of Science and Technology, Department of Biomedical Chemistry
2013/04 - 2015/03 Kwansei Gakuin University School of Science and Technology, Department of Bioscience
2008/06 - 2013/03 McGill University
2006/04 - 2008/05 Hospital for Sick Children Research Institute Program in Cell Biology

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Committee career (1)：

Awards (17)：

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Association Membership(s) (3)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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