Rchr
J-GLOBAL ID：201801007619202565   Update date: May. 12, 2024

Endo Akinori

エンドウ アキノリ | Endo Akinori
Affiliation and department：
Tokyo Metropolitan Institute of Medical Science

About Tokyo Metropolitan Institute of Medical Science


Research field  (1)： Molecular biology
Research theme for competitive and other funds  (4)：
  • 2020 - 2023 ユビキチン非依存的プロテアソーム分解機構の解析
  • 2018 - 2020 A deubiquitylating enzyme USP8 is required for glucocorticoid receptor activation
  • 2010 - 2011 リボソーム生合成を制御する脱ユビキチン化酵素USP36の増殖因子による活性調節
  • 乳腺に特異的に発現するNrkが乳がんを抑制する分子機構の解明~画期的乳がん治療法を目指した基盤研究~
Papers (34)：
  • Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
  • Takumi Ito, Tomoko Asatsuma-Okumura, Akinori Endo, Junichi Yamamoto, Yoshiko Iwai, Yuki Yamaguchi, Mikihiko Naito, Hiroshi Handa, Yasushi Saeki. ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugs. 2023
  • 中臺 航太, 遠藤 彬則, 冨田 拓哉, 柴田 識人, 出水 庸介, 有竹 浩介, 佐伯 泰. PROTACが誘導するユビキチン化ゾーンと補助因子の解析. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-148]
  • Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
  • Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, et al. An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants. Frontiers in Microbiology. 2022. 13. 967019-967019
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MISC (6)：
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Lectures and oral presentations  (5)：
  • RAD23B drives polyubiquitin chain-dependent phase separation of the proteasome
    (2020)
  • 脱ユビキチン化酵素USP8によるエンドソームストレス制御
    (第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会合同年次大会 2019)
  • Dynamic proteome remodeling by oncogene activation revealed by comprehensive analyses of protein abundance and turnover
    (American Society for Mass Spectrometry Annual Conference 2018)
  • 脱ユビキチン化酵素USP8によるコラーゲン分泌経路の制御
    (ConBio2017 2017)
  • 遺伝子変異による脱ユビキチン化酵素USP8の細胞質から核への局在変化とCushing病
    (第39回 日本分子生物学会大会 2016)
Work history (2)：
  • 2015/10 - 2018/12 Tokyo Institute of Technology
  • 2011/04 - 2015/09 Dundee University Research Associate
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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