Wiriyasermkul Pattama

Affiliation and department：
Job title： Associate Professor

Research field (9)： Functional biochemistry , Structural biochemistry , Molecular biology , Functional biochemistry , Applied molecular and cellular biology , Systems genomics , Food sciences , Nutrition and health science , Pharmacology

Research keywords (8)： Biochemistry , Molecular Biology , Structural Biochemistry , Molecular Nutrition , Applied Biochemistry , Bioinformatics , Medical Science , Molecular Pharmacology

Research theme for competitive and other funds (3)：

2022 - 2025 Molecular mechanism of amino acid harmonization: a paradigm of heterodimeric amino acid transporters
2021 - 2024 階層的アプローチによる膜輸送体の隠されている生理的基質の解明
2019 - 2022 Molecular mechanism of the pathogenic protein interaction at the C-terminus of amino acid transporter b0,+AT/SLC7A9 in Japanese-type cystinuria

Papers (38)：

Saishu Yoshida, Akira Kawamura, Katsuhiko Aoki, Pattama Wiriyasermkul, Shinya Sugimoto, Junnosuke Tomiyoshi, Ayasa Tajima, Yamato Ishida, Yohei Katoh, Takehiro Tsukada, et al. Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 28. e2320070121
Pattama Wiriyasermkul, Satomi Moriyama, Masataka Suzuki, Pornparn Kongpracha, Nodoka Nakamae, Saki Takeshita, Yoko Tanaka, Akina Matsuda, Masaki Miyasaka, Kenji Hamase, et al. A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters. eLife. 2024. 12. RP92615
Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, et al. Identification of three distinct cell populations for urate excretion in human kidneys. The Journal of Physiological Sciences. 2024. 74. 1
Jun Weng, Xiaoming Zhou, Pattama Wiriyasermkul, Zhenning Ren, Kehan Chen, Eva Gil-Iturbe, Ming Zhou, Matthias Quick. Insight into the mechanism of H+-coupled nucleobase transport. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 33. e2302799120
Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, et al. Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase. Nature Communications. 2023. 14. 1. 2174-2174

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MISC (18)：

永森收志, 森山理美, パッタマ・ウィリヤサムクン. ヒト栄養素トランスポーターと分子標的創薬研究糖やアミノ酸の取り込み装置を制御して病気を治す. 化学と生物. 2020. 58. 9. 520-528
永森收志, 河本泰治, Wiriyasermkul Pattama, 中込咲綾, 金井好克. 疾患起因性変異ノックインマウスを用いた日本人型シスチン尿症変異の特性解析. 日本尿路結石症学会誌. 2015. 14. 2. 151-153
Hayato Ikeda, Tadashi Watabe, Shushi Nagamori, Yoko Tanaka, Pattama Wiriyasermkul, Yasukazu Kanai, Sadahiro Naka, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa. Evaluation of the amino acid transporter: comparison study between FBPA and BPA in vitro. JOURNAL OF NUCLEAR MEDICINE. 2015. 56. 3
Printip Wongthai, Kohei Hagiwara, Yurika Miyoshi, Pattama Wiriyasermkul, Pornparn Kongpracha, Noriyoshi Isozumi, Ryuichi Ohgaki, Kenjiro Tadagaki, Kenji Hamase, Shushi Nagamori, et al. Mechanisms of tumor cell uptake of 4-borono-phenylalanine, a B-10 carrier of boron neutron capture therapy, mediated by system L amino acid transporters. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 97P-97P
Shushi Nagamori, Pattama Wiriyasermkul, Noriyoshi Isozumi, Pornparn Kongpracha, Ryuichi Ohgaki, Yoshikatsu Kanai. Evaluation of amino acid transporter LAT1 as a molecular target of anti-tumor therapy by means of the combination of comprehensive proteomics and transport assay. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 130P-130P

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Education (2)：

2008 - 2011 Osaka University Department of Pharmacology, Graduate School of Medicine Research student
2007 - 2011 Kyorin University Graduate School of Medicine Ph.D (Medical Science: Molecular Pharmacology)

Professional career (1)：

博士(医学) (杏林大学)

Work history (9)：

2023/09 - 現在 Iwate University Department of Biological Chemistry and Food Science, Faculty of Agriculture Associate Professor
2023/09 - 現在 Jikei University Center for SI Medical Research Visiting Researcher
2023/04 - 2023/08 Jikei University Center for SI Medical Research Lecturer
2023/04 - 2023/08 Jikei University Department of Laboratory Medicine Lecturer
2020/10 - 2023/03 Jikei University Department of Laboratory Medicine Special Appointed Assistant Professor

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