Research field (3)：
Neurology
, Genomics
, Medical biochemistry
Research keywords (3)：
ヒトゲノム
, 神経変性疾患
, パーキンソン病
Research theme for competitive and other funds (5)：
2021 - 2024 パーキンソン病関連遺伝子の網羅的解析による遺伝的リスク因子の解明
2016 - 2019 Mutational analysis of the CHCHD2 gene in neurodegenerative diseases
2013 - 2017 The detection of modifier gens in alpha-synuclein multiplications
2013 - 2016 Search for the causative gene in consanguineous families with Parkinson's disease
2011 - 2012 Autozygosity mapping in consanguineous families with Parkinson's disease
Papers (90)：
Mayu Ishiguro, Manabu Funayama, Taku Hatano, Hiroshi Nishida, Yuko Wada, Kazuyuki Noda, Masahiko Tomiyama, Hiroyo Yoshino, Yuanzhe Li, Stephanie Ong, et al. Genetic and clinical study of PARK7 in Japanese Parkinson's disease. Heliyon. 2024. 10. 15. e35271
Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita, et al. CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis. PNAS Nexus. 2024. 3. 8
Toshiki Tezuka, Mayu Ishiguro, Daisuke Taniguchi, Ehoto Osogaguchi, Kahori Shiba-Fukushima, Jun Ogata, Ryota Ishii, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, et al. Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson's disease. Neurobiology of disease. 2024. 199. 106571-106571
Kazuo Yamashiro, Kaito Takabayashi, Koji Kamagata, Yuichiro Nishimoto, Yuka Togashi, Yohsuke Yamauchi, Kotaro Ogaki, Yuanzhe Li, Taku Hatano, Yumiko Motoi, et al. Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment. Neurobiology of Disease. 2024. 193. 106464-106464
Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-Ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, et al. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nature medicine. 2023. 29. 6. 1448-1455
N. Hattori, K. Nishioka, T. Matsushima, Y. Li, H. Yoshino, M. Takanashi, M. Funayama. Clinicogenetic study of CHCHD2 in patients with autosomal dominant familial Parkinson's disease. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2015. 357. E58-E59
H. Tomiyama, M. Ando, Y. Li, H. Yoshino, N. Hattori. Mutation analysis for DNAJC6 in patients with early-onset Parkinson's disease. MOVEMENT DISORDERS. 2013. 28. S400-S401
H. Tomiyama, H. Yoshino, K. Ogaki, L. Li, C. Yamashita, Y. Li, M. Funayama, R. Sasaki, Y. Kokubo, S. Kuzuhara, et al. Mutation analysis for PLA2G6 in patients with Parkinson's disease/frontotemporal type of dementia. MOVEMENT DISORDERS. 2012. 27. S470-S471
