Hattori Koichi

Affiliation and department：
Job title：特任先任准教授
Research theme for competitive and other funds (33)：

2022 - 2025 Feed-forward regulatory regulation driven by tumor specific endothelial cells in pathophysiology of leukemia
2021 - 2024 血管内皮障害による炎症性腸疾患の病態制御機構の解明
2021 - 2024 The Role of Fibrinolytic and Coagulation Factors, a Subset of Angiocrine Factors in Cytokine Storm-Associated Diseases
2019 - 2022 Roles of angiocrine system in the process of engraftment after hematopoietic stem cell transplantation
2019 - 2022 Role of the angiocrine factor Egfl7 in multiple myeloma progression and drug resistance

2018 - 2022 Roles of angiocrine factors in the pathophysiological regulation systems of inflammatory bowel diseases

2017 - 2020 Roles of vascular niche in pathophysiology of leukemia and lynphoma

2016 - 2019 Roles of bone marrow specific endothelial cells in the process of engraftment after hematopoietic stem cell transplantation

2016 - 2019 Fibrinolytic factors control MSC expansion thereby enhancing hematopoiesis

2016 - 2019 Design of the active site-directed plasmin inhibitor oriented to the clinical applications

2015 - 2018 Development of new therapy of inflammatory diseases in parenchymal organs by fibrinolytic pathway

2014 - 2017 Roles of angiocrine factor signaling in the pathogenesis of leukemia/lymphoma

2013 - 2016 Studies in the action mechanism of fibrinolytic system on the inflammatory bowel disease and its clinical applications

2011 - 2016 A novel treatment strategy for inflammatory lung diseases, using de-differentiation mechanisms toward bronchiolar stem cells

2013 - 2015 Plasmin inhibition protects against severe acute inflammation in solid organs.

2012 - 2015 Blocking fibrinolytic system in mice reduces colorectal carcinogenesis associated with chronic colitis.

2010 - 2015 Functional analysis of the fibrinolytic system in bone marrow-derived cell mediated tumor angiogenesis and growth

2011 - 2013 The coagulation and the fibrinolytic system are essential drivers in the pathogenesis of leukemia and lymphoma

2011 - 2012 生殖系列分化と初期胚発生過程におけるプロテアーゼ活性の機能解析

2011 - 2012 Plasmin inhibition protects against dextran sulfate sodium-induced colitis

2010 - 2011 血液凝固系とToll様受容体による自然炎症の分子基盤と病態形成

2010 - 2011 血液線維素溶解系による免疫制御機構の解明とその臨床応用

2010 - 2011 骨格筋細胞の分化増殖過程における細胞周期制御機構

2009 - 2011 Functional differences between malignant niche on the process of leukemia/lymphoma progression and hematopoietic stem cell niche on the process of cord blood graft engraftment

2008 - 2010 The role of megakaryocytic lineage cells in leukemia/lymphoma cell proliferation

2008 - 2009 虚血ニッチの形成過程とその生理学的意義の解明

2008 - 2009 線溶系因子を標的としたがん治療法の開発

2006 - 2007 虚血ニッチの形成過程とその生理学的意義の解明

2006 - 2007 線溶系因子を標的としたがん治療法の開発

2005 - 2006 幹細胞の未分化性と骨髄内微小環境との相互作用

2005 - 2005 線溶系因子を標的としたがん治療法の開発

2003 - 2004 Platelets support tumor growth by promoting angiogenesis (Searching for the angiogenic switch)

進行中の研究課題・終了した研究課題

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Papers (114)：

Salama Y, Munakata S, Osada T, Takahashi S, Hattori K, Heissig B. Heparin-binding EGF-Like Growth Factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers. Cell Death Dis. 2024. 15. 753
YatsenkoT, Rios R, Rios T, Salama Y, Takahashi S, Adachi E, Tabe Y, Hattori N, Osada T, Naito T, et al. The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction. Frontier Immunol. 2024. 15. 1445294
Maksym Skrypnyk, Tetiana Yatsenko, Oleksandra Riabets, Yousef Salama, Margarita Skikevych, Taro Osada, Morikuni Tobita, Satoshi Takahashi, Koichi Hattori, Beate Heissig. Interleukin-10 induces TNF-driven apoptosis and ROS production in salivary gland cancer cells. Heliyon. 2024. 10. 11. e31777-e31777
Mizoue Y, Ikeda T, Ikegami T, Riabets O, Oishi Y, Tobita M, Akutsu H, Hattori K, Heissig B, Koide H. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells. Int J Dev Biol. 2024
Yatsenko T, Rios R, Rios T, Salama Y, Takahashi S, Tabe Y, Naito T, Takahashi T, Hattori K, Heissig B. Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19. Frontier Immunol. 2024. 14

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MISC (150)：

服部浩一, 高橋聡, 長田太郎, ハイジッヒ・ベアテ. 炎症性疾患病態における血管ニッチの機能解明. 炎症と免疫. 2021. 29. 2. 178-183
服部浩一, 高橋聡, 長田太郎, Heissig Beate. 線溶系と炎症性疾患. 日本血栓止血学会雑誌. 2020
長田太郎野村収服部浩一. 腸管外合併症に対するGMAの有効性. 日本アフェレーシス学会雑誌. 2020
服部浩一, 高橋聡, ハイジ・ベアテ. アンジオクラインシステムによるマクロファージ系細胞動態を通じた組織再生・修復制御機構(Angiocrine system regulates macrophage-dependent aberrant tissue repair and remodeling). 臨床血液. 2018. 59. 9. 1538-1538
服部浩一. 【生体の"形"と血小板/凝固線溶システム】炎症性腸疾患と血液線維素溶解系. 日本血栓止血学会誌. 2017. 28. 5. 618-622

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Patents (4)：

COVID-19の重症化を予測する血中バイオマーカー
炎症性疾患治療剤
組織プラスミノーゲン活性化因子を使用した末梢血幹細胞動員及び組織再生促進
血管新生方法及び血管新生剤

Books (1)：

動物/疾患モデルの作製技術・病態解析・評価手法
技術情報協会 2017 ISBN:9784861046650

Education (2)：

1998 - Juntendo University Faculty of Medicine
1991 - Juntendo University Faculty of Medicine

Professional career (1)：

医学博士 (順天堂大学)

Work history (9)：

2014/04 - 現在 Juntendo University Graduate School of Medicine
2007/04 - The University of Tokyo
2004/04 - The University of Tokyo
2003/04 - Juntendo University Faculty of Medicine
2002/09 - Juntendo University Faculty of Medicine

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Committee career (5)：

2019/03 - 現在日本再生医療学会評議員
2007/10 - 現在日本血液学会代議員
2016 - 2018 日本学術振興会科学研究費助成事業審査委員
2009 - 文部科学省がん特定領域研究国際学術研究交流委員
2007 - 文部科学省がん特定領域研究国際学術研究交流委員

Awards (4)：

2009 - 日本白血病研究基金一般研究賞
2003 - 順天堂大学医学部学術奨励賞
2002 - 米国血液学会 Travel Award
1991 - 順天堂大学医学部同窓会賞

Association Membership(s) (9)：

日本血液疾患免疫療法学会 , The International Society for Stem Cell Research , the American Association for Cancer Research , the American Society of Hematology , THE JAPANESE SOCIETY OF INFLAMMATION AND REGENERATION , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , THE JAPANESE SOCIETY OF HEMATOLOGY

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