Sei Yonezawa

ヨネザワセイ | Sei Yonezawa

Affiliation and department：
Job title：講師

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (6)：核内受容体 , 腎疾患 , Cancer , Lipid metabolism , Diabetes , DDS

Research theme for competitive and other funds (5)：

2022 - 2025 抗原提示細胞を標的としたmRNA/LNP製剤の開発と個別化がん免疫療法への応用
2021 - 2025 電荷反転型LNP製剤の精密設計と核酸・ペプチド医薬品開発への応用
2019 - 2020 尿細管間質領域特異的な薬物送達による脂質代謝調節に基づいた新規腎疾患治療戦略の確立
2013 - 2015 Construction of novel liposome with directional quality to kidney tubule and tubulointerstitial region to control the development of diabetic nephropathy
2011 - 2012 Basis examination aimed at establishing a novel therapeutics that target the accumulated lipid in diseased kidney

Papers (28)：

Sei Yonezawa, Yasushi Kawasaki, Yasuhiro Natori, Akinori Sugiyama. Improvement of LXR-mediated lipid metabolism in nephrotic model kidney accompanied by suppression of inflammation and fibrosis. Biochemical and Biophysical Research Communications. 2023. 666. 122-127
Masahiro Hashimoto, Sei Yonezawa, Song Furan, Chiori Nitta, Noriyuki Maeda, Koji Tomita, Ayano Yokouchi, Hiroyuki Koide, Tomohiro Asai. Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid. Biomaterials science. 2023. 11. 9. 3269-3277
Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Beverly Chou, Yu Hoshino, Sei Yonezawa, Naoto Oku, Tomohiro Asai, Kenneth J Shea. Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023. 355. 745-759
Hiroyuki Koide, Hiroki Ochiai, Hikaru Suzuki, Shinya Hirata, Midori Watanabe, Sei Yonezawa, Takehisa Dewa, Naoto Oku, Tomohiro Asai. Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome-protein complex. Journal of materials chemistry. B. 2022. 10. 35. 6768-6776
Hiroyuki Koide, Satoshi Hirano, Takafumi Ide, Kazuhiro Saito, Hikaru Suzuki, Go Yasuno, Yoshitaka Hamashima, Sei Yonezawa, Naoto Oku, Tomohiro Asai. Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide. ADVANCED FUNCTIONAL MATERIALS. 2021. 31. 3

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MISC (65)：

宮嵜拓海, 米澤正, 室谷千佳, 浅井知浩. 腎疾患に対するリポソーム製剤の有用性. 第31回DDSカンファランス. 2023
又吉克樹,髙橋沙也加, 龍聡平,米澤正, 尾﨑奈穂子,田中陽平,浅井知浩. pH応答性ジペプチド脂質を含有するmRNA/LNP製剤の開発. 日本核酸医薬学会. 2023
渡邊翠, 小出裕之, 平田真也, 米澤正, 出羽毅久, 奥直人, 奥直人, 浅井知浩. Development of protein delivery strategy using multi-functionalized liposomes. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
米澤正,浅井知浩. 腎への薬物送達と腎疾患治療を目指して. 第30回DDSカンファランス. 2022
小出裕之, 米澤正, 出羽毅久, 奥直人, 浅井知浩. 社会のアンメットニーズに応えるDDS 凍結融解技術を駆使した核酸・タンパク質送達方法の開発. 日本DDS学会学術集会プログラム予稿集. 2022. 38回. 74-74

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Books (2)：

Angiogenesis assays : a critical appraisal of current techniques
J. Wiley & Sons 2006 ISBN:9780470016008
ナノDDS製剤研究におけるバイオイメージング

Education (3)：

2004 - 2007 University of Shizuoka Graduate School of Pharmaceutical Sciences
2002 - 2004 University of Shizuoka Graduate School of Pharmaceutical Sciences
1998 - 2002 University of Shizuoka School of Pharmaceutical Sciences Division of Medicinal Science

Professional career (1)：

博士(薬学) (静岡県立大学)

Work history (4)：

2019/01 - 現在 University of Shizuoka School of Pharmaceutical Sciences
2009/04 - 2018/12 Iwate Medical University School of Pharmacy Assistant Professor
2008/04 - 2009/03 Iwate Medical University School of Pharmacy
2007/04 - 2008/03 National Center for Global Health and Medicine

Awards (1)：

2003/07 - Controlled Release Society Travel Award Intracellular distribution dynamics of cationic lipid-mediated double-stranded RNA in cells by using confocal laser scan microscopy.

Association Membership(s) (4)：

日本腎臓学会 , 日本薬剤学会 , 日本脂質生化学会 , 日本薬学会

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