Rchr
J-GLOBAL ID：201801008003211184
Update date: Jul. 25, 2024
Okumura Kazuhiro
オクムラ カズヒロ | Okumura Kazuhiro
Affiliation and department：
Research field (4)：
Zoological sciences
, Genetics
, Tumor biology
, Laboratory animal science
Research keywords (5)：
がん微小環境
, 遺伝学
, 疾患モデルマウス
, 発がん
, 野生由来近交系マウス
Research theme for competitive and other funds (13)：
- 2023 - 2026 遺伝学的スクリーニングによるPAK1阻害の効果を増強する因子の探索
- 2022 - 2025 神経幹細胞による大脳発生と脳腫瘍発症機構の解明
- 2022 - 2025 表皮および樹状細胞間のがん微小環境におけるクロストーク解析
- 2019 - 2022 発がん感受性に寄与する表皮細胞とランゲルハンス細胞間の相互作用解析
- 2016 - 2020 Development of highly sensitive genotyping method by blood circulating tumor DNA enrichment using PIP polyamide
- 2015 - 2018 Identification of cancer-related gene polymorphisms by genetic integration of mouse and human
- 2016 - 2017 腫瘍悪性化機構におけるMeis1下流因子の網羅的解析
- 2013 - 2015 Identification of resistance genes in the process of tumor progression
- 2011 - 2013 Meis1 regulates epidermal stem cells and is required for skin tumorigenesis
- 2011 - 2012 The elucidation of carcinogenic mechanism by two-stage skin carcinogenesis in CENP-R null mice
- 2010 - 2011 Meis1遺伝子の皮膚幹細胞における機能解析
- 2009 - 2011 Monitoring of social behavior associated with onset of hearing loss used model mice
- 2008 - 2010 Establishment and characterization of mouse models for hearing loss based on Molecular interaction
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Papers (29)：
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Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Yoshinori Hasegawa, et al. Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model. Cancer science. 2024
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Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Kimi Araki, et al. Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis. The Journal of investigative dermatology. 2024
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Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi. Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation. The Journal of investigative dermatology. 2022. 142. 9. 2323-2333
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Eriko Isogai, Kazuhiro Okumura, Megumi Saito, Yurika Tokunaga, Yuichi Wakabayashi. Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum. Biomedical research (Tokyo, Japan). 2022. 43. 3. 91-97
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Kazuhiro Okumura, Megumi Saito, Yuichi Wakabayashi. A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes. Experimental animals. 2021. 70. 3. 272-283
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MISC (78)：
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奥村和弘, 盛永敬郎, 田中青空, 音山敬祐, 徳永夕莉香, 斎藤慈, 荒木喜美, 若林雄一. Deletion of Pak1 enhances anti-tumor immunity by the activation of dendritic cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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若林雄一, 奥村和弘, 斎藤慈, 徳永夕莉香, 音山敬祐, 田中青空. Identification of STMM loci controlling DMBA/TPA-induced skin tumors. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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奥村和弘, 齋藤慈, 徳永夕莉香, 磯貝恵理子, 荒木喜美, 若林雄一. Pak1-3’UTRの機能的多型は選択的ポリアデニル化を介して皮膚腫瘍感受性を制御する. 日本実験動物学会総会講演要旨集(Web). 2022. 69th
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奥村和弘, 齋藤慈, 磯貝恵理子, 荒木喜美, 若林雄一. Pak1の3’UTR多型は代替ポリアデニル化を制御しマウス皮膚がん感受性に影響を与える. 日本癌学会学術総会抄録集(Web). 2021. 80th
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奥村和弘. 多段階皮膚発がんマウスモデルを用いたがん修飾因子の同定. 日本実験動物学会総会講演要旨集(Web). 2021. 68th
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Professional career (1)：
Committee career (1)：
- 2022/04 - 現在 日本実験動物学会 学術集会委員
Awards (5)：
- 2020 - JALAS Incentive award Identification of tumour modifier genes using a multistage skin carcinogenesis mouse model
- 2018 - モロシヌス研究会 森脇和郎賞
- 2015 - 第29回国際哺乳類ゲノム会議 Outstanding research poster賞
- 2013 - 第27回国際哺乳類ゲノム会議 Outstanding research poster賞
- 2009 - 第23回国際哺乳類ゲノム会議 Outstanding research poster賞
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