Sakai Yasuhiro

• Fujita Health University School of Medicine  Department of Joint Research Laboratory of Clinical Medicine   Visiting Associate Professor

• 2023 - 2025 Development of a novel companion diagnostic system for PARP inhibitors
• 2022 - 2025 Centrosome duplication-related molecule SAC3D1: A model of breast cancer progression and prognostic markers (22K06987)
• 2021 - 2024 Development of chick embryo chorioallantoic membrane assay using oral carcinoma cell lines with high metastatic potential to identify therapeutic target molecules (21K09862)
• 2022 - 2023 Breast cancer progression and prognosis associated with centrosome duplication-related molecule SAC3D1
• 2020 - 2023 A novel strategy by PARP inhibitors for sporadic breast cancers (20K07686)
2021 - 2022 Molecular biological analysis of ganp, a susceptibility gene for human testicular germ cell tumors-Molecular basis of teratomagenesis-
2020 - 2022 New mechanism of teratoma formation associated with GANP function (20K16228)
2020 - 2021 Development of AI to help pathological diagnosis, and assimilation and construction of "AI medical image" knowledge (JP20lk1010027)
2019 - 2020 Development of AI to help pathological diagnosis, and assimilation and construction of "AI medical image" knowledge (JP19lk1010040)
2019 - 2020 Pathological and molecular biological analysis for the mechanism of increased anticancer drug sensitivity by DSS1 dysfunction
2016 - 2018 Development of glycobiological markers specific for normal mesothelium and mesothelioma (16K19078)
2012 - 2013 Difference in glycostructure of podoplanin among cellular species, and the methods of distinguishing pleural mesothelioma and lung carcinoma.

• Kouhei Sakurai, Seiji Yamada, Rika Ito, Mako Ochiai, Tatsuya Ando, Yasuhiro Sakai, Taku Kato, Hiroyasu Ito. Chromogenic in situ hybridization reveals specific expression pattern of long non-coding RNA DRAIC in formalin-fixed paraffin-embedded specimen. Non-coding RNA Research. 2024. 9. 1. 76-83
• Yasuhiro Sakai, Kazuhiko Kuwahara. Carcinogenesis caused by transcription-coupled DNA damage through GANP and other components of the TREX-2 complex. Pathology International. 2024. in press
• Mai Iwaya, Yuichiro Hayashi, Yasuhiro Sakai, Akihiko Yoshizawa, Yugo Iwaya, Takeshi Uehara, Masanobu Kitagawa, Masashi Fukayama, Kensaku Mori, Hiroyoshi Ota. Artificial intelligence for evaluating the risk of gastric cancer: reliable detection and scoring of intestinal metaplasia with deep learning algorithms. Gastrointestinal Endoscopy. 2023. 98. 6. 925-933
• Taku Kato, Kyojiro Kawakami, Kosuke Mizutani, Tatsuya Ando, Yasuhiro Sakai, Kouhei Sakurai, Shohei Toyota, Hidetoshi Ehara, Hiroyasu Ito, Masafumi Ito. H19 in serum extracellular vesicles reflects resistance to AR axis-targeted therapy among CRPC patients. Cancer Genomics & Proteomics. 2023. 20. 5. 456-468
• Yasuhiro Sakai, Kazuya Yoshinaga, Ayaka Yoshida, Andri Rezano, Kazuya Shiogama, Yoshiaki Kawashima, Tadashi Yoshizawa, Akihiko Yoshizawa, Shingo Hatakeyama, Chikara Ohyama, et al. Testicular teratomagenesis from primordial germ cells with overexpression of germinal center-associated nuclear protein. Cancer Science. 2023. 114. 4. 1729-1739

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• Quick Reference Guide on Diagnostic Pathology [Pathology and Clinical Medicine, 2023 Extra Edition]
  Bunkodo Co. 2023
• Pathological Knowledge You Should Know [Otorhinolaryngology, 2022 Vol.1, No.5]
  Kagakuhyoronsha Co. 2022
• Artificial Intelligence and Digital Pathology [Pathology and Clinical Medicine, 2021 Vol.39, No.8]
  Bunkodo Co. 2021
• GANP: An immunoactive protein with a key role in tumourigenesis
  Scientia 2020
• Developing AI and designing ICT infrastructure for surgical pathologists by JP-AID project
  Igaku-Shoin 2020

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• Workshop III: The work and responsibilities of the pathologist 〜Legal issues of utilizing pathology AI〜
  (The 53rd Annual Meeting of the Japanese Association of Medical Law 2023)
• Analysis of chemosensitivity based on DSS1 and PCID2 expression in breast cancers
  (The 63rd Annual Meeting of the Japanese Society of Clinical Chemistry 2023)
• Immunohistochemical analysis of ganp, a susceptibility gene for human testicular germ cell tumors to reveal molecular basis of teratomagenesis
  (The 64th Annual Meeting of Japanese Histochemistry and Cytochemistry 2023)
• Spermidine enhances the efficacy of adjuvant in HBV vaccination
  (The 31st Annual Meeting of the Japanese Association for Antiviral Therapy 2023)
• Analysis of the molecular mechanisms regulating anchorageindependent cancer cell cluster formation
  (The 112th Annual Meeting of the Japanese Society of Pathology 2023)

ｍore...

• 2011 - 2014 Shinshu University Graduate School of Medicine Institute of Organ Transplants, Reconstructive Medicine and Tissue Eginieering
• 2003 - 2009 Shinshu University School of Medicine
• 2000 - 2003 Tokai High School

• M.D.
• Ph.D. in Medical Science (Shinshu University Graduate School of Medicine)
• F.I.A.C. (International Academy of Cytology)

• 2024/01 - 現在 Hamamatsu University School of Medicine Department of Tumor Pathology Associate Professor
• 2024/01 - 現在 Fujita Health University School of Medicine Department of Joint Research Laboratory of Clinical Medicine Visiting Associate Professor
• 2021/05 - 2023/12 Fujita Health University School of Medicine Department of Joint Research Laboratory of Clinical Medicine Senior Assistant Professor
• 2018/04 - 2021/04 Fujita Health University School of Medicine Department of Diagnostic Pathology Senior Assistant Professor
• 2015/04 - 2018/03 Faculty of Medical Sciences, University of Fukui Department of Tumor Pathology Assistant Professor
2014/04 - 2015/03 University of Fukui Hospital Division of Surgical Pathology Resident Pathologist
2010/04 - 2011/03 Shinshu University Hospital Clinical Resident
2009/04 - 2010/03 Japanese Red Cross Society Suwa Hospital Clinical Resident

• 2024/01 - 現在 Japanese Society of Laboratory Medicine Councilor
• 2022/04 - 現在 The Japanese Society of Pathology Editorial board of the Japanese Journal of Diagnostic Pathology
• 2021/11 - 現在 The Japanese Society of Pathology Working group regarding the JP-AID Database project
• 2021/06 - 現在 Japanese Society for Clinical Cytology Social insurance committee
• 2021/06 - 現在 Japanese Society for Clinical Cytology Councilor
2021/04 - 現在 三重大学臨床検査専門研修プログラム プログラム管理委員会委員
2019/05 - 現在 The Japanese Society of Pathology Working group regarding the formulation of the AI (artificial intelligence) guideline
2019/04 - 現在 The Japanese Society of Pathology Academic Councilor
2021/08 - 2022/04 The Japanese Society of Pathology Working group supporting the JP-AID commercialization of artificial intelligence
2020/04 - 2022/04 The Japanese Society of Pathology Gender equality and work style reforms committee
2018/08 - 2021/07 The Japanese Society of Pathology Japan Pathology AI Diagnostics (JP-AID) project staff

• 2023/04 - The Japanese Society of Pathology Incitement Award
• 2014/11 - The Japanese Society of Clinical Cytology Poster Award (The 53rd Annual Autumn Meeting)
• 2014/04 - The Japanese Society of Pathology The Japanese Society of Pathology’s Centennial Anniversary Award for Young Scientists in 2013
• 2013/08 - The Japanese Society of Pathology Best Poster Award (The 10th Japanese Society of Pathology Conference for Young Scientists)
• 2012/11 - Society for Glycobiology Travel Award (2012 Annual Conference)
2008/05 - The Japanese Society of Pathology Highest Award in Student Poster (The 97th Annual Meeting)

Japanese Dermatological Association ,  Japan Society of Histochemistry and Cytochemistry ,  Japan Society of Clinical Chemistry ,  Japanese Skin Cancer Society ,  Japan Dermatohistopathology Society ,  Japanese Association of Clinical Laboratory Physicians ,  Japanese Society of Laboratory Medicine ,  The International Academy of Pathology, Japanese Division ,  The International Academy of Cytology ,  The Japanese Society of Clinical Cytology ,  The Japanese Society of Pathology