Takayuki Isagawa

Affiliation and department：
Other affiliations (1)：

Jichi Medical University

Research theme for competitive and other funds (11)：

2022 - 2025 低酸素シグナルに着目した心臓病治療法の開発
2022 - 2025 NADHを標的とした新たな心臓線維化治療法の開発
2020 - 2024 担がん状態が心機能および血圧に及ぼす影響の解析
2019 - 2022 心臓リモデリングにおける抗線維化マクロファージの機能解析
2017 - 2020 循環器疾患における時計遺伝子Clif/Bmal2の役割の解明

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Papers (58)：

Hiroki Sekine, Haruna Takeda, Norihiko Takeda, Akihiro Kishino, Hayato Anzawa, Takayuki Isagawa, Nao Ohta, Shohei Murakami, Hideya Iwaki, Nobufumi Kato, et al. PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nature metabolism. 2024
Aya Shiba-Ishii, Takayuki Isagawa, Toshihiro Shiozawa, Naoko Mato, Tomoki Nakagawa, Yurika Takada, Kanon Hirai, Jeongmin Hong, Anri Saitoh, Norihiko Takeda, et al. Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2024. 167249-167249
Michal Sobecki, Jing Chen, Ewelina Krzywinska, Shunmugam Nagarajan, Zheng Fan, Eric Nelius, Josep M Monné Rodriguez, Frauke Seehusen, Amro Hussein, Greta Moschini, et al. Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell stem cell. 2022. 29. 10. 1459-1474
Riho Kurata, Masamitsu Harada, Jun Nagai, Xiaofeng Cui, Takayuki Isagawa, Hiroaki Semba, Yasuhiro Yoshida, Norihiko Takeda, Koji Maemura, Tomo Yonezawa. Nucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm. Journal of visualized experiments : JoVE. 2022. 185
Kuniyo Sueyoshi, Daisuke Komura, Hiroto Katoh, Asami Yamamoto, Takumi Onoyama, Tsuyoshi Chijiwa, Takayuki Isagawa, Mariko Tanaka, Hiroshi Suemizu, Masato Nakamura, et al. Multi-tumor analysis of cancer-stroma interactomes of patient-derived xenografts unveils the unique homeostatic process in renal cell carcinomas. ISCIENCE. 2021. 24. 11

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MISC (81)：

砂河孝行, 砂河孝行, 森岡勝樹, 杉本大樹, 佐藤滋, 口丸高弘, ARIUNBOLD Chuluun-Erdene, 佐藤達之, 大野和寿, 澤城大悟, et al. Comprehensive analysis of HIF-1α target genes in macrophage adaptation for inflammation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
砂河孝行, 砂河孝行, 澤城大悟, 佐藤達之, 口丸高広, 杉本大樹, 佐藤滋, CHULUUN-ERDENE Ariunbold, 大野和寿, 興梠貴英, et al. 低酸素よるミトコンドリアNADHの蓄積は線維芽細胞におけるコラーゲン合成を促進する. 日本生化学会大会(Web). 2023. 96th
倉田里穂, 原田将光, 砂河孝行, 仙波宏章, 武田憲彦, 前村浩二, 米澤朋. Establishment of novel high-standard chemiluminescent assay for protozoan NTPase and Its High-Throughput Screening. 月刊Precision Medicine. 2021. 4. 8
熊谷飛鳥, 熊谷飛鳥, 倉田里穂, 尾崎惠一, 砂河孝行, 仙波宏章, 武田憲彦, 前村浩二, 米澤朋. ヒトγδT細胞抗腫瘍活性を用いた新規免疫細胞治療のための創薬研究. Bio Clinica. 2019. 34. 9. 959-963
内田真人, 河野浩章, 砂河孝行, 山方勇樹, 米倉剛, 江口正倫, 吉牟田剛, 南貴子, 古賀聖士, 恒任章, et al. 透析高血圧症の原因として虚血性心疾患が考えられた1例. 日本高血圧学会臨床高血圧フォーラムプログラム・抄録集. 2019. 8回. 201-201

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Patents (1)：

固形癌の再発予測のための試験方法および再発予防剤

Professional career (1)：

博士(理学)

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