Rchr
J-GLOBAL ID：201801008313377635   Update date: Sep. 03, 2024

ATSUSHI HOSHINO

ホシノ アツシ | ATSUSHI HOSHINO
Affiliation and department：
Kyoto Prefectural University of Medicine

About Kyoto Prefectural University of Medicine


Research field  (1)： Cardiology
Research keywords  (5)： Bioengineering ,  Gene therapy ,  Screening ,  autophagy ,  mitochondrial biology
Research theme for competitive and other funds  (18)：
  • 2024 - 2030 認知症保護的バリアントの機能解明に基づく治療の研究開発
  • 2023 - 2028 難治性肝疾患に対する画期的な小児ゲノム編集治療の創出
  • 2024 - 2027 疾患アリル特異的ゲノム編集による網膜色素変性症治療
  • 2024 - 2026 Development of an AAV-deliverable compact and enhanced base editor
  • 2022 - 2025 線維化セクレトームの転写制御ネットワーク解明と心不全治療応用
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Papers (37)：
  • Tomohiro Hino, Satoshi N Omura, Ryoya Nakagawa, Tomoki Togashi, Satoru N Takeda, Takafumi Hiramoto, Satoshi Tasaka, Hisato Hirano, Takeshi Tokuyama, Hideki Uosaki, et al. An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis. Cell. 2023. 186. 22. 4920-4935
  • Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma, et al. An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models. Science translational medicine. 2023. 15. 711. eadi2623
  • Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Shunsuke Kita, Yusuke Higuchi, Yuhei Kirita, Ryutaro Kotaki, Keisuke Tonouchi, et al. Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Nature communications. 2023. 14. 1. 4198-4198
  • Yoshito Minami, Atsushi Hoshino, Yusuke Higuchi, Masahide Hamaguchi, Yusaku Kaneko, Yuhei Kirita, Shunta Taminishi, Toshiyuki Nishiji, Akiyuki Taruno, Michiaki Fukui, et al. Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nature communications. 2023. 14. 1. 4084-4084
  • Brandon Havranek, Graeme Walker Lindsey, Yusuke Higuchi, Yumi Itoh, Tatsuya Suzuki, Toru Okamoto, Atsushi Hoshino, Erik Procko, Shahidul M. Islam. A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo. Communications Biology. 2023. 6. 1
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MISC (22)：
  • Makoto Ariyoshi, Atsushi Hoshino, Yoshifumi Okawa, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Satoaki Matoba. Age Related Cardiac Dysfunction and Pancreatic beta-cell Function in Diabetes Were Improved by P53 Inhibition Through Parkin-mediated Mitophagy. CIRCULATION. 2016. 134
  • Makoto Ariyoshi, Atsushi Hoshino, Yoshifumi Okawa, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Satoaki Matoba. Age Related Cardiac Dysfunction and Pancreatic beta-cell Function in Diabetes Were Improved by P53 Inhibition Through Parkin-mediated Mitophagy. CIRCULATION. 2016. 134
  • Satoshi Kaimoto, Atsushi Hoshino, Makoto Ariyoshi, Yoshifumi Okawa, Motoki Uchihashi, Kuniyoshi Fukai, Kazunori Ono, Shuhei Tateishi, Eri Iwai-Kanai, Satoaki Matoba. Activation of PPAR alpha During the Progressive Phase of Heart Failure Improved Myocardial Energetics and Function in Pressure Overload Heart Failure. CIRCULATION. 2014. 130
  • Satoshi Kaimoto, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Kuniyoshi Fukai, Motoki Uchihashi, Kazunori Ono, Shuhei Tateishi, Eri Iwai-Kanai, Satoaki Matoba. Activation of PPAR Alpha during Heart Failure Maintained Myocardial Function and Energetics in Mice Transverse Aortic Constriction (TAC) Model. JOURNAL OF CARDIAC FAILURE. 2014. 20. 10. S189-S189
  • Motoki Uchihashi, Atsushi Hoshino, Makoto Ariyoshi, Shuhei Tateishi, Kazunori Ono, Satoshi Kaimoto, Kuniyoshi Fukai, Eri Kanai, Satoaki Matoba. Ketone Body Metabolism Attenuates Oxidative Stress and Cardiac Remodeling in Pressure Overload Heart Failure. JOURNAL OF CARDIAC FAILURE. 2014. 20. 10. S204-S204
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Books (4)：
  • ミトコンドリアダイナミクス : 機能研究から疾患・老化まで
    エヌ・ティー・エス 2021 ISBN:9784860437466
  • 創薬研究者がこれだけは知っておきたい最新のウイルス学
    技術情報協会 2021 ISBN:9784861048555
  • 新しい臨床を開拓するための分子循環器病学
    南山堂 2019 ISBN:9784525249410
  • Aging-related changes in mitochondrial function and implication for heart failure therapy. Aging and Heart Failure: Mechanisms & Management edited by Bodh I. Jugdutt
    2014
Lectures and oral presentations  (22)：
  • 疾患保護多型ゲノム編集治療とツール開発
    (第30回日本遺伝子細胞治療学会 2024)
  • Defects in Mitophagy Drive the Pathophysiology of ANT1-associated Myopathy.
    (第87回日本循環器学会総会 2023)
  • Liver lipophagy activates lysosomal exocytosis and ameliorates Non-alcoholic steatohepatitis.
    (第87回日本循環器学会総会 2023)
  • 18. 線維化セクレトーム制御転写ネットワークの解明
    (第70 回日本心臓病学会学術集会 2022)
  • オートファジーによるミトコンドリア品質管理と創薬応用
    (第31回日本循環薬理学会 2021)
ｍore...
Education (2)：
  • 2007 - 2011 Kyoto Prefectural University of Medicine
  • 1997 - 2003 Kyoto Prefectural University of Medicine
Professional career (1)：
  • 医学博士 (京都府立医科大学)
Work history (10)：
  • 2022/04 - 現在 京都府立医科大学 循環器内科 講師
  • 2019/07 - 2022/03 Kyoto Prefectural University of Medicine
  • 2017/09 - 2019/06 Kyoto Prefectural University of Medicine Cardiovasular medicine Assistant professor
  • 2015/08 - 2017/07 Japan Society for the Promotion of Science Postdoctoral Fellow for Research Abroad
  • 2014/08 - 2017/07 University of Pennsylvania Cardiovasular institute Postdoc fellow
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Awards (7)：
  • 2020/10 - 第56回高血圧関連疾患モデル学会学術総会 永井賞
  • 2019/06 - ISHR Richard J Bing Award for Young Investigators
  • 2018/09 - Japanese Circulation Society Basic research grant
  • 2015 - Japan Society for the Promotion of Science Postdoctoral Fellow for Research Abroad
  • 2014 - The Uehara Memorial Foundation Postdoctoral Fellowship
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Association Membership(s) (4)：
日本生化学学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  The Japanese Circulation Society ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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