Yui Naofumi

Affiliation and department：

Research field (1)： Nephrology

Research theme for competitive and other funds (4)：

2018 - 2021 細胞膜輸送体に着目した新しい腎臓線維化治療法の開発
2018 - 2020 細胞膜輸送体に着目した新しい腎臓線維化治療法の開発
2015 - 2018 Identification of molecular mechanisms for AQP2 activation to deveplop its inhibitor
2015 - 2017 直接的アクアポリン2阻害剤の開発

Papers (18)：

Richard Bouley, Naofumi Yui, Abby Terlouw, Pui W Cheung, Dennis Brown. Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells. Cells. 2020. 9. 4
Fumiaki Ando, Shuichi Mori, Naofumi Yui, Tetsuji Morimoto, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Hiroyuki Kagechika, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nature communications. 2018. 9. 1. 1411-1411
Moko Zeniya, Takayasu Mori, Naofumi Yui, Naohiro Nomura, Shintaro Mandai, Kiyoshi Isobe, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1. Scientific reports. 2017. 7. 1. 13086-13086
Wei Li, William W Jin, Kenji Tsuji, Ying Chen, Naohiro Nomura, Limin Su, Naofumi Yui, Julian Arthur, Susanna Cotecchia, Teodor G Paunescu, et al. Ezrin directly interacts with AQP2 and promotes its endocytosis. Journal of cell science. 2017. 130. 17. 2914-2925
Naofumi Yui, Fumiaki Ando, Sei Sasaki, Shinichi Uchida. Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation. Biochemical and biophysical research communications. 2017. 490. 3. 1039-1044

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MISC (41)：

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Lectures and oral presentations (5)：

Regulated Ser-261 Dephosphorylation Combined with Ser-256 and Ser-269 Phosphorulation in the C-terminus of Aquaporin-2 Water Channel
(American Society of Nephrology 2016)
Dephosphorylation at Ser-261 is a determinant for the regulated AQP2 apical accumulation
(Th 48th Annual Meeting of American Society of Nephrology 2015)
Ser-269リン酸化AQP2の細胞内局在の時系列変化
(第 58 回日本腎臓学会学術総会 2015)
Increased Phosphorylation of Ser-269 Is Not Sufficient for Regulated AQP2 Apical Accumulation
(American Society of Nephrology 2014)
BJP lambda-Type Multiple Myeloma Successfully Withdrawn from Maintenance Hemodialysis after Long-Term Continuous Bortezomib and Dexamethasone Therapy
(American Society of Nephrology 2014)

Education (3)：

2006 - 2010 Tokyo Medical and Dental University Graduate School, Division of Medical Sciences
2006 - 2010 東京医科歯科大学大学院医歯学総合研究科腎臓内科学
1994 - 2000 Gunma University Faculty of Medicine School of Medicine

Work history (8)：

2021/05/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - - Visiting Lecturer
2020/05/01 - 2021/04/30 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - - Visiting Lecturer
2019/05/01 - 2020/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - - Visiting Lecturer
2018/05/01 - 2019/04/30 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - - Visiting Lecturer
2017/05/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Systemic Organ Regulation Nephrology Visiting Lecturer

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Association Membership(s) (3)：

日本腎臓学会 , 日本内科学会 , 日本アレルギー学会

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