Suzawa Ken

Affiliation and department：
Job title： assistant professor

Research field (1)： Respiratory surgery

Research theme for competitive and other funds (21)：

2023 - 2027 Genomic abnormalities in the tumor microenvironment and clonal hematopoiesis
2023 - 2027 Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancer
2023 - 2027 Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
2022 - 2027 耐性化機序に基づいたHER2陽性乳癌に対する治療戦略の開発
2023 - 2026 メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明

2023 - 2026 Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application

2022 - 2026 マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討

2022 - 2025 Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response

2022 - 2025 肺がんの胸膜播種進展に関与するがん微小環境の病態解明

2021 - 2024 Exploration of the novel therapeutic target for lung cancer based on the analysis of the characteristics of tumor cells derived from 3D culture

2020 - 2023 家族性肺癌に対する、次世代シーケンサーを用いた胚細胞性遺伝子変異と治療法の探索

2020 - 2023 Development of next-generation precision medicine targeting the pathways on which driver gene mutation-positive lung cancer depends

2019 - 2022 Development of innovative therapeutic strategy for MET-dependent lung cancer

2019 - 2022 Development of a new treatment strategy for HER2-alterated lung cancer

2019 - 2022 Treatment strategy overcoming HER2 targetted drug resistance

2019 - 2022 Development of the novel therapy focused on damage-associated molecular patterns (DAMPs) for lung fibrosis-related diseases

2019 - 2022 Novel treatment strategy for malignant pleural mesothelioma targeting the tumor stem cell marker DCLK1

2018 - 2021 Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors

2018 - 2021 Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancer

2015 - 2018 Development of new therapeutic strategy for EGFR-TKI resistant non-small cell lung cancer.

2014 - 2017 Identification of novel targets in the treatment of lung cancer

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Papers (196)：

Shin Tanaka, Kento Fujii, Megumi Ishihara, Haruki Choshi, Kei Matsubara, Kohei Hashimoto, Shuji Okahara, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, et al. Postoperative Complications in Living Donors for Lung Transplantation. Transplantation direct. 2024. 10. 5. e1617
Yusuke Otani, Haruyoshi Katayama, Yidan Zhu, Rongsheng Huang, Takafumi Shigehira, Kazuhiko Shien, Ken Suzawa, Hiromasa Yamamoto, Tadahiko Shien, Shinichi Toyooka, et al. Adrenergic microenvironment driven by cancer-associated Schwann cells contributes to chemoresistance in patients with lung cancer. Cancer science. 2024
Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Kohei Hashimoto, Shin Tanaka, Kentaroh Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Shinichi Toyooka. Effective division of the intersegmental plane using a robotic stapler in robotic pulmonary segmentectomy. Surgery today. 2024
Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, et al. Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery. Surgery today. 2024
Shinya Katsumata, Mototsugu Shimokawa, Akira Hamada, Naoki Haratake, Kotaro Nomura, Kosuke Fujino, Mao Yoshikawa, Ken Suzawa, Kazuhiko Shien, Kenichi Suda, et al. Impact of central nervous system metastasis after complete resection of lung adenocarcinomas harboring common EGFR mutation - A real-world database study in Japan: The CReGYT-01 EGFR study. European journal of cancer (Oxford, England : 1990). 2024. 201. 113951-113951

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MISC (95)：

T. Habu, H. Yamamoto, K. Nakata, K. Hashimoto, S. Tanaka, K. Suzawa, K. Shien, K. Miyoshi, M. Okazaki, S. Sugimoto, et al. EP07.01-12 A Retrospective Study on the Methods of Covering Bronchial Stump/Anastomotic Site to Avoid the Bronchopleural Fistula after Lung Cancer Surgery. Journal of Thoracic Oncology. 2023. 18. 11. S512-S513
Y. Kubo, S. Sugimoto, H. Choshi, H. Ujike, S. Kawana, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, et al. (258) Histidine-Rich Glycoprotein Ameliorates Lung Ischemia-Reperfusion Injury in a Mouse. The Journal of Heart and Lung Transplantation. 2023. 42. 4. S124-S125
S. Kawana, S. Sugimoto, K. Matsubara, S. Tanaka, K. Miyoshi, H. Choshi, H. Ujike, Y. Kubo, D. Shimizu, K. Hashimoto, et al. (347) Augmented Humoral Response to a Third And Fourth Dose of Mrna Sars-Cov-2 Vaccines in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation. 2023. 42. 4. S164-S165
H. Ujike, S. Tanaka, H. Choshi, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, K. Shien, K. Suzawa, et al. (891) Bilateral Lung Transplantation from Living Donors in a 67-Year-Old Patient. The Journal of Heart and Lung Transplantation. 2023. 42. 4
H. Choshi, K. Miyoshi, H. Ujike, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, et al. (1068) Successful Lung Re-Transplantation with Perioperative Desensitization for Sensitized Recipient with Donor Specific DQ Antibody. The Journal of Heart and Lung Transplantation. 2023. 42. 4. S461-S462

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