Hara Shuntaro

ハラシュンタロウ | Hara Shuntaro

Affiliation and department：
Job title：教授
Research theme for competitive and other funds (22)：

2023 - 2026 Studies on the mechanisms of arsenic-induced vascular and muscular toxicity
2021 - 2025 Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
2019 - 2022 Analysis on molecular mechanisms for tissue-specific toxicity of heavy metals
2016 - 2019 Exploration of novel factors reducing toxicity of environmental chemicals by utilizing toxicolipidomic analyses
2013 - 2016 Development of a novel analysis and evaluation system for environmental chemicals-induced toxicity using toxicolipidomics

2013 - 2015 プロスタグランジン産生関連酵素群の生体内におけるクロストークの解析

2011 - 2013 生命応答制御におけるプロスタグランジン最終合成酵素群の包括的解析

2009 - 2012 Studies on novel mechanisms of environmental chemicals-induced toxicity using arachidonate-metabolizing enzyme genetically modified mice

2007 - 2010 アルツハイマー病巣での膜結合型プロスタグランジンE合成酵素1の生物学的・臨床医学的意義の解析

2007 - 2009 精子に存在するホスホリパーゼA2活性の阻害を介した環境化学物質の新たな内分泌かく乱作用機構に関する研究

2006 - 2008 Functional analysis of phospholipase A2 by genetically modified mice and its biopharmaceutical application

2006 - 2007 CHARACTERIZATION OF ENDOGENOUS HYPDXIA-INDUCED TRANSCRIPTIONAL REPRESSOR HIF-3ALPHA

2006 - 2007 アラキドン酸代謝変動への影響からみた環境化学物質の内分泌かく乱作用機構の解析

2004 - 2005 STUDIES ON FUNCTIONS OF THIOREDOXIN REDUCTASE IN DETOXIFICATION OF HEAVY METALS

2001 - 2002 Studies on Induction and Functions of Thioredoxin Reductase in Stress Responses

1999 - 2000 メタロチオネインによる転写因子のレドックス制御

1998 - 1999 REDOX REGULATION BY ANTIOXIDANTS CONTAINING TRACE ELEMENTS

1995 - 1995 血管機能調節におけるプロスタサイクリン合成酵素の役割の解明

1994 - 1994 血管内皮細胞におけるプロスタサイクリン産生調節機構の解析

1992 - 1994 Molecular Biological Study on the Regulation of Metabolism of Fatty Acid and its Derivatives

1991 - 1991 高等動物細胞II型ホスホリパ-ゼA_2活性制御

1990 - 1990 脂質性メディエーター産生に関与するホスホリパーゼA_2の精製および性状解析

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Papers (128)：

Hiroshi Kuwata, Eriko Nakatani, Yuki Tomitsuka, Tsubasa Ochiai, Yuka Sasaki, Emiko Yoda, Shuntaro Hara. Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock. FASEB Journal. 2023. 37. e23330
Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox biology. 2023. 66. 102850-102850
Hirabayashi, T, Kawaguchi, M, Harada, S, Mouri, M, Takamiya, R, Miki, Y, Sato, H, Taketomi, Y, Yokoyama, K, Kobayashi, T, et al. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl group. Cell Reports. 2023. 42. 2. 111940-111940
Shuntaro Hara. Foreword. Biological & pharmaceutical bulletin. 2022. 45. 8. 978-978
Tsubasa Ochiai, Toshiya Honsawa, Yuka Sasaki, Shuntaro Hara. Prostacyclin Synthase as an Ambivalent Regulator of Inflammatory Reactions. Biological and Pharmaceutical Bulletin. 2022. 45. 8. 979-984

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MISC (157)：

落合翔, 桑田浩, 原俊太郎. Role of acyl-CoA synthetase long-chain family member 4 in the formation of inflammatory diseases in the colon. 日本薬学会年会要旨集(Web). 2023. 143rd
佐々木由香, 落合翔, 遠藤勇気, 鈴木康友, 近藤幸尋, 原俊太郎. Role of microsomal prostaglandin E synthase (mPGES)-1 in chemical-induced bladder carcinogenesis. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
本沢駿弥, 落合翔, 横山知永子, 桑田浩, 原俊太郎. Prostacyclin synthase negatively regulates the inflammatory reactions caused by lipopolysaccharide-induced sepsis in vivo. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
小瀬章太郎, 前本佑樹, 大林翼, 落合翔, 鈴木健裕, 堂前直, 原俊太郎, 伊藤昭博. Functional conversion of acyl CoA synthase ACSL4 by lysine long-chain acylation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
大林翼, 前本佑樹, 小瀬章太郎, 落合翔, 鈴木健裕, 堂前直, 原俊太郎, 伊藤昭博. Regulation of lipid metabolism by lysine long-chain acylation of FATP2. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th

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Books (11)：

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Education (2)：

Professional career (1)：

Work history (10)：

2012/04 - 現在昭和大学薬学部社会健康薬学講座講座責任者
2012/04 - 現在 Showa University Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy Professor
2009/03 - 2012/03 Showa University Department of Health Chemistry, School of Pharmaceutical Sciences Professor
2007/04 - 2009/03 Showa University Department of Health Chemistry, School of Pharmaceutical Sciences Associate Professor
2005/07 - 2007/03 Showa University Department of Health Chemistry, School of Pharmaceutical Sciences Associate Professor

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Committee career (21)：

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