2018 - 2021 Elucidation of the mechanism by which paxillin controls vascular abnormal contraction
2016 - 2019 Elucidation of the involvement of calpain and cytoskeletal proteins in the signal transduction of abnormal vascular smooth muscle contraction
2015 - 2018 Searching for the novel signalling molecule in vascular abnormal contraction
2013 - 2016 Elucidation of the shared signaling pathways for intractable diseases in terms of cytoskeletal rearrangements
2013 - 2015 Research for novel signaling molecule involving vascular smooth muscle abnormal contraction
2011 - 2015 Identification of food component which selectively inhibits abnormal vascular contraction
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Papers (18)：
Ying Zhang, Huanyu Zheng, Ming Xu, Noriko Maeda, Ryouichi Tsunedomi, Hiroko Kishi, Hiroaki Nagano, Sei Kobayashi. Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells. International journal of molecular sciences. 2023. 24. 21
Ying Zhang, Hiroko Kishi, Sei Kobayashi. Direct active Fyn-paxillin interaction regulates vascular smooth muscle cell migration. Journal of Smooth Muscle Research. 2023. 59. 58-66
Nan Li, Ying Zhang, Tomoka Morita, Hiroko Kishi, Sei Kobayashi. Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction. Journal of Pharmacological Sciences. 2022. 149. 4. 189-197
Ying Zhang, Qian Lu, Nan Li, Ming Xu, Tatsuo Miyamoto, Jing Liu. Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. NPJ breast cancer. 2022. 8. 1. 40-40
Kosuke Hosoba, Tomoka Morita, Ying Zhang, Hiroko Kishi, Takashi Yamamoto, Tatsuo Miyamoto. High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies. Methods in Cell Biology. 2022
