Arima Yoshimi

アリマヨシミ | Arima Yoshimi

Affiliation and department：
Job title： Assistant Professor/Senior Assistant Professor

Research field (1)： Tumor biology

Research theme for competitive and other funds (6)：

2020 - 2023 不均一な乳がんに特異的な腫瘍抗原の同定と免疫細胞活性化メカニズムの解明
2016 - 2019 Cancer cell interaction mechanisms caused by the complexity of breast cancer tissues
2013 - 2016 RNA Sequencing Analysis of Distant Metastasis of Breast Cancer Cells
2011 - 2012 Analysis of cancer stem cell properties andepithelial-mesenchymal transition signals in recurrence and metastasis of breast cancer cells
2009 - 2010 Significance of Rb pathway in the epithelial to mesenchymal transition inducing cancer invasion and metastasis

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Papers (52)：

Haruki Inoue, Eriko Aimono, Akiyoshi Kasuga, Haruto Tanaka, Aika Iwasaki, Hideyuki Saya, Yoshimi Arima. Pixel-Level Clustering of Hematoxylin-Eosin-Stained Sections of Mouse and Human Biliary Tract Cancer. Biomedicines. 2022. 10. 12
Ritsuko Harigai, Ryo Sato, Chikako Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Takanori Hirose, Hideyuki Saya, Yoshimi Arima. Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation. Cancers. 2022. 14. 10. 2377-2377
Ryo Sato, Kosuke Imamura, Takashi Semba, Yusuke Tomita, Sho Saeki, Koei Ikeda, Yoshihiro Komohara, Makoto Suzuki, Takuro Sakagami, Hideyuki Saya, et al. TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma. Cancer Research. 2021. 81. 18. 4751-4765
Akiyoshi Kasuga, Takashi Semba, Ryo Sato, Hiroyuki Nobusue, Eiji Sugihara, Hiromasa Takaishi, Takanori Kanai, Hideyuki Saya, Yoshimi Arima. Oncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Science. 2021. 112. 5. 1822-1838
Takashi Semba, Ryo Sato, Akiyoshi Kasuga, Kentaro Suina, Tatsuhiro Shibata, Takashi Kohno, Makoto Suzuki, Hideyuki Saya, Yoshimi Arima. Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d. Cancers. 2020. 12. 12

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MISC (14)：

吉川桃子, 吉川桃子, 黄地健仁, 森川暁, 芝田晋介, 高橋萌, 相馬智也, 宮下英高, 村岡渡, 亀山香織, et al. 口腔に発生した再発紡錘細胞癌における間葉系幹細胞の同定. 頭頸部癌. 2019. 45. 2. 158-158
吉川桃子, 黄地健仁, 森川暁, 芝田晋介, 高橋萌, 相馬智也, 宮下英高, 村岡渡, 亀山香織, 河奈裕正, et al. 口腔に発生した再発紡錘細胞癌における間葉系幹細胞の同定. 頭頸部癌. 2019. 45. 2. 158-158
Takashi Semba, Ryo Sato, Makoto Suzuki, Hideyuki Saya, Yoshimi Arima. EpCAM positive lung cells are involved in organoid formation. CANCER RESEARCH. 2016. 76
Ryo Sato, Takashi Semba, Hirotsugu Kohrogi, Hideyuki Saya, Yoshimi Arima. The association between gastric Mucin 5AC (MUC5AC) expressions, transforming growth factor-beta (TGF-beta) signal, and histopathological phenotypes of lung cancer in xenograft models. CANCER RESEARCH. 2016. 76
Yoshimi Arima, Kenjiro Kosaki, Chikako Hirose, Hideyuki Saya. Additional mutations in genes relevant to the Ras signaling pathway promote the malignant characteristics of NF1-associated malignant peripheral nerve sheath tumor (NF1-MPNST) cells. CANCER RESEARCH. 2015. 75

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Patents (6)：

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Lectures and oral presentations (47)：

CDK4/6阻害剤によるがん細胞制御
(第30回日本乳癌学会学術総会 2022)
PTPN11変異はRas/MAPK経路を活性化してNF1欠損細胞の悪性進行をもたらし、BRAP変異によって抑制される
(第13回日本レックリングハウゼン病学会学術大会 2022)
Approach to identifying the molecular mechanisms of refractory heterogeneous cancers based on mouse models
(2021)
CDK4/6阻害剤によるがん細胞制御
(第18回日本臨床腫瘍学会学術集会 2021)
神経線維腫に対する治療薬の開発(教育講演)
(第11回日本レックリングハウゼン病学会学術大会 2020)

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Professional career (1)：

Awards (3)：

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