Sekiya Mizuki

Affiliation and department：

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (12)：

2021 - 2025 Molecular mechanism underlying organelle trafficking regulated by stractually diverse proton pump vacolar ATPase
2021 - 2024 Ion transport network in oral pathogenic bacteria
2019 - 2022 Common principle of secretory lysosome transport and universal mechanism of organelle trafficking
2018 - 2021 A novel approach to drug development targeting to proton pumping ATPase
2016 - 2018 Exploitation of proton pumping ATPase inhibitors in oral cavity pathogenic bacteria

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Papers (28)：

Mizuki Sekiya, Kazuya Ikeda, Ayaka Yonai, Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama, Minoru Sasaki, Mayumi Nakanishi-Matsui. F-type proton-pumping ATPase mediates acid tolerance in Streptococcus mutans. Journal of applied microbiology. 2023. 134. 4. lxad073
Mizuki Sekiya. Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors. Biological & pharmaceutical bulletin. 2022. 45. 10. 1404-1411
Naomi Matsumoto, Mizuki Sekiya, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui. The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts. Scientific reports. 2022. 12. 1. 8455-8455
関谷瑞樹, 村松美音, 山口友聖, 下山佑, 石河太知, 古玉芳豊, 佐々木実, 中西真弓[松井]. 口腔レンサ球菌Streptococcus anginosusのプロトン輸送ATPaseによる耐酸性発現メカニズム. 日本薬学会年会要旨集. 2022. 142年会. 27H-pm01
關谷瑞樹, 山口友聖, 村松美音, 村上幸汰, 高坂未星, 下山佑, 石河太知, 古玉芳豊, 河野貴久子, 矢野志緒, et al. Streptococcus anginosus F型プロトン輸送ATPaseの酸性環境における役割. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [3T15m-363)]

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MISC (5)：

後藤(松元)奈緒美, 関谷瑞樹, 和田(孫)戈虹, 和田洋, 河上裕, 中西(松井)真弓. プロトンポンプV-ATPaseのa3サブユニットによる小胞輸送関連因子Mon1-Ccz1の分泌リソソームへのリクルート. 国際医療福祉大学学会誌. 2022. 27
阪本泰光, 日高興士, 石原司, 中村彰宏, 鈴木義之, 關谷瑞樹, 六本木沙織, 小笠原渉, 田中信忠. Development of inhibitors with a novel mechanism of action targeting S46 DPPs in nonfermenting pathogens. 放射光. 2022. 35. 2. 88-96
關谷瑞樹, 泉澤信太郎, 櫛桁安生, 芳賀雅人, 下山佑, 石河太知, 佐々木実, 佐々木由香, 岩本(木原)昌子, 中西(松井)真弓. プロトン輸送F-ATPase阻害剤によるStreptococcus mutansの耐酸性の低下. 日本生化学会大会(Web). 2018. 91st. ROMBUNNO.2P-145 (WEB ONLY)-145]
Mizuki Sekiya, Robert K. Nakamoto, Mayumi Nakanishi-Matsui, Masamitsu Futai. The Phytopolyphenol Piceatannol Inhibits the Rate Limiting Step of Rotational Catalysis of the F1-ATPase. BIOPHYSICAL JOURNAL. 2012. 102. 3. 711A-711A
中西真弓, 關谷瑞樹. プロトンポンプATPaseの回転触媒機構. 日本応用酵素協会誌. 2011. 45. 45. 11-18

Work history (3)：

Association Membership(s) (2)：

The Japanese Biochemical Society , The Pharmaceutical Society of Japan

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