Research field (4)：
Molecular biology
, Environmental effects of chemicals
, Environmental effects of radiation
, Pharmaceuticals - health and biochemistry
Research keywords (3)：
クロマチンリモデリング
, 転写
, DNA修復
Research theme for competitive and other funds (5)：
2017 - 2019 Investigation of the mechanism underlying the association between DSB repair and Transcription
2014 - 2017 Function of MLL fusion partner ENL in DSB repair
2012 - 2014 LKB1-AMPK2 signaling promotes non-homologous end joining by regulating SWI/SNF chromatin remodeling
Papers (35)：
Junya Tabata, Takashi Nakaoku, Mitsugu Araki, Ryunosuke Yoshino, Shinji Kohsaka, Ayaka Otsuka, Masachika Ikegami, Ayako Ui, Shin-Ichiro Kanno, Keiko Miyoshi, et al. Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis. Cancer research. 2022. 82. 20. 3751-3762
Huicheng Qi, Megumi Kikuchi, Yuki Yoshino, Zhenzhou Fang, Kazune Ohashi, Takato Gotoh, Ryo Ideta, Ayako Ui, Shino Endo, Kei Otsuka, et al. BRCA1 transports the DNA damage signal for CDDP-induced centrosome amplification through the centrosomal Aurora A. Cancer science. 2022. 113. 12. 4230-4243
Hiroki Fujita, Masanori Ikeda, Ayako Ui, Yunosuke Ouchi, Yoshiko Mikami, Shin-ichiro Kanno, Akira Yasui, Kozo Tanaka. CHAMP1-POGZ counteracts the inhibitory effect of 53BP1 on homologous recombination and affects PARP inhibitor resistance. Oncogene. 2022
Takeshi Yasuda, Kazuya Takizawa, Ayako Ui, Michio Hama, Wataru Kagawa, Kaoru Sugasawa, Katsushi Tajima. Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 5. 328-335
宇井彩子. Chromatin remodeler, ISWI, moves nucleosomes to promote Homologous Recombination, and mobilizes DNA polymerase at DSBs. 第41回染色体ワークショップ・第22回核ダイナミクス研究会要旨集. 2024
