Rchr
J-GLOBAL ID:201801009385073840
Update date: Dec. 07, 2024 Wakabayashi Yuichi
Wakabayashi Yuichi
Affiliation and department: Job title:
部長
Research field (1):
Experimental pathology
Research keywords (3):
squamous cell carcinoma
, chemical carcinogenesis
, mouse model
Research theme for competitive and other funds (21): - 2023 - 2026 遺伝学的スクリーニングによるPAK1阻害の効果を増強する因子の探索
- 2022 - 2025 神経幹細胞による大脳発生と脳腫瘍発症機構の解明
- 2022 - 2025 表皮および樹状細胞間のがん微小環境におけるクロストーク解析
- 2019 - 2023 Anti-cancer therapies aiming for cure through inhibiting tumor-specific responses to environmental fluctuation
- 2019 - 2023 発がん感受性に寄与する表皮細胞とランゲルハンス細胞間の相互作用解析
- 2018 - 2023 多段階発がん過程におけるMeis1経路の網羅的機能解析
- 2018 - 2022 Analysis of neuronal tumorigenesis using mouse models
- 2015 - 2018 Analysis of mechanisms to develop hydrocephalus using mice model
- 2015 - 2018 Elucidation of the mechanisms of carcinogenesis regulated by oxidative stress response
- 2015 - 2018 Identification of cancer-related gene polymorphisms by genetic integration of mouse and human
- 2015 - 2018 Transactions of telomere components
- 2010 - 2016 Telomere Functions in Cancer Development
- 2013 - 2015 Identification of resistance genes in the process of tumor progression
- 2011 - 2015 Comprehensive analysis of functional non-coding RNAs in cancer genome on multistage carcinogenesis
- 2011 - 2013 Meis1 regulates epidermal stem cells and is required for skin tumorigenesis
- 2011 - 2012 The elucidation of carcinogenic mechanism by two-stage skin carcinogenesis in CENP-R null mice
- 2010 - 2012 Functional study on the regulatory role of reactive oxygen species-generating oxidase Nox1 in cancer development
- 2002 - 2002 モデルマウスを用いた加齢性難聴原因遺伝子のポジショナルクローニング
- 2001 - 2002 難聴マウス、nsマウス原因遺伝子のポジショナルクローニング
- 2001 - 2001 モデルマウスを用いた聴覚障害原因遺伝子のポジショナルクローニング
- 1999 - 2000 突然変異により誕生した新しい難聴マウスのゲノム解析
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Papers (46): -
Weixia Kong, Masatoshi Hara, Yurika Tokunaga, Kazuhiro Okumura, Yasuhiro Hirano, Jiahang Miao, Yusuke Takenoshita, Masakazu Hashimoto, Hiroshi Sasaki, Toshihiko Fujimori, et al. CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation. Life science alliance. 2025. 8. 1
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Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Yoshinori Hasegawa, et al. Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model. Cancer science. 2024
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Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi. Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation. The Journal of investigative dermatology. 2022. 142. 9. 2323-2333
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Eriko Isogai, Kazuhiro Okumura, Megumi Saito, Yurika Tokunaga, Yuichi Wakabayashi. Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum. Biomedical research (Tokyo, Japan). 2022. 43. 3. 91-97
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Megumi Saito, Akane Sada, Masaki Fukuyo, Kiyono Aoki, Kazuhiro Okumura, Yuko Tabata, Yu Chen, Atsushi Kaneda, Yuichi Wakabayashi, Rieko Ohki. PHLDA3 is an important downstream mediator of p53 in squamous cell carcinogenesis. The Journal of investigative dermatology. 2021
more... MISC (62): -
奥村和弘, 盛永敬郎, 田中青空, 音山敬祐, 徳永夕莉香, 斎藤慈, 荒木喜美, 若林雄一. Deletion of Pak1 enhances anti-tumor immunity by the activation of dendritic cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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若林雄一, 奥村和弘, 斎藤慈, 徳永夕莉香, 音山敬祐, 田中青空. Identification of STMM loci controlling DMBA/TPA-induced skin tumors. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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奥村和弘, 齋藤慈, 徳永夕莉香, 磯貝恵理子, 荒木喜美, 若林雄一. Pak1-3’UTRの機能的多型は選択的ポリアデニル化を介して皮膚腫瘍感受性を制御する. 日本実験動物学会総会講演要旨集(Web). 2022. 69th
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奥村和弘, 齋藤慈, 磯貝恵理子, 荒木喜美, 若林雄一. Pak1の3’UTR多型は代替ポリアデニル化を制御しマウス皮膚がん感受性に影響を与える. 日本癌学会学術総会抄録集(Web). 2021. 80th
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奥村和弘, 斎藤慈, 吉澤康博, 磯貝恵理子, 若林雄一. ランゲルハンス細胞のPak1遺伝子は皮膚幹細胞の維持に関与し多段階皮膚発がんを制御する. 第79回日本癌学会学術総会プログラム集. 2020. 170-170
more... Education (2): - 1994 - 1998 新潟大学院医学研究科博士課程
- 1988 - 1994 Niigata University Faculty of Medicine
Work history (6): Committee career (2): - 2019/04 - 2025/03 日本癌学会 評議員
- 2021/08 - 2023/07 日本生化学会 関東地区代議員
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