Rchr
J-GLOBAL ID：201801009420466698   Update date: Nov. 19, 2024

Mochida Yuki

モチダ ユウキ | Mochida Yuki
Affiliation and department：
Institute of Science Tokyo Medical Research Institute, Department of Advanced Nanomedical Engineering

About Institute of Science Tokyo Medical Research Institute, Department of Advanced Nanomedical Engineering


Job title： Junior Associate Professor
Other affiliations (1)：
  • Kawasaki Institute of Industrial Promotion  Innovation Center of NanoMedicine   Dupty Principal Research Scientist
Research field  (7)： Biomedical engineering ,  Polymer chemistry ,  Clinical pharmacy ,  Pharmaceuticals - analytical and physicochemistry ,  Polymer materials ,  Biochemistry ,  Analytical chemistry
Research keywords  (10)： ドラッグデリバリーシステム ,  protein delivery ,  mRNA delivery ,  がん免疫療法 ,  oral delivery ,  高分子構造・物性 ,  高分子ミセル ,  イオン液体 ,  ナノメディシン ,  白金錯体
Research theme for competitive and other funds  (18)：
  • 2024 - 2028 Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors
  • 2022 - 2026 Development of intracellular antibody delivery systems for intracellular immune checkpoint blockade therapy
  • 2024 - 2026 悪性脳腫瘍の高度治療抵抗性を克服する次世代ADCの開発
  • 2023 - 2026 Development of multidisciplinary immunotherapy utilizing NK cells in combination with PEG-conjugated immune checkpoint antibodies
  • 2023 - 2026 高精度細胞内送達機能を実装する高分子ミセルを用いた革新的がんゲノム編集療法の開発
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Papers (32)：
  • Yukine Ishibashi, Mitsuru Naito, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata. Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation. Bioconjugate chemistry. 2024
  • Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida. Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular Therapy. 2024. 32. 5. 1266-1283
  • Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral. Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angewandte Chemie (International ed. in English). 2024. 63. 14. e202317817
  • Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024. 21. 1. 1-27
  • Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, et al. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery. Small Science. 2024
ｍore...
MISC (1)：
  • 持田祐希, 河本佑介. DDSの「ちょっとした」技術・知識 高速液体クロマトグラフィー(HPLC). Drug Delivery System. 2023. 38. 4. 329-333
Patents (8)：
  • 抗原への結合親和性を低減させた抗体
  • 抗原への結合親和性を低減させた抗体
  • 共重合体、該共重合体の製造方法、およびカルボキシ基またはその塩を有する共重合体の製造方法
  • PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF BRAIN TUMOR COMPRISING EPIRUBICIN MICELLE, AND USE THEREOF
  • ブロックコポリマー、ミセル組成物、及び医薬組成物
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Books (4)：
  • 医薬品モダリティにおける創薬技術開発と展望
    情報機構 2024 ISBN:9784865022711
  • バイオマテリアル学会誌-生体材料-40巻1号
    日本バイオマテリアル学会 2022
  • 未来をつくる仕事図鑑
    学研プラス 2021
  • 現代界面コロイド化学の基礎 第4版
    丸善出版 2018 ISBN:9784621302910
Lectures and oral presentations  (19)：
  • 精密ドラッグデリバリーが切り拓く難治がん治療
    (CANCER IMMUNOTHERAPY FOR BRAIN TUMOR IN NARA 2024)
  • mRNAの精密PEG修飾による脾臓ターゲティング
    (日本核酸医薬学会第9回年会 2024)
  • 悪性脳腫瘍に有効な免疫チェックポイント阻害薬の開発とmRNAワクチンの脾臓デリバリー
    (iCONM/CHANGE学術セミナー 2024)
  • スマートPEG化抗体による悪性脳腫瘍の免疫療法
    (第2回生命理工-難研シンポジウム 2024)
  • 難治がん治療に向けた抗体ポリマー複合体の開発
    (日本薬学会第144年会 2024)
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Works (1)：
  • エメラルド
    持田祐希 2007 - 現在
Education (5)：
  • 2011 - 2014 The University of Tokyo The Graduate School of Engineering Department of Bioengineering
  • 2009 - 2011 The University of Tokyo The Graduate School of Engineering Department of Bioengineering
  • 2007 - 2009 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
  • 2005 - 2007 The University of Tokyo College of Arts and Sciences
  • 2002 - 2005 鳥取県立米子東高等学校
Professional career (1)：
  • Ph.D. (Engineering) (The University of Tokyo)
Work history (10)：
  • 2024/10 - 現在 Institute of Sciecne Tokyo Department of Nanobiomedical Engineering, Medical Research Laboratory, Institute of Integrated Research Junior Associate Professor
  • 2023/04 - 現在 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine Dupty Principal Research Scientist
  • 2023/04 - 2024/09 Tokyo Medical and Dental University Medical Research Institute, Department of Advanced Nanomedical Engineering Junior Associate Professor
  • 2015/06 - 2023/03 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine Senior Research Scientist
  • 2015/06 - 2018/09 川崎市産業振興財団 ナノ医療イノベーションセンター 企画・技術支援チーム(兼任)
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Awards (9)：
  • 2024/07 - 日本がん免疫学会 若手研究奨励賞
  • 2023/07 - The Society of Polymer Science, Japan IPC2023 Young Scientist Poster Award
  • 2022/11 - Nano Biomedical Society Nano Biomedical Society Award
  • 2021/06 - 日本DDS学会 第37回日本DDS学会学術集会優秀発表賞
  • 2021/01 - Best Presentation Award - 15th COINS General meeting
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Association Membership(s) (8)：
日本核酸医薬学会 ,  Japanese Cancer Association ,  The Antibody Society of Japan ,  Japanese Association of Cancer Immunology ,  The Pharmaceutical Society of Japan ,  THE JAPANESE SOCIETY FOR BIOMATERIALS ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  THE SOCIETY OF POLYMER SCIENCE, JAPAN
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