Rchr
J-GLOBAL ID：201801009453871903
Update date: Jan. 30, 2024
Kawaguchi Makiko
Kawaguchi Makiko
Affiliation and department：
Job title：
Assistant Professor
Research field (1)：
Experimental pathology
Research theme for competitive and other funds (7)：
Papers (40)：
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Caroline A Enns, Tyler Weiskopf, Richard H Zhang, Jeffrey Wu, Shall Jue, Makiko Kawaguchi, Hiroaki Kataoka, An-Sheng Zhang. Matriptase-2 regulates iron homeostasis primarily by setting the basal levels of hepatic hepcidin expression through a nonproteolytic mechanism. The Journal of biological chemistry. 2023. 299. 10. 105238-105238
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Roman Szabo, Makiko Kawaguchi, Hiroaki Kataoka, Thomas H Bugge. Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM. Development (Cambridge, England). 2023. 150. 17
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Makiko Kawaguchi, Hiroaki Kataoka, Takumi Kiwaki, Liang Weiting, Sayaka Nagata, Kazuo Kitamura, Tsuyoshi Fukushima. Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin-4 expression in the colonic epithelium. FEBS open bio. 2023. 13. 4. 713-723
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Kenjirou Ogawa, Karin Urata, Saki Maeda, Yuta Ohno, Keitaro Satoh, Yoshiyuki Yamada, Yosuke Suzuki, Yasuko Koga, Kazuhiro Sugamoto, Makiko Kawaguchi, et al. Blueberry Leaf Extract Prevents Lacrimal Hyposecretion in Sjögren's Syndrome-like Model of Non-obese Diabetic Mice. In vivo (Athens, Greece). 2023. 37. 1. 149-162
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Fumiki Yamashita, Takashi Kaieda, Takeshi Shimomura, Makiko Kawaguchi, Chen-Yong Lin, Michael D Johnson, Hiroyuki Tanaka, Takumi Kiwaki, Tsuyoshi Fukushima, Hiroaki Kataoka. Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1. The FEBS Journal. 2022. 289. 12. 3422-3439
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MISC (10)：
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Kataoka H, Kawaguchi M, Fukushima T, Shimomura T. Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): emerging key players in epithelial integrity and cancer. Pathology International. 2018. 68. 3. 145-158
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Tsuyoshi Fukushima, Jingjia Ye, Makiko Kawaguchi, Yukihiro Haruyama, Ai Kanemaru, Koji Yamamoto, Hiroaki Kataoka. Silencing of membrane-bound serine protease inhibitor, HAI-1, enhances metastatic capability of pancreatic cancer cells in mouse models. CLINICAL & EXPERIMENTAL METASTASIS. 2015. 32. 3. 202-202
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Hiroaki Kataoka, Makiko Kawaguchi, Ai Kanemaru, Tsuyoshi Fukushima, Nobuhiro Matsumoto, Masamitsu Nakazato. Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice. CANCER RESEARCH. 2014. 74. 19
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Yukihiro Haruyama, Jing-Jia Ye, Makiko Kawaguchi, Ai Kanemaru, Tsuyoshi Fukushima, Hiroaki Kataoka. Hepatocyte growth factor activator inhibitor type 1 suppresses invasion of pancreatic adenocarcinoma cells through inhibition of matriptase/protease-activated receptor-2 axis. CANCER RESEARCH. 2014. 74. 19
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片岡寛章, 川口真紀子, 田中弘之, 福島 剛. プロテアーゼによるがん間質モジュレーション. 病理と臨床. 2014. 32. 1. 31-36
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Lectures and oral presentations (13)：
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HAI-1 は proteasxe activated receptor-2 (PAR-2) を介して表皮及び毛髪の形態形成を維持する
(2017年度生命科学系学会合同年次大会 2017)
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Excess activation of PAR-2 increased frequency of tumor formation in HAI-1 deficient ApcMin+ mice
(第76回日本癌学会学術総会 2017)
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Accelerated tumor formation induced by Hai-1 deficiency in the ApcMin/+ model is prevented by concomitant deficiency of Par-2
(ASBMB Special Symposia Series; Membrane-Anchored Serine Protease 2017)
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HAI-1欠損はPAR-2シグナル活性化を介して腸管発癌を亢進させる
(第22回日本病態プロテアーゼ学会学術集会 2017)
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表皮及び毛髪の形態形成の諸段階におけるHAI-1発現の意義に関する検討
(第106回日本病理学会総会 2017)
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Education (1)：
- - 2010 University of Miyazaki Graduate School, Division of Medical Sciences
Professional career (1)：
Work history (1)：
- 2015/04/01 - 現在 University of Miyazaki Faculty of Madicine School of Madicine Pathology course tumor and reproduction condition study field Assistant Professor
Association Membership(s) (5)：
日本分子生物学会
, 日本病態プロテアーゼ学会
, 日本癌学会
, 日本病理学会
, AACR
