Rchr
J-GLOBAL ID:201801009481024825
Update date: Dec. 13, 2024
Mori Yutaro
モリ ユウタロウ | Mori Yutaro
Affiliation and department:
Job title:
Tenure-Track Assistant Professor
Research field (6):
Biomedical engineering
, Nephrology
, Internal medicine - General
, Clinical pharmacy
, Physiology
, Medical biochemistry
Research keywords (7):
Micro Physiological System
, 3D culture
, disease modeling
, COVID-19
, diabetic kidney disease
, chronic kidney disease
, autophagy
Research theme for competitive and other funds (22):
- 2023 - 2028 尿細管上皮細胞をターゲットとした新規の糖尿病性腎臓病治療薬の開発
- 2024 - 2027 炎症、線維化および老化に関する、細胞外小胞(EV)を用いた治療用製剤の開発
- 2024 - 2027 Elucidation of Pathophysiology and Drug Development for Chronic Kidney Disease by Using Kidney-on-a-chip Derived from Patients
- 2023 - 2026 免疫チェックポイント分子の制御による慢性腎臓病の新規治療法開発
- 2022 - 2026 Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules
- 2024 - 2025 1. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬 2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明 3. ヒト摘出腎由来尿細管オルガノイドによる各種の新規腎疾患モデルの作製とkidney-on-a-chip樹立
- 2024 - 2025 患者由来腎臓尿細管オルガノイドのメタボローム解析
- 2023 - 2025 マイクロ流体デバイスを用いた慢性腎臓病患者由来kidney-on-a-chipの樹立
- 2023 - 2025 尿細管オルガノイドを用いた慢性腎臓病病態モデルの開発と病因細胞のプロファイリング
- 2023 - 2024 Development of treatment for diabetic kidney disease by combination of KIM-1 inhibitor and SGLT2 inhibitor
- 2024 - 2024 慢性腎臓病患者由来kidney-on-a-chipの開発
- 2023 - 2024 Elucidation of pathophysiology of diabetic kidney disease focusing on intracellular glucose metabolism
- 2023 - 2024 ヒト患者由来の薬剤腎臓毒性試験プラットフォームの開発
- 2023 - 2024 1. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬/2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明/3. ヒト摘出腎由来尿細管オルガノイドによる各種の新規腎疾患モデルの作製
- 2022 - 2024 Development of semi-personalized disease modeling based on renal tubular organoids
- 2022 - 2023 初代培養オルガノイドによる薬剤テスト
- 2022 - 2023 細胞老化と免疫チェックポイント分子をターゲットとした慢性腎臓病の病態解明
- 2021 - 2022 Kidney Injury Molecule-1 in Epithelial Repair
- 2020 - 2022 Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids
- 2019 - 2020 Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery
- 2015 - 2018 ハーバード大学との戦略的提携による器官恒常性破綻病態に対する新規治療法の開発
- 2016 - 2017 Elucidation of regulatory mechanism for WNK kinase, blood pressure and electrolytes by autophagy
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Papers (52):
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Yuta Nakano, Shintaro Mandai, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Kiyohide Fushimi, et al. Nationwide mortality following acute type B aortic dissection and the survival advantage of obesity among dialysis patients in Japan. Journal of Nephrology. 2024
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Tomoki Yanagi, Hiroaki Kikuchi, Koh Takeuchi, Koichiro Susa, Takayasu Mori, Motoko Chiga, Kouhei Yamamoto, Asuka Furukawa, Takumi Kanazawa, Yuki Kato, et al. ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease. Kidney International. 2024. 106. 5. 887-906
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Takayasu Mori, Takuya Fujimaru, Chunyu Liu, Karynne Patterson, Kouhei Yamamoto, Takefumi Suzuki, Motoko Chiga, Akinari Sekine, Yoshifumi Ubara, Danny E Miller, et al. CFAP47 is a causative gene implicated in X-linked polycystic kidney disease. Kidney International Reports. 2024. In press
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Makiko Mori, Yutaro Mori, Yuki Nakao, Shintaro Mandai, Tamami Fujiki, Hiroaki, Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, et al. Adult renal tubular organoids can be produced from different human individuals in a completely same protocol. medRxiv. 2024. 2024.08.11.24311846
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Makiko Mori, Yutaro Mori, Yuki Nakao, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, et al. Development of adult renal tubular organoids from different human individuals in a single medium. JMA Journal. 2024. in press
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MISC (122):
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仲尾 祐輝, 森 槙子, 森 雄太郎. 慢性腎臓病(CKD)創薬を加速させるヒト患者由来尿細管オルガノイド. BIO Clinica. 2025. 40. 1. 90-95
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鈴木 健文, 須佐 紘一郎, 柳 智貴, 中野 雄太, 原 悠, 藤木 珠美, 菊池 寛昭, 安藤 史顕, 萬代 新太郎, 森 雄太郎, et al. ヒトiPS細胞を用いたネフロン癆病態モデル腎オルガノイドの作製. 日本腎臓学会誌. 2024. 66. 4. 572-572
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中野 雄太, 萬代 新太郎, 森 雄太郎, 安藤 史顕, 森 崇寧, 須佐 紘一郎, 飯盛 聡一郎, 内藤 省太郎, 蘇原 映誠, 伏見 清秀, et al. 急性大動脈解離による国内11年間の緊急透析リスクと性差. 日本腎臓学会誌. 2024. 66. 4. 677-677
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鈴川 礼奈, 萬代 新太郎, 中野 雄太, 森 雄太郎, 安藤 史顕, 森 崇寧, 須佐 絋一郎, 飯盛 総一郎, 内藤 省太郎, 蘇原 映誠, et al. 降圧薬クラスの選択が外科手術後の生命予後・ADL転帰を変える. 日本腎臓学会誌. 2024. 66. 4. 628-628
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藤丸 拓也, 蘇原 映誠, 森 崇寧, 関根 章成, 千賀 宗子, 萬代 新太郎, 菊池 寛昭, 森 雄太郎, 原 悠, 藤木 珠美, et al. PKHD1のヘテロ接合性バリアントは常染色体顕性多発性囊胞腎の原因となり得る. 日本腎臓学会誌. 2024. 66. 4. 627-627
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Books (1):
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浮腫 : 塩・水過剰、新たな展開とは?
医薬ジャーナル社 2014 ISBN:9784753227037
Lectures and oral presentations (176):
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透析患者の機能不全腎より得られた初代培養腎尿細管上皮細胞からのチュブロイド作製
(第14回腎不全研究会 2024)
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老化細胞除去薬かつKIM-1によるエンドサイトーシスの阻害薬であるTW-37は、KIM-1の発現、NF-κB-IL-1β経路、PD-L1免疫チェックポイントリガンドの発現、および細胞老化を抑制する
(第14回腎不全研究会 2024)
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SGLT2阻害薬の尿細管上皮に対する腎保護作用の解明
(第14回腎不全研究会 2024)
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腎癌・慢性腎臓病に共通したKIM-1による免疫寛容制御機構の解明
(第14回腎不全研究会 2024)
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Monoallelic PKHD1 Loss-of-Function Variants Could Be a Cause of Adult Polycystic Kidney Disease
(Kidney Week 2024 2024)
more...
Works (2):
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替えきかぬ 細胞だけに 菌生える
森 雄太郎 2024 - 2024
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渾身の 高額実験 ネガデータ
森 雄太郎 2024 - 2024
Education (4):
- 2012 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Doctoral Program: Medical and Dental Sciences Track
- 2002 - 2008 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- 1999 - 2002 青雲高等学校 普通科
- 1996 - 1999 長崎大学教育学部附属中学校
Professional career (2):
- PhD (Tokyo Medical and Dental University)
- MD (Tokyo Medical and Dental University)
Work history (14):
- 2024/10 - 現在 Institute of Sciecne Tokyo Graduate School of Medical and Dental Sciences Track of Medical and Dental Sciences Tenure-Track Assistant Professor
- 2022/02 - 2024/09 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Medical and Dental Sciences Assistant Professor, Tenure Track
- 2020/04 - 2022/01 Japan Society for the Promotion of Science Overseas Research Fellow
- 2018/04 - 2022/01 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / Research Fellow (BWH)
- 2016/04 - 2019/03 Tokyo Medican and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Adjunct Lecturer
- 2017/04 - 2018/03 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / POI Sponsored Collaborator (BWH)
- 2015/11 - 2017/03 Tsuchiura Kyodo General Hospital Associate Physician in Nephrology
- 2015/11 - 2016/05 Namegata District General Hospital (Present: Tsuchiura Kyodo General Hospital Namegata District Medical Center)
- 2015/04 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Research Assistant
- 2012/07 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Medical Hospital Clinical Assistant
- 2014/04 - 2015/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Teaching Assistant
- 2010/04 - 2012/03 Tsuchiura Kyodo General Hospital Clinical Fellow in Nephrology
- 2009/04 - 2010/03 Tokyo Medical and Dental University Professional Development Center, Medical Hospital Resident
- 2008/04 - 2009/03 Shuwa General Hospital Resident
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Committee career (5):
- 2020/04 - 現在 The Japanese Society of Internal Medicine Committee Member of Peer Review for Clinical Summary in Board Certification Examination
- 2017/04 - 現在 Japanese Society of Nephrology Councillor
- 2022/04 - 2024/03 Tokyo Medical and Dental University Open Innovation Promotor
- 2022/09 - 2022/09 国立大学法人 東京医科歯科大学 仕様策定委員
- 2015/04 - 2017/03 一般社団法人 日本内科学会 病歴要約1次評価委員
Awards (15):
- 2024/05 - 株式会社EXORPHIA バイオベンチャーあるある川柳大賞 オーディエンス賞 渾身の 高額実験 ネガデータ
- 2024/04 - The Japanese Society of Internal Medicine Outstanding Instructor Award A case of nephrotic syndrome associated with membranous proliferative glomerulonephritis in post-remission IgA nephropathy, which went into remission with immunosuppressive drugs
- 2024/01 - バソプレシン・オキシトシン研究会 第33回バゾプレシン・オキシトシン研究会 研究奨励賞 LRBA 複合体はリサイクリングエンドソームにおいてAQP2を効率的に活性化し尿量を調節する
- 2023/11 - Japan Medical Association Medical Research Encouragement Prize of The Japan Medical Association Elucidation of pathophysiology of chronic kidney disease using patient-derived organoids
- 2023/03 - Tokyo Medical Association 2022 Tokyo Medical Association Medical Research Award Encouragement Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/06 - Japanese Society of Nephrology Young Investigator Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/03 - Tokyo Medical and Dental University Medical Alumni Association The 35th Research Excellence Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/02 - Tokyo Medical and Dental University Medical Association 2021 Medical Association Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2018/05 - Brigham and Women's Hospital Cardio-Renal Research Award Proximal tubular uptake of free fatty acid (FFA) by Kidney Injury Molecule-1 (KIM-1) mediates tubulointerstitial disease in diabetic nephropathy (DN)
- 2018/01 - バゾプレシン研究会 第28回バゾプレシン研究会 研究奨励賞 家族歴のない成人多発性腎嚢胞患者における網羅的遺伝子解析を用いた遺伝子診断と臨床所見の検討
- 2017/01 - バゾプレシン研究会 第27回バゾプレシン研究会 研究奨励賞 高カリウムはカリシニューリンを活性化しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する
- 2016/10 - Japanese Society of Nephrology Award of Excellence, The 46th Eastern Regional Meeting of the Japanese Society of Nephrology
- 2015/01 - バゾプレシン研究会 第25回バゾプレシン研究会 研究奨励賞 AngiotensinIIによる血管平滑筋収縮の新しい機序 -KLHL2-WNK3-SPAK-NKCC1カスケード-
- 2014/07 - Japanese Society of Nephrology Award of Excellence, The 57th Annual Meeting of the Japanese Society of Nephrology
- 2014/03 - Tsuchiura Kyodo General Hospital 2013th Academic Encouragement Award of Internal Medicine
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Association Membership(s) (6):
The Molecular Biology Society of Japan
, AMERICAN SOCIETY OF NEPHROLOGY
, JAPANESE SOCIETY OF NEPHROLOGY
, THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, American Heart Association
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