Hayashi Hironori

Affiliation and department：
Job title： assistant professor
Other affiliations (1)：

National Center for Global Health and Medicine

Research field (4)： Molecular biology , Structural biochemistry , Bacteriology , Virology

Research theme for competitive and other funds (8)：

2023 - 2026 高活性触媒的標的RNA切断機能付与型人工核酸の構築と新興感染症等治療基盤の創製
2023 - 2026 Development of novel antibacterial agents using crystal structure-based drug screening
2023 - 2026 非天然型複合体を促進する化合物の合理的設計法開発
2019 - 2022 Development of therapeutics for intractable infections using diverse natural products combined with stress-inductive biosynthesis and chemical modification
2019 - 2021 Development of cross-virus drugs using norovirus as a model

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Papers (46)：

Hironori Hayashi, Erika Saijo, Kazushige Hirata, Shumei Murakami, Haruka Okuda, Eiichi N Kodama, Kazuya Hasegawa, Kazutaka Murayama. SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase. Archives of biochemistry and biophysics. 2024. 110160-110160
Shin-Ichiro Hattori, Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, et al. Structural and virologic mechanism of the emergence of resistance to Mpro inhibitors in SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 37. e2404175121
Hiroshi Yabu, Misako Suzuki, Kazushige Matsukawa, Ikuma Maeda, Sigeo Ihara, Koshiro Yaegashi, Kentaro Totsu, Hironori Hayashi, Eiichi Kodama. Janus-Type Immunofluorescent Probes and a Quantitative Immunoassay System. Langmuir : the ACS journal of surfaces and colloids. 2024
Kazushige Hirata, Aoi Takahara, Satoshi Suzuki, Shumei Murakami, Kumi Kawaji, Akie Nishiyama, Mina Sasano, Mariko Shoji-Ueno, Emiko Usui, Kazutaka Murayama, et al. Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors. iScience. 2024. 27. 2. 108961-108961
Kenichi Matsuda, Shinya Niikura, Rintaro Ichihara, Kei Fujita, Anna M Strasser, Rokusuke Yoshikawa, Jiro Yasuda, Yoshiki Hiramatsu, Hironori Hayashi, Eiichi N Kodama, et al. Synthesis and Cytotoxicity of Cyclic Octapeptide Surugamides with Varied N-Acyl Moieties. Chemical & pharmaceutical bulletin. 2024. 72. 9. 826-830

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MISC (33)：

篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, HAYDAR Bulut, et al. Development of small molecule inhibitors with potent antiviral activity targeting SARS-CoV-2 main protease. 日本薬学会年会要旨集(Web). 2024. 144th
鍬田伸好, 辻耕平, 林宏典, 石井貴大, 小早川拓也, 中野堅太, 服部真一朗, 岸本直樹, 高宗暢暁, 青木宏美, et al. 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発. 日本エイズ学会誌. 2023. 25. 4. 428-428
鍬田伸好, 辻耕平, 林宏典, 石井貴大, 小早川拓也, 中野堅太, 服部真一朗, 岸本直樹, 高宗暢暁, 青木宏美, et al. 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発. 日本エイズ学会誌. 2023. 25. 4. 428-428
鈴木聡志, 天野陽斗, 薄井友輔, 河治久実, 笹野美奈, 西山瑛絵, 平松佳樹, 橋本浩一, 村山和隆, 児玉栄一, et al. Development of novel protein-protein interaction inhibitors against respiratory syncytial virus. 日本小児科学会雑誌. 2023. 127. 2. 231-231
鈴木聡志, 黒田実央, 河治久実, 村山和隆, 林宏典, 大石真也, 児玉栄一. Blocking protein-protein interactions are applicable to development of novel antiviral agents for SARS-CoV-2. 日本小児科学会雑誌. 2023. 127. 2. 235-235

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Books (4)：

臨床と微生物
近代出版 2018
HIV感染症とAIDSの治療
株式会社メディカルレビュー社 2017
臨床と研究臨床と研究
大同学館出版 2012
Combinatorial Methods for Chemical and Biological Sensors
Supringer 2008 ISBN:9780387737126

Education (3)：

2010 - 2014 Kumamoto University Graduate School of Medical Sciences
2005 - 2010 京都大学大学院エネルギー科学研究科
2001 - 2005 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (1)：

博士 (医学) (熊本大学)

Work history (4)：

2020/10 - 現在東北大学災害科学国際研究所災害感染症学分野助教
2018/10 - 2021/09 Tohoku University Faculty of Medicine
2018/04 - 2018/09 東北大学病院検査部助教
2014/10 - 2018/03 国立国際医療研究センター難治性ウイルス感染症研究部研究員

Awards (5)：

2016 - 日本エイズ学会ECC山口メモリアルエイズ研究奨励賞
2016 - 第26回抗ウイルス療法学会学術集会塩田賞
2014/09 - 熊本大学学長賞
2009/04 - 日本学術振興会特別研究員
2008/03 - 日本化学会第88回春季年会学生講演賞

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