Research theme for competitive and other funds (15)：
2022 - 2025 エルゴチオネインによるアミロイドβ誘発神経毒性保護効果の分子機構解明
2019 - 2022 Elucidation of pharmacotherapeutic roles of xenobiotic uptake membrane transporters in epileptic seizures
2016 - 2019 Elucidation of intracellular mechanisms underlying neuronal maturation promoted by solute carrier OCTN1 and biomarker exploration in neuropsychiatric disorders
2015 - 2019 Investigation of disease biomarkers using metabolome analysis targeted to transporters
2015 - 2017 Mechanism of postprandial hyperglycemia due to transporter gene knockout and identification of endogenous substrates
2015 - 2017 Study on prostaglandin transporter as a novel target for anti-inflammatory drugs
2013 - 2016 Elucidation of neural control mechanisms by solute carrier OCTN1 and the application to treatment of depression
2013 - 2015 Transdermal drug delivery targeted to xenobiotics ABC transporters expressed in the skin
2012 - 2015 Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases
2011 - 2012 Development of triple-target antitumor drugs recognized by oligopeptide transporters
2010 - 2012 Modulation of proliferation and differentiation capacitiesby solute carrier transporters in neural progenitor cells
2008 - 2010 Research of transporter-adaptor network as target of drug effect and toxicity
2008 - 2009 Regulatory mechanisms of cell survival by glutamine transporter in the brain
2006 - 2007 NMDAレセプターチャネルのメンブラントラフィック機構
2003 - 2004 神経細胞成熟度と鉄動態感応性グルタミン酸シグナル入力の関連性に関する研究
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Papers (98)：
Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki, Yukio Kato. Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice. Current molecular pharmacology. 2021. 14. 2. 220-233
Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura, Yusuke Masuo, Tomoe Komori, Takahiro Ishimoto, Jun-ichi Matsuo, Yukio Kato. Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice. Neurochemical Research. 2020. 45. 11. 2664-2678
Yasufumi Takahashi, Yuanshu Zhou, Takafumi Miyamoto, Hiroki Higashi, Noritaka Nakamichi, Yuka Takeda, Yukio Kato, Yuri Korchev, Takeshi Fukuma. High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons. Analytical chemistry. 2020. 92. 2. 2159-2167
Hashimoto, N, Nakamichi, N, Nanmo, H, Kimura, K, Masuo, Y, Sakai, Y, Schinkel, A.H, Sato, S, Soga, T, Kato, Y. Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein. Pharm. Res. 2019. 36. 11. 158--
Al-Shammari AH, Masuo Y, Fujita KI, Yoshikawa Y, Nakamichi N, Kubota Y, Sasaki Y, Kato Y. Influx and Efflux Transporters Contribute to the Increased Dermal Exposure to Active Metabolite of Regorafenib After Repeated Oral Administration in Mice. Journal of pharmaceutical sciences. 2019. 108. 6. 2173-2179
Takahiro Ishimoto, Yukio Kato, Yusuke Masuo, Noritaka Nakamichi. Food-derived antidepressant-like compound ergothioneine promotes neuronal differentiation via activating mTORC1 and neurotrophic factor signaling in neural stem cells. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016. 19. 122-122
Noritaka Nakamichi, Yukio Kato, Yusuke Masuo, Misa Nishiyama. Attenuation of PTZ-induced epileptic seizure by deficiency in the gene encoding solute carrier OCTN1/SLC22A4. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016. 19. 268-268
Ehrhardt Carsten, Selo Mohammed Ali, Clerkin Caoimhe Geraldine, Talbot, Brian Noel, Walsh John Jarlath, Nakamichi Noritaka, Kato Yukio, Lewis Joshua B, Reynolds Paul R, et al. Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo. FASEB JOURNAL. 2016. 30
Takuya Shimizu, Yusuke Masuo, Noritaka Nakamichi, Yukio Kato. FUNCTIONAL EXPRESSION OF OCTN1/SLC22A4 IN INTESTINAL MACROPHAGES DURING GASTROINTESTINAL INFLAMMATION. DRUG METABOLISM REVIEWS. 2015. 47. 284-285
2018/04 - 現在 Takasaki University of Health and Welfare Faculty of Pharmacy
2009/07 - 2018/03 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy
2008/12 - 2009/06 Nagasaki University Graduate School of Biomedical Sciences
2008/04 - 2008/11 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy
2007/04 - 2008/03 Kanazawa University Graduate School of Natural Science and Technology
2006/04 - 2007/03 Kanazawa University Graduate School of Natural Science and Technology
2005/04 - 2006/03 Kanazawa University
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Committee career (8)：
2020 - 現在 Cells Editorial Board Member
2020 - 現在 Current Molecular Pharmacology Editorial Advisory Board Member
2018 - 現在 一般社団法人予防薬理学研究所 理事
2016 - 現在 Global Drugs and Therapeutics Associate Editor
2015 - 現在 日本神経化学会 評議員
2014 - 現在 Neurochemistry International Editorial Board Member
2010 - 現在 日本神経精神薬理学会 評議員
2008 - 現在 日本薬理学会 学術評議員
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Awards (2)：
2010/11 - 日本薬学会北陸支部学術奨励賞
2006/09 - 日本神経精神薬理学会学術賞
Association Membership(s) (7)：
Asian-Pacific Society for Neurochemistry
, International Society for Neurochemistry
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
, THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
, THE JAPANESE PHARMACOLOGICAL SOCIETY
