Rchr
J-GLOBAL ID：201801009667509730
Update date: Nov. 19, 2024
Shinomiya Nariyoshi
シノミヤ ナリヨシ | Shinomiya Nariyoshi
Affiliation and department：
Research field (1)：
Molecular biology
Research theme for competitive and other funds (16)：
- 2020 - 2024 Molecular and epidemiological research on gout and hyperuricemia from Japan: heading toward novel genome-personalized prevention and medicine
- 2020 - 2023 Interdisciplinary Research for Ethical, Legal, and Social Issues on Gene Drive
- 2020 - 2023 An association between serum uric acid and genetic polymorphism among pre- and post-menoposal women
- 2018 - 2023 Philosophising military research: from the perspective of "Dual-Use"
- 2020 - 2022 Development of diagnostic technique through a new, high-sensitivity gene-expression analysis: to promote secondary prevention against cancers which are difficult to detect early
- 2018 - 2021 Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophages
- 2018 - 2021 Development of new small molecules for Met stimulator and building up foundations of medical application
- 2017 - 2019 Genetic and epidemiological analysis of noise-induced hearing loss (NIHL) towards its tailor-made medicine and prevention
- 2015 - 2019 Research on Landscape
- 2015 - 2018 Development of new dual inhibitors for c-Met targeting both allosteric and catalytic sites
- 2013 - 2017 Investigation of pathophysiology of gout by molecular genetic epidemiological analysis and application to genome-tailored medicine
- 2014 - 2016 Immunological properties and functions of phagocytic B cells
- 2013 - 2015 Investigation of novel protective factors for Parkinson's disease through molecular genetic-epidemiological analysis of the gout gene
- 2011 - 2014 Development and biological evaluation of small molecule inhibitors for Met using a new strategy
- 2011 - 2012 Development of MR imaging technology and cell labeling contrast agents for tracking the biokinetics of dendritic cells.
- 2010 - 2012 Mechanical analyses and treatment of immunodeficiency following burn injury
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Papers (193)：
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Yusuke Kawamura, Akiyoshi Nakayama, Masahiro Nakatochi, Yuka Aoki, Yu Toyoda, Takahiro Nakamura, Seiko Shimizu, Keitaro Matsuo, Nariyoshi Shinomiya, Hirotaka Matsuo. Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level. Human cell. 2024. 38. 1. 15-15
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Tanya J Major, Riku Takei, Hirotaka Matsuo, Megan P Leask, Nicholas A Sumpter, Ruth K Topless, Yuya Shirai, Wei Wang, Murray J Cadzow, Amanda J Phipps-Green, et al. A genome-wide association analysis reveals new pathogenic pathways in gout. Nature genetics. 2024
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Yu Toyoda, Tappei Takada, Akiyoshi Nakayama, Nariyoshi Shinomiya, Hirotaka Matsuo. Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells. Human cell. 2024
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中山 昌喜, 白井 雄也, 河村 優輔, 豊田 優, 中杤 昌弘, 清水 聖子, 四ノ宮 成祥, 岡田 随象, 松尾 洋孝. コーヒーは尿酸値と独立して痛風リスクを減少させる 日欧の人種集団におけるメンデルランダム化解析より. Journal of Epidemiology. 2023. 33. Suppl.1. 86-86
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豊田 優, 河村 優輔, 中山 昌喜, 清水 聖子, 川口 真, 高田 雄三, 市田 公美, 四ノ宮 成祥, 松尾 洋孝, 高田 龍平, et al. OAT10は生理学的に重要な尿酸再吸収輸送体である. 日本痛風・尿酸核酸学会総会プログラム・抄録集. 2023. 56回. 68-68
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MISC (461)：
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中山 昌喜, 中杤 昌弘, 河村 優輔, 清水 聖子, 東野 俊英, 清水 徹, 大山 恵子, 大山 博司, 長瀬 満夫, 日高 雄二, et al. ゲノムワイド関連解析による病型特異的な痛風関連遺伝子の同定と日本人の適応進化. 痛風と尿酸・核酸. 2021. 45. 2. 196-196
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赤司 藍理, 中山 昌喜, 東野 俊英, 清水 聖子, 河村 優輔, 川口 真, 高尾 幹也, 高田 龍平, 市田 公美, 大山 博司, et al. LDL receptor gene familyのひとつであるLRP2遺伝子の一塩基多型rs2544390は痛風発症と関連する 日本人男性におけるメタ解析. 痛風と尿酸・核酸. 2020. 44. 1. 87-87
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河村 優輔, 東野 俊英, 清水 聖子, 中山 昌喜, 大山 恵子, 大山 博司, 清水 徹, 川口 真, 高尾 幹也, 市田 公美, et al. URAT2/OAT10遺伝子の機能低下型ミスセンスSNPは血清尿酸値と痛風のリスクを共に低下させる. 痛風と尿酸・核酸. 2020. 44. 1. 89-89
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河村 優輔, 松尾 洋孝, 清水 聖子, 中山 昌喜, 四ノ宮 成祥. 【症例で学ぶ!腎泌尿器診療ガイドラインの使い方】(第8章)代謝性疾患 腎性低尿酸血症 モデル症例とピットフォール. 腎と透析. 2020. 88. 増刊. 377-383
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中山 昌喜, 松尾 洋孝, 四ノ宮 成祥. 【腎臓と運動・スポーツ】運動後急性腎不全 腎性低尿酸血症による腎障害. 腎と透析. 2020. 88. 4. 533-537
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