HARA Kodai

ハラコウダイ | HARA Kodai

Affiliation and department：
Job title： Associate Professor

Research field (2)： Structural biochemistry , Pharmaceuticals - analytical and physicochemistry

Research keywords (5)： Structural Biology , Xray Crystallography , Chromosome , DNA Repair , Natural Products Chemistry

Research theme for competitive and other funds (11)：

2024 - 2027 ミスマッチ修復を促進するクロマチンリモデラーの構造生物学的解明
2023 - 2026 肝星細胞における液-液相分離を標的としたNASH進行スイッチ制御の確立
2023 - 2026 Structural basis for stimulation of DNA damage checkpoint by 9-1-1 interacting protein RHINO
2014 - 2025 静岡県立大学教員特別研究推進費
2020 - 2024 脊椎動物の染色体凝縮を担うコンデンシンの構造基盤と動的挙動の解明

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Papers (38)：

Takuma Kobayashi, Shiori Oishi, Misaki Matsui, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe, Yasukiyo Yoshioka, Noriyuki Miyoshi. Tyrosine phenol-lyase inhibitor quercetin reduces fecal phenol levels in mice. PNAS Nexus. 2024. 3. pgae265
Nakahara M, Watanabe S, Sato M, Okumura H, Kawatani M, Osada H, Hara K, Hashimoto H, Watanabe K. Structural and functional analyses of inhibition of human dihydroorotate dehydrogenase by antiviral furocoumavirin. Biochemistry. 2024. 63. 10. 1241-1245
Matsushita T, Kishimoto S, Hara K, Hashimoto H, Yamaguchi H, Saito Y, Watanabe K. Functional enhancement of flavin-containing monooxygenase through machine learning methodology. ACS Catalysis. 2024. 14. 9. 6945-6951
Hara K, Tatsukawa K, Nagata K, Iida N, Hishiki A, Ohashi E, Hashimoto H. Structural basis for intra- and inter-molecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. The Journal of biological chemistry. 2024. 300. 3. 105751
Sato M, Sakano S, Nakahara M, Tamura Y, Hara K, Hashimoto H, Tang Y, Watanabe K. Uncommon arrangement of self-resistance allows biosynthesis of de novo purine biosynthesis inhibitor that acts as an immunosuppressor. Journal of the American Chemical Society. 2023. 145. 49. 26883-26889

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MISC (14)：

原幸大, 橋本博. DNA損傷応答クランプの最新の構造生物学. 放射線生物研究. 2024. in press
原幸大, 橋本博. ゲノム維持に関わるタンパク質の構造生物学. Photon Factory Activity Report 2023 Users' Report. 2024. 41
原幸大, 橋本博. 染色体構築とゲノム維持の分子メカニズム解明に向けた構造研究. Photon Factory Activity Report 2022 Users' Report. 2023. 40
原幸大, 橋本博. 3R&3Cを担うタンパク質のX線結晶構造解析. Photon Factory Activity Report 2020 Users' Report. 2021. 38
原幸大, 橋本博. コンデンシンIにおけるHEAT-kleisin相互作用の構造生物学的研究. 生化学. 2020. 92. 6. 801-805

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Lectures and oral presentations (185)：

9-1-1の機能制御に関わるRAD9サブユニットを介した相互作用の構造基盤
(令和6年(2024年)度日本結晶学会 2024)
チェックポイントクランプ9-1-1のRAD9サブユニットにおける分子内および活性化因子RHINOとの分子間相互作用の構造基盤
(第97回日本生化学会 2024)
The polyphenols metabolite, 3,5-dihydroxybenzoic acid, inhibits tyrosine phenol-lyase, decreasing the fecal phenol levels in mice
(11th International Conference on Polyphenols and Health 2024)
没食子酸誘導体によるtyrosine phenol-lyase阻害機構の解明
(日本農芸化学会中部支部第199回例会 2024)
染色体凝縮を担うコンデンシン制御サブユニットの構造生物学
(第6回静岡県大学研究連携シンポジウム/第18回超領域研究会 2024)

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Education (4)：

2007 - 2010 Yokohama City University International Graduate School of Arts and Sciences Doctoral Course
2005 - 2007 Yokohama City University International Graduate School of Arts and Sciences Master's Course
2001 - 2005 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science
1997 - 2000 Chiba Higashi High School

Professional career (1)：

Doctor of Science (Yokohama City University)

Work history (5)：

2021/10 - 現在 University of Shizuoka School of Pharmaceutical Sciences Associate Professor
2018/10 - 2021/09 University of Shizuoka School of Pharmaceutical Sciences Lecturer
2014/01 - 2018/09 University of Shizuoka School of Pharmaceutical Sciences Assistant Professor
2011/07 - 2013/12 University of Texas Southwestern Medical Center Postdoctoral Researcher
2010/04 - 2011/06 University of Minnesota Postdoctoral Researcher

Committee career (13)：

2023/10 - 現在 University of Shizuoka Editorial Board Member, Journal of Lifelong Well-being Sciences
2024/03 - 日本薬学会第144年会(横浜) ポスター発表学生優秀発表賞審査員
2023/06 - 第27回 DNA複製・組換え・修復ワークショップ座長
2019/04 - 2021/03 The Pharmaceutical Society of Japan Editorial Board Member, Farumashia
2021/03 - 日本薬学会第141年会(広島) ポスター発表学生優秀発表賞審査員

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Awards (1)：

2018/06 - Award for encouragement of research in the Tokai branch of pharmaceutical society of Japan

Association Membership(s) (4)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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