Rchr
J-GLOBAL ID：201801009825388155   Update date: Sep. 25, 2024

HARA Kodai

ハラ コウダイ | HARA Kodai
Affiliation and department：
University of Shizuoka School of Pharmaceutical Sciences / Graduate Division of Pharmaceutical Sciences

About University of Shizuoka School of Pharmaceutical Sciences / Graduate Division of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (2)： Structural biochemistry ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (5)： Structural Biology ,  Xray Crystallography ,  Chromosome ,  DNA Repair ,  Natural Products Chemistry
Research theme for competitive and other funds  (11)：
  • 2024 - 2027 ミスマッチ修復を促進するクロマチンリモデラーの構造生物学的解明
  • 2023 - 2026 肝星細胞における液-液相分離を標的としたNASH進行スイッチ制御の確立
  • 2023 - 2026 Structural basis for stimulation of DNA damage checkpoint by 9-1-1 interacting protein RHINO
  • 2014 - 2025 静岡県立大学教員特別研究推進費
  • 2020 - 2024 脊椎動物の染色体凝縮を担うコンデンシンの構造基盤と動的挙動の解明
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Papers (38)：
  • Kobayashi T, Ohishi S, Matsui M, Hara K, Hashimoto H, Watanabe K, Yoshioka Y, Miyoshi N. Tyrosine phenol-lyase inhibitor quercetin reduces fecal phenol levels in mice. PNAS Nexus. 2024. 3. pgae265
  • Nakahara M, Watanabe S, Sato M, Okumura H, Kawatani M, Osada H, Hara K, Hashimoto H, Watanabe K. Structural and functional analyses of inhibition of human dihydroorotate dehydrogenase by antiviral furocoumavirin. Biochemistry. 2024. 63. 10. 1241-1245
  • Matsushita T, Kishimoto S, Hara K, Hashimoto H, Yamaguchi H, Saito Y, Watanabe K. Functional enhancement of flavin-containing monooxygenase through machine learning methodology. ACS Catalysis. 2024. 14. 9. 6945-6951
  • Hara K, Tatsukawa K, Nagata K, Iida N, Hishiki A, Ohashi E, Hashimoto H. Structural basis for intra- and inter-molecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. The Journal of biological chemistry. 2024. 300. 3. 105751
  • Sato M, Sakano S, Nakahara M, Tamura Y, Hara K, Hashimoto H, Tang Y, Watanabe K. Uncommon arrangement of self-resistance allows biosynthesis of de novo purine biosynthesis inhibitor that acts as an immunosuppressor. Journal of the American Chemical Society. 2023. 145. 49. 26883-26889
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MISC (13)：
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Lectures and oral presentations  (181)：
  • 染色体凝縮を担うコンデンシン制御サブユニットの構造生物学
    (第6回静岡県大学研究連携シンポジウム/第18回超領域研究会 2024)
  • Tyrosine phenol-lyase阻害剤3,5-dihydroxybenzoic acid経口摂取はマウス糞便フェノール量を減少させる
    (日本農芸化学会2024年度大会 2024)
  • テンプレートスイッチを促進するSHPRHのペプチドとPCNAの結晶学的研究
    (日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2023 2023)
  • 染色体構築に必須のコヒーシン制御サブユニットの調製と結晶化
    (日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2023 2023)
  • DNA損傷チェックポイントを制御する9-1-1の分子内相互作用と活性化因子RHINOとの相互作用解析
    (日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2023 2023)
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Education (4)：
  • 2007 - 2010 Yokohama City University International Graduate School of Arts and Sciences Doctoral Course
  • 2005 - 2007 Yokohama City University International Graduate School of Arts and Sciences Master's Course
  • 2001 - 2005 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science
  • 1997 - 2000 Chiba Higashi High School
Professional career (1)：
  • Doctor of Science (Yokohama City University)
Work history (5)：
  • 2021/10 - 現在 University of Shizuoka School of Pharmaceutical Sciences Associate Professor
  • 2018/10 - 2021/09 University of Shizuoka School of Pharmaceutical Sciences Lecturer
  • 2014/01 - 2018/09 University of Shizuoka School of Pharmaceutical Sciences Assistant Professor
  • 2011/07 - 2013/12 University of Texas Southwestern Medical Center Postdoctoral Researcher
  • 2010/04 - 2011/06 University of Minnesota Postdoctoral Researcher
Committee career (13)：
  • 2023/10 - 現在 University of Shizuoka Editorial Board Member, Journal of Lifelong Well-being Sciences
  • 2024/03 - 日本薬学会第144年会(横浜) ポスター発表学生優秀発表賞審査員
  • 2023/06 - 第27回 DNA複製・組換え・修復ワークショップ 座長
  • 2019/04 - 2021/03 The Pharmaceutical Society of Japan Editorial Board Member, Farumashia
  • 2021/03 - 日本薬学会第141年会(広島) ポスター発表学生優秀発表賞審査員
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Awards (1)：
  • 2018/06 - Award for encouragement of research in the Tokai branch of pharmaceutical society of Japan
Association Membership(s) (4)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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