Enomoto Mitsuhiro

エノモトミツヒロ | Enomoto Mitsuhiro

Affiliation and department：
Job title： Visiting Lecturer

Research field (1)： Orthopedics

Research theme for competitive and other funds (11)：

2016 - 2018 生体骨を模した新しい複層型人工骨の開発とdrug delivery
2016 - 2018 末梢神経損傷に応答する疼痛慢性化分子の探索と治療開発
2015 - 2017 高圧・高酸素による軟部組織外傷の治癒促進と作用機序の解明
2014 - 2016 神経筋接合部を標的にした末梢神経再生
2012 - 2014 骨格筋損傷に対する高気圧酸素治療の作用機序の解明

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Papers (59)：

Naoki Yamamoto, Takuya Oyaizu, Kazuyoshi Yagishita, Mitsuhiro Enomoto, Masaki Horie, Atsushi Okawa. Multiple and early hyperbaric oxygen treatments enhance muscle healing after muscle contusion injury: a pilot study. Undersea Hyperb Med. 2021. 48. 3. 227-238
Hiroyuki Yokoyama, Takashi Hirai, Tetsuya Nagata, Mitsuhiro Enomoto, Hidetoshi Kaburagi, Li Leiyo, Takayuki Motoyoshi, Toshitaka Yoshii, Atsushi Okawa, Takanori Yokota. DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models. J Pain Res. 2020. 13. 3031-3043
Yamamoto Naoki, Oyaizu Takuya, Yagishita Kazuyoshi, Enomoto Mitsuhiro, Horie Masaki, Ohara Toshiyuki, Shioda Mikio, Takada Ryohei, Okawa Atsushi. Hyperbaric Oxygen Therapy Promotes Muscle Recovery After Contusion Injury Via Angiogenesis By Reactive Nitrogen Species. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 2020. 52. 17. 929-929
Kyohei Sakaki, Yuko Hoshino, Shigenori Kawabata, Yoshiaki Adachi, Taishi Watanabe, Kensuke Sekihara, Senichi Ishii, Masaki Tomori, Shoji Tomizawa, Mitsuhiro Enomoto, et al. Evaluation of neural activity by magnetospinography with 3D sensors. Clin Neurophysiol. 2020. 131. 6. 1252-1266
Leyang Li, Hiroyuki Yokoyama, Hidetoshi Kaburagi, Takashi Hirai, Kunikazu Tsuji, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Atsushi Okawa. Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair. Neural Regen Res. 2020. 15. 4. 731-738

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MISC (12)：

平井高志, 榎本光弘, 鏑木秀俊, 横山裕之, 永田哲也, 横田隆徳, 大川淳. 【腰痛治療の革新-慢性腰痛・神経障害性疼痛に対する治療のbreakthrough】神経障害性疼痛のメカニズム探索と分子標的による新規治療戦略. Journal of Spine Research. 2018. 9. 6. 1022-1030
Mitsuhiro Enomoto. Therapeutic effects of neurotrophic factors in experimental spinal cord injury models. Journal of Neurorestoratology. 2016. 4. 15-22
榎本光裕, 大川淳. 【成人脊柱変形へのアプローチ】腰椎後彎変形患者の腰背筋評価. 臨床整形外科. 2015. 50. 11. 1053-1058
spinal cord and peripheral nerve disorders. 2015. 50. 2. 101-105
榎本光裕, 大川淳. 【腰椎変性後側彎症-病態から治療まで-】脊柱後彎変形に伴う腰背筋筋活動の変化. Orthopaedics. 2015. 28. 2. 15-21

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Books (3)：

Neuroprotection and Regeneration of the Spinal Cord
Springer 2014
Spinal Cord Injuries: Causes, Risk Factors and Management
Nova Science Publishers, Inc 2012
復帰をめざすスポーツ整形外科
Medical View社 2011

Lectures and oral presentations (57)：

骨格筋圧挫損傷急性期において高気圧高酸素環境は低酸素誘導因子の増加を介して筋新生に至る過程を促進する
(第35回日本整形外科学会基礎学術集会 2020)
DNAマイクロアレイを用いたマウス腰部後根神経節における神経障害性疼痛関連遺伝子の調査
(第35回日本整形外科学会基礎学術集会 2020)
骨格筋圧挫損傷急性期において早期の高気圧高酸素治療は筋再生促進に有用である
(第93回日本整形外科学会学術総会 2020)
Hyperbaric oxygen therapy promotes muscle regeneration via angiogenesis by reactive nitrogen species in muscle contusion injury of rat.
(The 4th conference of Asia-pasific Undersea and Hyperbaric Medical Society 2019)
骨格筋圧挫損傷急性期において高気圧高酸素環境は筋内血管新生を促進する
(第34回日本整形外科学会基礎学術集会 2019)

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Education (2)：

- 2003 Tokyo Medical and Dental University Graduate School, Division of Medical Sciences
- 1995 Fukushima Medical University Faculty of Medicine

Work history (9)：

2020/05/01 - 現在 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery Visiting Lecturer
2019/05/01 - 現在 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery Visiting Lecturer
2014/10/01 - 現在 Tokyo Medical and Dental University Sports Science Organization Clinical Center for Sports Medicine and Sports Dentistry Junior Associate Professor
2019/05/01 - 2020/03/31 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery Visiting Lecturer
2018/05/01 - 2019/04/30 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Sensory, Orthopedic, and Dematologic Medicine Orthopaedic Surgery Visiting Lecturer

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Committee career (1)：

2013/11 - 現在日本高気圧環境・潜水医学会幹事

Awards (2)：

2012 - 中冨健康科学振興財団・研究助成金痛み受容体を標的にした骨性疼痛の制御
2009 - 整形災害外科学研究助成財団エーザイ奨励賞 RNA干渉を用いた脊髄・末梢神経障害性疼痛に対する新規治療の開発

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