Atsushi Yamada

アツシヤマダ | Atsushi Yamada

Research field (1)： Oral medicine

Research keywords (1)：骨代謝

Research theme for competitive and other funds (33)：

2023 - 2026 ヒストンラクチル化による骨リモデリング制御機構の解明
2022 - 2025 Study on the role of sulfur respiration in homeostasis and disruption of the skeletal system under hypoxic conditions
2022 - 2024 Development of effective tissue regeneration method based on single cell genomics of neural crest derived cell
2020 - 2022 Construction of optimization system for hard tissue regenerating cells based on transcription network analysis
2019 - 2022 Regulation of bone remodeling by reactive sulfur species, the novel signal molecules

2019 - 2022 Nanomechanical characterization of enamel obtained from genetically modified mouse for conceptualizing advanced materials

2018 - 2022 Role of TPD52 as a suvival factor on OSCC cells in a hypoxic condition

2018 - 2021 Functions of Rho family proteins on hard tissue formation

2018 - 2020 Identification of specific cell surface antigens for separation of neural crest derived cells and its application to bone regenerative medicine

2017 - 2020 Effects of autophagy caused by osteoarthritis

2016 - 2019 Identification of novel specific makers of neural crest-derived cells in adult and their application to bone regenerative medicine

2015 - 2019 Mechanisms of Rho family proteins during cartolage and bone formation

2015 - 2018 On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP

2015 - 2018 adaptive bone remodeling on micro-structurally optimized titanium implant

2014 - 2018 Identification of osteoclast precursors that induce inflammatory bone destruction

2014 - 2016 Analysis of mechanism of osteoblastic ossification on anodically oxidized titanium plates

2012 - 2016 Identification of the novel factors on the modulation of osteoclastogenesis

2012 - 2015 Antibacterial and osteogenic properties on hydrophilic-modified hydroxyapatite coating on titanium

2012 - 2015 Mechanisms of Rac1 and Cdc42, Rho small GTPases, in bone and cartilage formation

2012 - 2015 Antioxidant and osteogenic properties on a modified titanium implant

2011 - 2013 Regulation of differentiation of hard-tissue-constituting cells by pH regulating proteins. Clarification of the mechanism and its application for regenerative medicine.

2011 - 2012 Expression and function in bone formation of extracellular matrix protein POEM

2010 - 2011 Functions of Cdc42 during skeletal development

2010 - 2011 Functions of Rac1 during bone and cartilage formation

2009 - 2011 Establishment of tooth regeneration using spheroid culture of neural crest-derived cells in bone marrow

2009 - 2010 Clarification of the function of extracellular matrix protein POEM in the osteogenesis

2008 - 2010 Functional analysis of the transcription factor IRF-8 in physiological bone remodeling and inflammatory bone destruction

2008 - 2010 Identification of regulatory molecules for osteogenic activity of BMP.

2008 - 2009 Roles of Rac1 during limb development

2006 - 2007 Study on the roles of dendritic cells in inflammatory bone destruction

2006 - 2007 The analysis of epigenetic regulation of osteoblastogenesis induced by BMP-2

2006 - 2007 Functional analysis of nitric oxide metabolites in hard tissues

2006 - 2007 IL-4およびIL-13による破骨細胞分化抑制機構の解明

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Papers (70)：

Shinnosuke Ono, Atsushi Yamada, Junichi Tanaka, Akane Yukimori, Kiyohito Sasa, Kenji Mishima, Takahiro Funatsu, Ryutaro Kamijo. BMP-2-mediated signaling suppresses salivary gland development. Biochemical and biophysical research communications. 2023. 681. 1-6
Kei Nagasaki, Atsushi Yamada, Kiyohito Sasa, Ryutaro Kamijo. Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2. FEBS open bio. 2023
Erika Minami, Kiyohito Sasa, Atsushi Yamada, Ryota Kawai, Hiroshi Yoshida, Haruhisa Nakano, Koutaro Maki, Ryutaro Kamijo. Lactate-induced histone lactylation by p300 promotes osteoblast differentiation. PloS one. 2023. 18. 12. e0293676
Motohiro Tanaka, Yoichi Miyamoto, Kiyohito Sasa, Kentaro Yoshimura, Atsushi Yamada, Tatsuo Shirota, Ryutaro Kamijo. Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß. In Vitro Cellular & Developmental Biology - Animal. 2022
Kaori Ikezaki-Amada, Yoichi Miyamoto, Kiyohito Sasa, Atsushi Yamada, Mitsuhiro Kinoshita, Kentaro Yoshimura, Ryota Kawai, Fumiko Yano, Tatsuo Shirota, Ryutaro Kamijo. Extracellular acidification augments sclerostin and osteoprotegerin production by Ocy454 mouse osteocytes. Biochemical and Biophysical Research Communications. 2022. 597. 44-51

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MISC (62)：

頌彦玲子, 頌彦玲子, 笹清人, 山田篤, 宮本洋一, 吉村健太郎, 上條竜太郎. ゾレドロン酸による末梢血単球の破骨細胞分化抑制. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2020. 38th
瀧本玲子, 田中元博, 田中元博, 山田篤, 宮本洋一, 笹清人, 須澤徹夫, 吉村健太郎, 高見正道, 上條竜太郎. Zoledronate suppresses the differentiation of osteoclasts from human monocytes. Journal of Oral Biosciences Supplement (Web). 2020. 2020
瀧本玲子, 田中元博, 笹清人, 山田篤, 宮本洋一, 須澤徹夫, 吉村健太郎, 上條竜太郎. ゾレドロン酸はIRF8の発現誘導を介して末梢血単球の破骨細胞分化を抑制する. Journal of Oral Biosciences Supplement. 2019. 2019. 200-200
瀧本玲子, 宮本洋一, 山田篤, 須澤徹夫, 笹清人, 上條竜太郎, 代田達夫. ビスホスホネートのヒト末梢血単核細胞に対する作用の解析. 昭和学士会雑誌. 2019. 79. 2. 226-226
Manome Y, Suzuki D, Nishida R, Yamada A, Miyamoto Y, Funatsu T, Kamijo R. Immunotherapy for malignant tumors with focus on toll-like receptors. Oral Science International. 2019. 16. 3-7

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Education (3)：

1997 - 2001 東京大学大学院農学生命科学研究科獣医学専攻
1995 - 1997 東京工業大学大学院生命理工学研究科バイオテクノロジー専攻
1991 - 1995 東京工業大学生命理工学部生物工学科

Work history (4)：

2022/04 - 現在昭和大学歯学部口腔生化学講座准教授
2006/10 - 2022/03 昭和大学歯学部口腔生化学講座講師
2005/03 - 2006/09 昭和大学歯学部口腔生化学教室助手
2001/06 - 2005/02 米国国立がん研究所ポストドクター

Awards (1)：

2022/12 - 日本口腔組織培養学会学術奨励賞

Association Membership(s) (3)：

日本口腔組織培養学会 , 歯科基礎医学会 , 日本骨代謝学会

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