Hara Hiromitsu

ハラヒロミツ | Hara Hiromitsu

Affiliation and department：
Job title： Professor

Research field (1)： Immunology

Research keywords (10)： NF-kappaB , パターン認識受容体 , 抗原受容体 , Trem2 , card11 , アレルギー性接触皮膚炎 , 抗酸菌 , 結核 , card9 , ITAM

Research theme for competitive and other funds (27)：

2023 - 2026 TREM2を介したマクロファージの許容的分化と機能調節機構の解明
2021 - 2024 眼球内細胞学の確立:基礎から臨床までのシームレスな研究
2021 - 2024 CARD11遺伝子変異に基づくアトピー性皮膚炎の病態・臨床像の解明
2020 - 2023 抗酸菌病原性脂質の宿主認識と免疫制御機構の解明
2018 - 2021 Advanced research of vitreology

2017 - 2020 Targeting chronic active TCR pathway for developing new treatment for patients with ATL

2017 - 2020 Maternal DNA in the peripheral blood of patients with biliary atresia affect the prognosis

2017 - 2019 Research on the development of new sensitizing compound test method using myeloid ITAM-coupled receptors

2017 - 2019 Elucidation of the pathology of maxillofacial analgesia targeting the nerve-immune system of trigeminal ganglion and development of therapeutic method

2016 - 2019 Elucidation of glycosylation-dependent influenza virus recognition mechanism by novel innate immune receptor

2015 - 2018 Roles of receptors for damage-associated molecular patterns on neuropathic pain

2015 - 2018 Study of comprihensive vitreology

2015 - 2018 Regulation of innate immune response to mycobacteria through the recognition of immunoregulating cell wall lipids by ITAM-coupled receptors

2015 - 2018 Development of new mouse model of granulomatosis with polyangitis

2015 - 2017 Screening for innate immune receptors recognizing allergic compounds

2014 - 2017 Discovery of cytokine contributing to physiological sensory sensitivity adjustment and elucidation of controlling mechanism of pain

2013 - 2016 Analyses of the roles of CARD9-dependent innate immunity against protozoa infection

2012 - 2015 Roles of a newly identified pattern-recognition receptor family which activate innate immunity in development of neuropathic pain.

2012 - 2015 Role for novel innate immune receptors for pulmonary pathogens

2012 - 2014 アレルギー性接触皮膚炎感作に必要な非感染性自然免疫活性化経路

2011 - 2014 Investigation of the subretinal fibrosis due to vitreo-retinal diseases to develop new therapeutic strategies.

2010 - 2012 Studies of the immune regulation by IL-12-related immunosuppresive cytokines and their therapeutic application

2010 - 2011 ITAM受容体-CARD9経路による自己免疫病の発症・増悪機構の解明

2009 - 2011 Regulation of CARMA1 signaling and its role in immune homeostasis

2008 - 2009 ITAM受容体-CARD9シグナルの自己免疫病における役割

2007 - 2008 Research for signaling mechanisms and physiological roles of ITAM-coupling receptors

2005 - 2006 Carmalにより制御されるシグナル伝達分子の探索及びシグナル伝達機構の解析

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Papers (94)：

Hideo Mitsuyama, Ei'ichi Iizasa, Akiko Kukita, Shuji Toda, Hiroki Yoshida, Hiromasa Inoue, Hiromitsu Hara. Deletion of Card9 eliminates the detrimental facets of mycobacterial adjuvants. Heliyon. 2024
Sanjaadorj Tsogtsaikhan, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Daisuke Kimura, Mana Miyakoda, Masahiro Yamamoto, Hiromitsu Hara, Hiroki Yoshida, Katsuyuki Yui. Regulation of memory CD4+ T cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection. International immunology. 2024
Anna Miyahara, Aya Umeki, Ko Sato, Toshiki Nomura, Hideki Yamamoto, Tomomitsu Miyasaka, Daiki Tanno, Ikumi Matsumoto, Tong Zong, Takafumi Kagesawa, et al. Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs. Infection and immunity. 2024. e0002424
Shinyo Ishi, Emi Kanno, Hiromasa Tanno, Shiho Kurosaka, Miki Shoji, Toshiro Imai, Kenji Yamaguchi, Kanna Kotsugai, Momoko Niiyama, Haruko Kurachi, et al. Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling. Scientific reports. 2023. 13. 1. 15917-15917
後藤哲哉, 倉本恵梨子, 北脇綾乃, 河野博史, 松本信英, 原博満, 八木孝和, 大八木保政, 岩井治樹, 山中淳之. アルツハイマー病モデルマウスを使った口腔フレイル解析システムの開発. 老年精神医学雑誌. 2022. 33. 増刊II. 256-256

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MISC (90)：

原博満, 豊永憲司, 西城忍. Studies on the role of the ITAM-coupled receptor Trem2 in anti-fungal defense. 千葉大学真菌医学研究センター報告. 2020. 23
木村大輔, 木村大輔, 都田真奈, 中前早百合, SUKHBAATAR Odsuren, BAYARSAIKHAN Ganchimeg, 木村一美, FERNANDEZ-RUIZ Daniel, HEATH William, 原博満, et al. マラリア原虫治癒後における記憶CD4⁺T細胞の消失はIL-27依存的である. 日本寄生虫学会大会プログラム・抄録集. 2019. 88th
原博満, 豊永憲司, 西城忍. ITAM共役受容体Trem2のカンジダ感染防御における役割の解明. 千葉大学真菌医学研究センター報告. 2019. 22
飯笹英一, 三山英夫, 豊永憲司, 原博満. ITAM-Card9経路のGM-CSF受容体シグナルへの関与. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2019. 84th
蓮井和久, 佐藤榮一, 宇都宮與, 木脇祐俊, 満田稔, 斉藤稔, 原博満, 久保田龍二, 出雲周二. HTLV-1関連細胞株と成人T細胞白血病ないしリンパ腫(ATL)に於けるサバイビンの抗原回復免疫組織化学. 日本組織細胞化学会総会・学術集会講演プログラム・予稿集. 2018. 59回. 62-62

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Patents (14)：

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Lectures and oral presentations (7)：

Immunoregulation of mycobacteria through the recognition of lipids by host ITAM-coupled receptors
(2022)
Mycobacteria evade host immunity via TREM2, a macrophage receptor for non-glycosylated mycolic acids
(2022)
ITAM共役型パターン認識受容体を介した抗酸菌免疫応答の制御
(第 39 回九州実験動物研究会総会特別講演 2021)
抗酸菌ミコール酸含有脂質に対するパターン認識と応答
(第31回日本生体防御学会学術総会シンポジウム「宿主と微生物の共生と排除」 2020)
ITAM共役受容体を介した抗酸菌に対する自然免疫応答の制御
(第52回日本小児呼吸器学会教育講演 2019)

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Professional career (1)：

博士(医学) (九州大学)

Association Membership(s) (5)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本インターフェロンサイトカイン学会 , 日本生体防御学会 , JAPANESE SOCIETY FOR BACTERIOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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