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J-GLOBAL ID：201801010322521328   Update date: Aug. 03, 2024

Niibe Kunimichi

ニイベ クニミチ | Niibe Kunimichi
Affiliation and department：
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About -


Research field  (2)： Prosthodontics ,  Regenerative dentistry and dental engineering
Research keywords  (6)： induced Pluripotent Stem Cells ,  Mesenchymal Stem Cells ,  Prosthodontics ,  Tooth Regeneration ,  Stem cell ,  Regenerative medicine
Research theme for competitive and other funds  (12)：
  • 2023 - 2026 iPS細胞由来歯原性上皮系細胞を応用した歯胚再生への挑戦
  • 2023 - 2026 成体幹細胞の神経堤形質を増強した歯胚再生技術の開発
  • 2021 - 2022 iPS細胞/ハイドロゲル複合体を用いた骨補填材の開発
  • 2019 - 2022 -
  • 2020 - 2022 iPS細胞を原材料とした骨形成誘導補填材の開発
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Papers (37)：
  • 尾崎 茜, 依田 信裕, 山内 健介, 新部 邦透, 森島 浩允, 庄原 健太, 小山 重人, 江草 宏. 大学病院歯科インプラントセンターにおける初診患者の実態調査. 日本口腔インプラント学会誌. 2023. 36. 特別号. P-2
  • Nattasit P, Niibe K, Yamada M, Ohori-Morita Y, Limraksasin P, Tiskratok W, Yamamoto M, Egusa H. Stiffness-Tunable Hydrogel-Sandwich Culture Modulates the YAP-Mediated Mechanoresponse in Induced-Pluripotent Stem Cell Embryoid Bodies and Augments Cardiomyocyte Differentiation. Macromolecular Bioscience. 2023. 2300021-2300021
  • Zhang M, Niibe K, Kondo T, Limraksasin P, Okawa H, Miao X, Kamano Y, Yamada M, Jiang X, Egusa H. Rapid and Efficient Generation of Cartilage Pellets from Mouse Induced Pluripotent Stem Cells by Transcriptional Activation of BMP-4 with Shaking Culture. J Tissue Eng. 2022. 13. 20417314221114616
  • Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa. Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via theBMP-Smad Signaling Axis. Front Bioeng Biotechnol. 2022. 10. 890882
  • Ohori-Morita Y, Niibe K, Limraksasin P, Nattasit P, Miao X, Yamada M, Mabuchi Y, Matsuzaki Y, Egusa H. Novel mesenchymal stem cell spheroids with enhanced stem cell characteristics and bone regeneration ability. Stem Cells Transl Med. 2022. 11. 4. 434-449
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MISC (11)：
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Patents (3)：
  • Method for maintaining undifferentiation potential of mesenchymal stem cell employing shaking suspension culture
  • 振盪浮遊培養を用いた間葉系幹細胞の未分化性維持方法
  • 分化細胞由来多能性幹細胞の樹立法
Books (2)：
  • iPS細胞の再生医療の実現へ向けた動向
    ニュー・サイエンス社 2011
  • 間葉系幹細胞を用いたiPS細胞の高品質化
    ニュー・サイエンス社 2011
Lectures and oral presentations  (57)：
  • 新規振盪培養法により作製したマウス骨髄由来神経堤様細胞塊の性状解析
    (第23回日本再生医療学会 2024)
  • Lyophilized bone graft material generated from iPSCs.
    (The 102nd general session of International Association for Dental Research 2024)
  • 歯科補綴領域における幹細胞研究の可能性 〜歯の再生を目指して〜
    (第65回歯科基礎医学会学術大会 2023)
  • 大学病院歯科インプラントセンターにおける初診患者の実態調査
    (第53回日本口腔インプラント学会 2023)
  • Challenges to tooth regeneration using adult bone marrow mesenchymal stem cell-spheroids.
    (The University of Queensland and Tohoku University: Bilateral Dentistry Research Symposium 2023)
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Education (2)：
  • 2007 - 2011 Keio University Graduate School of Medicine
  • 1999 - 2005 Showa University Dentistry
Professional career (1)：
  • 医学博士 (慶應義塾大学)
Work history (9)：
  • 2021/04 - 現在 Tohoku University Hospital Molecular and Regenerative Prosthodontics Associate Professor
  • 2020/04 - 現在 Keio University School of Medicine
  • 2019/04 - 現在 Mayo Clinic Orthopedic Surgery Research Collaborator
  • 2014/10 - 2021/03 Tohoku University Molecular &Regenerative Prosthodontics Assistant Professor
  • 2018/04 - 2019/03 Mayo Clinic Orthopedic Surgery Research Fellow
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Committee career (1)：
  • 2023/06 - 現在 Journal of Prosthodontic Research (JPR) Editorial Committee Coordinator
Awards (8)：
  • 2024/03 - International Association for Dental Research. Pre-prosthetic regenerative scientific award; 1st Prize Award. Lyophilized bone graft material generated from iPSCs.
  • 2022/12 - Tissue Engineering & Regenerative Medicine International Society Asia Pcific Golden award (Student paper competition) Application of Stiffness-Tunable Hydrogel-Sandwich Culture for Accelerated Cardiomyogenic Differentiation of Induced Pluripotent Stem Cell-Embryoid Bodies
  • 2022/11 - 日本バイオマテリアル学会 最優秀研究ポスター賞 Modulation of Early Differentiation of iPS Cell Embryoid Bodies Using Stiffness-Tunable Hydrogel-Sandwich Culture
  • 2021/07 - International Association for Dental Research. Arthur R. Frechette Award; 1st Prize Award. Stepwise Ameloblast Induction from Induced Pluripotent Stem Cells.
  • 2021/05 - Chulalongkorn-Tohoku Joint Symposium in Dental Science 2021. 3rd Prize Award. Role of Amelx activation in stepwise ameloblast induction from mouse induced pluripotent stem cells.
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Association Membership(s) (4)：
JAPANESE SOCIETY OF ORAL IMPLANTOLOGY ,  JAPANESE SOCIETY OF PERIODONTOLOGY ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  Japan Prosthodontic Society
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