Rchr
J-GLOBAL ID：201801010434644023   Update date: Jan. 30, 2024

Yamashita Takefumi

Yamashita Takefumi
Affiliation and department：
The University of Tokyo Research Center for Advanced Science and Technology

About The University of Tokyo Research Center for Advanced Science and Technology


Research field  (1)： Bio-, chemical, and soft-matter physics
Research theme for competitive and other funds  (8)：
  • 2021 - 2025 1細胞計測に基づく細胞モデルとそれに基づく形態形成の理論の開発
  • 2020 - 2023 Optimization of pretargeted alpha therapy for multiple types of cancer
  • 2018 - 2023 タンパク質界面の複雑ダイナミクスの解析:機械学習とMD計算に基づく新手法の開拓
  • 2016 - 2023 制御における動的な溶媒効果の理論的解明
  • 2015 - 2020 Development of Molecular Dynamics Classification Theories for Life Science and Drug Design
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Papers (45)：
  • Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein expression and purification. 2023. 106375-106375
  • Yuichiro Takamatsu, Takao Hamakubo, Takefumi Yamashita. Molecular Dynamics Simulation of the Antigen-Antibody Complex Formation Process between Hen Egg-White Lysozyme and HyHEL-10. Bulletin of the Chemical Society of Japan. 2022. 95. 11. 1611-1619
  • Yudai Kaneko, Kenzo Yamatsugu, Takefumi Yamashita, Kazuki Takahashi, Toshiya Tanaka, Sho Aki, Toshifumi Tatsumi, Takeshi Kawamura, Mai Miura, Masazumi Ishii, et al. Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment. Cancer Science. 2022. 113. 12. 4350-4362
  • Naoyuki Shoji, Kohei Sasaki, Akira Uedono, Yuichi Taniguchi, Keiichi Hayashi, Norie Matsubara, Tetsuya Kobayashi, Takefumi Yamashita. Effect of conversion on epoxy resin properties: Combined molecular dynamics simulation and experimental study. Polymer. 2022. 254. 125041-125041
  • Kenzo Yamatsugu, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Toshifumi Tatsumi, Yudai Kaneko, Takeshi Kawamura, Mai Miura, Masazumi Ishii, et al. Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system. Protein Expression and Purification. 2022. 192. 106043-106043
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MISC (8)：
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Lectures and oral presentations  (85)：
  • Molecular Dynamics Simulation for Biological and Material polymers
    (International Congress on Pure & Applied Chemistry (ICPAC) 2022 2022)
  • A molecular dynamics study on the antigen-antibody interface: Toward rational antibody drug design
    (2022)
  • Properties of the Protein-Protein Interface Revealed by Molecular dynamics Simulations
    (18th International Conference of Computational Methods in Sciences and Engineering (QS symposium of ICCMSE 2022) 2022)
  • MDシミュレーションで考える抗原-抗体界面における塩橋の役割:合理的な抗体設計に向けて
    (日本蛋白質科学会学会年会 ワークショップ:「富岳」時代の計算蛋白質科学 2022)
  • 結合自由エネルギーの定量的予測と分子設計のための構造モチーフ探索
    (CBI学会第432回講演会「結合自由エネルギー計算は創薬研究戦略を変えるか」 2022)
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Education (3)：
  • 1998 - 2004 Kyoto University Graduate School of Science
  • 1996 - 1998 Kyoto University Graduate School of Science
  • 1992 - 1996 Kyoto University Faculty of Science
Professional career (1)：
  • 博士(理学) (京都大学)
Work history (7)：
  • 2023/04 - 現在 Hoshi University
  • 2011/01 - 現在 The University of Tokyo Research Center for Advanced Science and Technology
  • 2010/04 - 2010/12 ユタ大学 化学科 G.A.Voth研究室 Postdoctoral Scholar
  • 2008/04 - 2010/03 ユタ大学 化学科 G.A.Voth研究室 Postdoctoral Research Fellow
  • 2007/04 - 2008/03 ユタ大学 化学科 G.A.Voth研究室 日本学術振興会特別研究員
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