Ohazama Atsushi

オオハザマアツシ | Ohazama Atsushi

Affiliation and department：
Job title：教授

Research field (1)： Developmental biology

Research theme for competitive and other funds (34)：

2023 - 2026 歯の形成におけるDNA損傷/修復のメカニズムの解明
2023 - 2025 Investigation for X-inactivation in palate formation
2021 - 2024 Study for investigating mechanisms of mandibular development
2021 - 2024 Study for investigating mechanisms of mesiodens formation
2021 - 2024 皮膚の付属器官発生における老化活性の機能解明

2020 - 2023 舌誘導メカニズムの解明

2020 - 2023 顎顔面の発生過程における一次繊毛の機能解明:シグナル経路のクロストークの観点から

2019 - 2023 A new function of Shh signaling to control epithelial actomyosin contractility during tooth morphogenesis

2019 - 2022 Elucidation of mechanism on congenital abnormality in the maxillofacial region focusing on DNA repair mechanism

2021 - 2022 代生歯堤の形成・維持メカニズムの解明

2018 - 2021 Trail toward development of new treatment for ameloblastoma by intentional cell differentiation

2018 - 2021 analysis of the comprehensive molecular mechanism of temporomandibular joint formation

2017 - 2020 Understanding of tooth morphogenesis by studying supernumerary teeth

2017 - 2020 The Mechanism of Palatal Shelve Induction

2017 - 2020 Study of the involvement of epigenetics in cleft palate

2016 - 2020 Analysis of cleft palate mechanism using p53 gene-deficient consomic mice

2016 - 2019 Elucidation of control mechanism on stem cell differentiation for tooth regeneration

2015 - 2019 Activation of hedgehog signal pathway induces peripheral nerve regeneration

2017 - 2019 分化機構解明による幹細胞の意図的誘導法の開発

2017 - 2019 「生体完結型再生療法」開発への挑戦

2016 - 2018 Elucidation of developmetal mechanism on vermillion by molecular analysis -exploratory study for regeneratuion of vermillion -

2016 - 2018 遺伝子改変マウスを用いた歯誘導メカニズムの網羅的解析

2015 - 2018 Analysis of the cleft lip/palate development mechanism using the p53 knockout mouse with Artificial insemination frozen embryos

2015 - 2017 Tissue engineering of Temporomandibular joint organoids

2014 - 2016 Reprogramming of palatal mucosa into tooth-forming epithelium

2014 - 2016 幹細胞の分化制御機構の解明の基盤研究〜NF-kBからの解析〜

2014 - 2015 歯の発生における時間軸変更への挑戦

2011 - 2014 Roles of new ion channel involved in the regeneration/development of the periodontal Ruffini endings

2004 - 2005 The mechanisms of NF-kB in ectodermal appendages

2004 - 2005 Determination of the specific phenotype markers of ex vivo expanded human peridontal ligament cells

2004 - 2005 A study of the role of chemokine in regulation of human osteoclast differentiation

1997 - 1998 歯根膜の組織特異性に関する基礎的研究

1996 - 1996 歯槽骨再生に及ぼす歯根膜の関与に関する基礎的研究

1995 - 1995 歯根膜細胞の有無が歯槽骨再生に及ぼす影響についての基礎的研究

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Papers (108)：

Maiko Kawasaki, Katsushige Kawasaki, Finsa Tisna Sari, Takehisa Kudo, Jun Nihara, Madoka Kitamura, Takahiro Nagai, Vanessa Utama, Yoko Ishida, Fumiya Meguro, et al. Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling. eLife. 2024. 13
Piranit Kantaputra, Teerada Daroontum, Kantapong Kitiyamas, Panat Piyakhunakorn, Katsushige Kawasaki, Achara Sathienkijkanchai, Pornswan Wasant, Nithiwat Vatanavicharn, Thippawan Yasanga, Massupa Kaewgahya, et al. Homozygosity for a Rare Plec Variant Suggests a Contributory Role in Congenital Insensitivity to Pain. International journal of molecular sciences. 2024. 25. 12
Cholaporn Ruangchan, Chumpol Ngamphiw, Annop Krasaesin, Narin Intarak, Sissades Tongsima, Massupa Kaewgahya, Katsushige Kawasaki, Phitsanu Mahawong, Kullaya Paripurana, Bussaneeya Sookawat, et al. Genetic Variants in KCTD1 Are Associated with Isolated Dental Anomalies. International journal of molecular sciences. 2024. 25. 10
P Kantaputra, A Butali, S Eliason, C Chalkley, S Nakornchai, C Bongkochwilawan, K Kawasaki, A Kumchiang, C Ngamphiw, S Tongsima, et al. CACNA1S mutation-associated dental anomalies: A calcium channelopathy. Oral diseases. 2024. 30. 3. 1350-1359
サリ・フィンサ, ヴァネッサ・ウタマ, 川崎勝盛, 川崎真依子, 丹原惇, 大澤知朗, 工藤武久, 北村円, 前田健康, 大峡淳. マイクロRNAは顎顔面形成において老化シグナルを抑制している. 新潟歯学会雑誌. 2024. 53. 2. 98-98

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MISC (6)：

目黒史也, 目黒史也, 目黒史也, 柿原嘉人, 川崎真依子, 川崎勝盛, 川崎勝盛, 丹原惇, 丹原惇, トゥラカナンスッパラック, et al. Reptinは胎仔上皮におけるDNA損傷応答を介して器官形成を制御する. 新潟歯学会雑誌. 2020. 50. 2
齋藤直朗, 泉健次, 秋葉陽介, 加藤寛子, 原夕子, 小島拓, 芳澤享子, 小林正治, 大峡淳, 前田健康. ラット間葉系細胞の多面的骨誘導能に対する低酸素処理の効果に関する検討. 新潟歯学会雑誌. 2015. 45. 2. 106-106
Roman H. Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gael Clement, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G. Maisey, et al. the buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling (vol 11, 27, 2013). BMC BIOLOGY. 2013. 11
P. T. Sharpe, K. E. Haworth, A. Ohazama. A dual role for IKK alpha tooth development. JOURNAL OF DENTAL RESEARCH. 2003. 82. B305-B305
OKUBO Keigo, KOBAYASHI Makoto, OHAZAMA Atsushi, TAKIGUCHI Takashi, OKAMATSU Yoshimasa, DEGUCHI Katsutoshi, HASEGAWA Kohji. Effects of Enamel Matrix Protein on Cell Growth and Osteoblastic Differentiation On Periodontal Ligament Cells. Journal of the Japanese Association of Periodontology. 2000. 42. 156-156

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Work history (4)：

2016 - 現在新潟大学歯学部教授
2013 - 2015 新潟大学歯学部准教授
2006 - 2013 King’s College London (UK) principal investigator (PI)
2005 - 2006 King’s College London (UK) Senior research fellow

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