Chiba Mirei

チバミレイ | Chiba Mirei

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： http://www.dent.tohoku.ac.jp/field/morphology/02/index.html

Research field (11)： Oral medicine , Oral medicine (pathology) , Molecular biology , Cell biology , Physiology , Pharmacology , Developmental dentistry , Biomaterials , Biomedical engineering , Regenerative dentistry and dental engineering , Surgical dentistry

Research keywords (19)： Orthodontics , Physiology , Tooth movement , Temporomandibular joint disorders , Mechanical stress , Biomechanics , Periodontal ligament cells , Osteoclasts , Osteoblasts , Chondrocytes , iPS cells , Vibration stimulation , 1,25(OH)2D3 , Retinoic acid , Estrogen , Bisphosphonate , Radioactive materials , Strontium , Cesium

Research theme for competitive and other funds (27)：

2024 - 2028 福島第一原発事故後の被災動物における歯を基準とした放射線量の臓器分布
2024 - 2028 Utilizing Bisphosphonates with Anti-inflammatory and Antioxidant Properties in Orthodontic Anchor Screw Applications
2024 - 2027 Deciphering Vibrational Stimulus Signaling for Activation of Periodontal Tissue Remodeling Mechanisms
2022 - 2026 顎矯正手術後の治癒過程における骨代謝活性の亢進現象の解明とその臨床応用
2023 - 2026 骨細胞アポトーシスに着目した矯正学的歯の移動に伴う機械刺激応答性骨吸収機序の解明

2022 - 2025 画像解析による福島第一原発事故後の環境試料中のストロンチウム90濃度測定法の開発

2021 - 2024 歯を用いた原発事故被災小児の被ばく線量評価

2019 - 2022 Elucidation of the mechanism by which periodontal tissue responds to vibrational signals and its application

2018 - 2021 Dose assessment of external radiation exposure in Fukushima children using decidous teeth.

2015 - 2019 Screening for individual internal exposure using teeth

2014 - 2019 Mechanism of response of periodontal tissue to vibrational stimulation: molecular basis and clinical application

2014 - 2017 Radionuclides in the teeth of animal abundant in evacuation zone of Fukushima-Daiichi Nuclear Power Plant accident.

2012 - 2017 Mechanism of mechanoreceptive nerve regeneration: development of novel artificial dental roots with a mechanosensor

2014 - 2016 Measurement of low-dose and long-time external exposure using human teeth.

2013 - 2014 Exposed radiation dose in teeth and bone of animal in the evacuation zone of the fukushima daiichi nuclear power plant

2010 - 2012 A novel bisphosphonate with potent anabolic action for periodontitis

2010 - 2012 Analysis of the cellular mechanism of biomechanical signaling regulating the periodontal tissue remodeling

2006 - 2007 Analysis and clinical application of bone formation mechanism in immediate loading implant using materials driven by magnetic field

2004 - 2007 Analysis of periodontal tissue remodeling mechanism induced by mechanical stress and the regulation by gene transfer

2000 - 2003 RESEARCH OF PERIODONTAL TISSUE REMODELING ACTIVATION INDUCED BY VIBRATION AND ITS CLINICAL APPLICATION

2000 - 2002 Research of Osteoclastogenesis in Priodontium induced by mechanical stress and its Clinical Application

2000 - 2001 Regulatory mechanism of MMPs expression in periodontal ligament cells induced by mechanical stress

1997 - 1998 破骨細胞の分化過程における接着分子の発現調節とシグナル伝達機構

1995 - 1997 Mechanical stress in periodontium ; Cellular and molecular biological study and Clinical implication

1996 - 1996 破骨細胞の分化過程における接着分子の発現調節機構に関する研究

1995 - 1995 破骨細胞の分化過程における接着分子の発現調節機構に関する研究

1994 - 1994 接着分子の発現調節による破骨細胞の分化過程の解析

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Papers (77)：

Y. Mitsuyasu, T. Oka, A. Takahashi, Y. Kino, K. Okutsu, T. Sekine, T. Yamashita, Y. Shimizu, M. Chiba, T. Suzuki, et al. External exposure dose estimation of wild Japanese macaques captured in Fukushima prefecture: decomposition of electron spin resonance spectrum. Radiation Protection Dosimetry. 2023. 199. 14. 1620-1625
Mirei Chiba. Clinical implications of the mechanisms of molecular and cellular responses of mechanical stress in periodontal ligament tissue. Tohoku University Dental Journal. 2023. 41/42. 8-12
Junji Sugawara, Hiroshi Nagasaka, Yoko Abe, Mirei Chiba, Tetsu Takahashi. Recent protocol of the sendai surgery-first (SSF) approach: Clinical and scientific perspectives. Seminars in Orthodontics. 2022. 28. 4. 258-288
Toshitaka Oka, Atsushi Takahashi, Kazuma Koarai, Yasushi Kino, Tsutomu Sekine, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, et al. Detection limit of electron spin resonance for Japanese deciduous tooth enamel and density separation method for enamel-dentine separation. Journal of Radiation Research. 2022
Kazuma Koarai, Makoto Matsueda, Jo Aoki, Kayo Yanagisawa, Motoki Terashima, Kenso Fujiwara, Yasushi Kino, Toshitaka Oka, Atsushi Takahashi, Toshihiko Suzuki, et al. Rapid analysis of Sr-90 in cattle bone and tooth samples by inductively coupled plasma mass spectrometry. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 2021. 36. 8. 1678-1682

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MISC (157)：

光安優典, 岡壽崇, 高橋温, 木野康志, 奥津賢一, 関根勉, 山下琢磨, 清水良央, 千葉美麗, 鈴木敏彦, et al. A study on accuracy of analysis of the radiation-induced component in the ESR spectra of teeth. KEK Proceedings (Web). 2022. 2022-2
光安優典, 岡壽崇, 高橋温, 小荒井一真, 木野康志, 奥津賢一, 関根勉, 山下琢磨, 清水良央, 千葉美麗, et al. Development of dose estimation method using wild animal teeth for low dose exposure. KEK Proceedings (Web). 2021. 2021-2
岡壽崇, 高橋温, 光安優典, 小荒井一真, 木野康志, 奥津賢一, 山下琢磨, 関根勉, 清水良央, 千葉美麗, et al. External exposure dose estimation using ESR dosimetry technique. 放射線化学討論会講演要旨集. 2021. 64th (CD-ROM)
小野拓実, 木野康志, 高橋温, 鈴木敏彦, 清水良央, 千葉美麗, 藤嶋洋平, Goh Valerie, 有吉健太郎, 中田章史, et al. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ福島県浪江町に生息する野生動物の臓器の放射性セシウム濃度測定と内部被ばく線量推定(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Radioactive cesium concentration measurements and internal exposure dose rates estimation for wild animals in Namie Town, Fukushima). 日本放射線影響学会大会講演要旨集. 2020. 63回. 39-39
高橋温, 小野拓実, 小荒井一真, 岡壽崇, 清水良央, 千葉美麗, 鈴木敏彦, 有吉健太郎, 葛西宏介, 中田章史, et al. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ歯は個体被ばく量を評価するうえで有用である(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Teeth can be a useful dosimetric tool for estimating internal radiation exposure in individuals). 日本放射線影響学会大会講演要旨集. 2020. 63回. 39-39

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Books (4)：

人体の力学 : 基礎から学ぶバイオメカニクス
コロナ社 2020 ISBN:9784339072464
メカニカルストレスによる歯周組織改造機構の解析と遺伝子導入による制御
[千葉美麗] 2008
歯根膜細胞への遺伝子導入によるアプローチ;歯の移動の臨床バイオメカニクス : 骨と歯根膜のダイナミズム(下野正基;前田健康;溝口到編)
医歯薬出版 2006 ISBN:4263442172
振動刺激による歯周組織改造の賦活化機構の解析と臨床応用
[千葉美麗] 2004

Education (2)：

1987 - 1991 Tohoku University Graduate School of Dentistry Ph.D. course Clinical(Orthodonrics)
1981 - 1987 Tohoku University Faculty of Dentistry 歯学科

Professional career (1)：

歯学博士

Work history (12)：

2013/04 - 現在 Tohoku University Senior Assistant Professor
2008/01 - 現在 Tohoku University Graduate School of Dentistry, Department of Disease Management Dentistry, Division of Oral Physiology Lecturer
2006/10 - 2008/01 Tohoku University Senior Assistant Professor
2006/04 - 2006/10 Tohoku University Hospital
2006/04 - 2006/10 Tohoku University Graduate School of Dentistry Senior Assistant Professor

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Awards (12)：

2022/02 - 第43回東北骨代謝・骨粗鬆症研究会基礎部門『優秀賞』進行性下顎頭吸収におけるエストロゲンの関与: エチニルエストラジオールが青年期雌性ラットの下顎頭と長管骨に及ぼす影響
2021/07 - 2021 IADR GORG The GC Pre-Doctoral Award (First Prize) Novel Bisphosphonate Decreases Osteoclastogenesis in the Condyle of Ovariectomized Rats
2021/03 - 第22回環境放射能研究会奨励賞野生動物の歯を用いた低線量被ばく推定法の開発
2020/11 - 第68回 JADR(国際歯科研究学会日本部会)学術大会 IADR Hatton Awards 2021 Finalist, Senior Basic Science Research Category 部門 Effects of Estrogen and Mechanical Stress on Rat Mandibular Condyle
2020/02 - 第41回東北骨代謝・骨粗鬆症研究会臨床部門『優秀演題賞』顎矯正手術後の治癒過程において骨代謝マーカーと循環骨芽細胞系 OCN+ 細胞発現率は経時的に推移するー歯の移動促進への応用の可能性ー

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