Rchr
J-GLOBAL ID:201801010786373607
Update date: Nov. 21, 2024
Yamagishi Makoto
ヤマギシ マコト | Yamagishi Makoto
Affiliation and department:
Homepage URL (1):
https://square.umin.ac.jp/yamagishi/
Research field (1):
Molecular biology
Research keywords (5):
血液悪性腫瘍
, HTLV-1
, ゲノム医学
, エピジェネティクス
, ウイルス学
Research theme for competitive and other funds (15):
- 2024 - 2027 がんエピゲノムの恒常性メカニズムの解明と持続的なエピゲノム治療法の確立
- 2024 - 2026 治療反応性に関わる遺伝子翻訳及び代謝活性の腫瘍内不均一性の全体像解明と創薬シーズ探索
- 2023 - 2026 ゲノム情報を基盤としたHTLV-1感染症の病態形成機序の解明及び発症リスク予知アルゴリズム開発に関する総合的研究
- 2022 - 2025 HAMのシングルセル遺伝子発現解析による疾患特異的な免疫異常発現機構の解明
- 2021 - 2024 ゲノム異常とエピゲノム異常によるATLの協奏的クローン進化メカニズムの解明
- 2020 - 2023 HTLV-1関連疾患の発症リスク、進展メカニズムに関するオミックス統合解析と発症予防に資する基盤的研究
- 2020 - 2023 レトロウイルス病原性と持続感染の根源となる不均一な潜伏集団を生み出す宿主エピゲノム特性の解明と治療薬開発
- 2019 - 2022 Analysis of genomic and epigenomic regulatory mechanisms that determine abnormal characteristics of HTLV-1-infected cells in HAM.
- 2018 - 2021 Study for oncovirus-mediated epigenetic abnormality in the early phase of tumorigenesis
- 2018 - 2021 Indolent ATLの分子標的同定とEZH1/2阻害薬の適応拡大を目指した研究
- 2016 - 2019 Integrative analysis of epigenome abnormality in the pathogenesis of HTLV-1-associated myelopathy.
- 2015 - 2018 Study for epigenetic abnormality of microRNA in lymphoma biology
- 2015 - 2018 Abnormal differentiation and instability of microRNA regulation in pancreatic carcinogenesis
- 2014 - 2017 Integrated analysis of abnormal expression profiles that define phenotype of ATL cells
- 2012 - 2014 Study of retrovirus latency and its heterogeneity
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Papers (47):
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Jun Mizuike, Kako Suzuki, Shu Tosaka, Yuta Kuze, Seiichiro Kobayashi, Makoto Nakashima, Koji Jimbo, Yasuhito Nannya, Yutaka Suzuki, Kaoru Uchimaru, et al. Rewired chromatin structure and epigenetic gene dysregulation during HTLV-1 infection to leukemogenesis. Cancer Science. 2024
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Makoto Yamagishi, Yuta Kuze, Seiichiro Kobayashi, Makoto Nakashima, Satoko Morishima, Toyotaka Kawamata, Junya Makiyama, Kako Suzuki, Masahide Seki, Kazumi Abe, et al. Mechanisms of action and resistance in histone methylation-targeted therapy. Nature. 2024
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Koji Jimbo, Makoto Yamagishi, Yutaka Suzuki, Kako Suzuki, Motoko Mizukami, Kazuaki Yokoyama, Aki Sato, Tokiko Nagamura-Inoue, Yasuhito Nannya, Kaoru Uchimaru. Progression of adult T-cell leukemia/lymphoma from smoldering to acute type due to branched subclonal evolution. EJHaem. 2023. 4. 4. 1188-1190
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Tomoo Sato, Junji Yamauchi, Naoko Yagishita, Natsumi Araya, Naoki Takao, Yuki Ohta, Eisuke Inoue, Masaki Takahashi, Makoto Yamagishi, Yutaka Suzuki, et al. Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy. Brain : a journal of neurology. 2023
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Akihito Koseki, Natsumi Araya, Makoto Yamagishi, Junji Yamauchi, Naoko Yagishita, Naoki Takao, Katsunori Takahashi, Yasuo Kunitomo, Daisuke Honma, Kazushi Araki, et al. EZH1/2 dual inhibitors suppress HTLV-1-infected cell proliferation and hyperimmune response in HTLV-1-associated myelopathy. Frontiers in microbiology. 2023. 14. 1175762-1175762
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MISC (104):
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山岸誠. 腫瘍ウイルスによるエピゲノム異常とクローン進化に関する統合オミクス解析と創薬研究. 細胞. 2024. 56. 7
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山岸誠. Mechanisms of action and resistance in histone methylation-targeted therapy. 臨床血液、Introduce My Article. 2024
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新谷奈津美, 山岸誠, 清原和裕, 浅原尚美, 中島誠, 荒谷聡子, 荒谷聡子, 八木下尚子, 内丸薫, 佐藤知雄, et al. Neuronal Cell Damage by HTLV-1 infected cell in Patients with HAM/TSP. 日本HTLV-1学会学術集会. 2023. 9th
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鷹尾直誠, 永井香帆, 中島誠, 新谷奈津美, 久世裕太, 鈴木穣, 内丸薫, 山岸誠, 山野嘉久, 山野嘉久. Non-clinical data on the usefulness of MEK inhibitors for HTLV-1-related myelopathy. 日本HTLV-1学会学術集会. 2023. 9th
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中島誠, 中島誠, 永井香帆, 鷹尾直誠, 新谷奈津美, 久世裕太, 鈴木穣, 内丸薫, 山岸誠, 山野嘉久, et al. Exploration of inflammation-inducing factors in HTLV-1 associated myelopathy by integrated omics analysis. 日本HTLV-1学会学術集会. 2023. 9th
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Professional career (1):
Work history (7):
- 2023/04 - 現在 東京大学 医科学研究所 連携准教授
- 2023/04 - 現在 The University of Tokyo Graduate School of Frontier Sciences
- 2022/04 - 2023/03 The University of Tokyo Graduate School of Frontier Sciences
- 2018/05 - 2022/03 The University of Tokyo Graduate School of Frontier Sciences
- 2015/05 - 2018/04 The University of Tokyo Graduate School of Frontier Sciences
- 2011/04 - 2015/04 The University of Tokyo Graduate School of Frontier Sciences
- 2009/04 - 2011/03 エイズ予防財団 リサーチレジデント
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Committee career (5):
- 2024/07 - 現在 Clinical Epigenetics (Springer Nature) Associate Editor
- Frontiers in Virology, Systems biology Review Editor
- Frontiers in Virology, Bioinformatic and Predictive Virology Associate Editor
- Scientific Reports Editorial Board
- 日本HTLV-1学会 評議委員
Awards (10):
- 2024/06 - International Retrovirology Association (IRVA) Prestigious Basic Science Award
- 2017 - 日本血液学会 奨励賞
- 2017 - 第18回国際ヒトレトロウイルスHTLV会議 優秀口演賞
- 2017 - 第18回国際ヒトレトロウイルスHTLV会議 優秀ポスター賞
- 2016 - 米国血液学会 Abstract Achievement Award
- 2016 - 第3回日本HTLV-1学会学術集会 Young Investigator Award
- 2015 - 米国血液学会 Abstract Achievement Award
- 2013 - 第16回国際ヒトレトロウイルスHTLV会議 Young Investigator Award
- 2013 - 日本血液学会 EHA Travel Award for JSH Young Hematologist
- 2010 - Travel award at the Workshop on Viruses, Genes and Cancer in Venus, Italy
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