Rchr
J-GLOBAL ID:201801010966104701   Update date: Jun. 09, 2024

Kamba Keisuke

カンバ ケイスケ | Kamba Keisuke
Research field  (2): Structural biochemistry ,  Biophysics
Research keywords  (8): 生物物理学 ,  Wood Biomass ,  Protein ,  Virus ,  Enzyme ,  Molecular Biology ,  Structural Biology ,  Nucleic Magnetic Resonance
Research theme for competitive and other funds  (3):
  • 2022 - 2025 Development of cancer selective infectious virus vector that slows tumor growth
  • 2019 - 2020 HIVのVifによる異なる2種類の「ヒト防御システム無力化手段」の同時阻害
  • 2017 - 2020 Inactivation mechanism of HIV Vif protein using host cellular proteins against human anti-viral factor
Papers (7):
  • Kazuyuki Kumagai, Keisuke Kamba, Takuya Suzuki, Yuto Sekikawa, Chisato Yuki, Michiaki Hamada, Kayoko Nagata, Akifumi Takaori-Kondo, Li Wan, Masato Katahira, et al. Selection and characterization of aptamers targeting the Vif-CBFβ-ELOB-ELOC-CUL5 complex. Journal of biochemistry. 2024
  • Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira. Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway. Biophysical Journal. 2023
  • Afaf Eladl*, Yudai Yamaoki*, Keisuke Kamba*, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira (*: equally contributed). NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs. Biochemical and Biophysical Research Communications. 2023
  • Li Wan, Keisuke Kamba, Takashi Nagata, Masato Katahira. An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA. Biochimica et Biophysica Acta (BBA) - General Subjects. 2020. 1864. 2. 129346-129346
  • Keisuke Kamba, Takashi Nagata, Masato Katahira. The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring. Phys. Chem. Chem. Phys. 2018. 20. 5. 2976-2981
more...
MISC (52):
  • 兎澤賢太, 神庭圭佑, 岩岡諒, 永田崇, 片平正人. HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体がAPOBEC3A 及び APOBEC3Cの脱アミノ化に及ぼす影響の解析. 第46回日本分子生物学会年会. 2023
  • Shou Waga, Yudai Yamaoki, Afaf Eladl, Keisuke Kamba, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Takashi Nagata, Masato Katahira. NMR analysis on the binding sites of human origin recognition complex subunit 1 to G-quadruplex structure of DNA. The 14th International Symposium of Advanced Energy Science. 2023
  • Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira. HIV-1 Vif directly inhibit against human APOBEC3G deaminases independent of the ubiquitin-proteasome pathway. 23th ISMAR Conference. 2023
  • 兎澤賢太郎, 神庭圭佑, 岩岡諒, 永田崇, 片平正人. HIV-1 Vif-ヒトE3ユビキチンリガーゼ複合体は ヒト抗ウイルス因子APOBEC3Cの脱アミノ化を阻害する. 第45回日本分子生物学会年会. 2022
  • Keisuke Kamba, Li Wan, Satoru Unzai, Ryo Morishita, Akifumi Takaori-Kondo, Takashi Nagata, Masato Katahira. Additive effect of the interactions between the components of HIV-1-Vif: E3 ubiquitin ligase and human APOBEC3G may elevate the antiviral activity of APOBEC3G. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
more...
Lectures and oral presentations  (4):
  • Selection and characterization of aptamers that bind to the complex containing HIV-1 Vif protein
  • HIV Vif-ヒトE3ユビキチンリガーゼ複合体によるAPOBEC3タンパク質の脱アミノ化阻害と核酸を含む3者間の分子間相互作用の解析
    (核酸化学 若手フォーラム 2018 2018)
  • リアルタイム NMR モニタリング法の開発及びヒト抗ウイルス因子APOBEC3Gの脱アミノ化機構の解明
    (第 33 回鴨叡会・生命分子化学科セミナー 2016)
  • NMRによる活性モニタリングに基づいたヒト抗HIV因子APOBEC3Gの脱アミノ化及び動作機構の解明
    (新学術領域研究「理論と実験による柔らかな分子系の機能の科学」第4回全体合宿会議(若手招待講演) 2015)
Education (3):
  • 2012 - 2016 Kyoto University Energy science
  • 2010 - 2012 Nagoya University Science
  • 2006 - 2010 Nagoya University Science Physics
Work history (2):
  • 2018/04 - 現在 Ritsumeikan University Pharmacy Part-time Lecturer
  • 2016/06 - 現在 Kyoto University Institute of Advanced Energy Postdoctoral fellow
Awards (6):
  • 2017 - 京都大学 平成28年度 京都大学 研究連携基盤 次世代研究者支援(後期)
  • 2016/08 - The XXVIIth International Conference on Magnetic Resonance in Biological Systems Young InvestigatorAward Deamination mechanism coupled with sliding along single-stranded DNA of anti-HIV factor APOBEC3G as investigated by real-time NMR spectroscopy
  • 2016/03 - 京都大学エネルギー理工学研究所 平成27年度京都大学エネルギー理工学研究所表彰 学生賞
  • 2015/11 - 第54回NMR討論会 優秀若手ポスター賞(太陽日酸賞) リアルタイムNMR法の新たな展開 -抗HIVタンパク質APOBECG3Gの認識ヌクレオチド、DNA上のスライディング及びエピジェネティクスとの関連に関する新知見-
  • 2015 - 日本核磁気共鳴学会 平成27年度第1回若手研究者渡航費助成金
Show all
Association Membership(s) (6):
THE SPECTROSCOPICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page