Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, Takeshi Iwatsubo, Hideyuki Okano. Inhibitory roles of Apolipoprotein E Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024
Hirotaka Watanabe, Rei Murakami, Kazuya Tsumagari, Satoru Morimoto, Tadafumi Hashimoto, Kent Imaizumi, Iki Sonn, Kaoru Yamada, Yuko Saito, Shigeo Murayama, et al. Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model. Stem Cell Reports. 2023
Sho Yoshimatsu, Fumiko Seki, Junko Okahara, Hirotaka Watanabe, Hiroki Sasaguri, Yawara Haga, Jun-ichi Hata, Tsukasa Sanosaka, Takashi Inoue, Takayuki Mineshige, et al. Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Neuroscience Research. 2022
Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okano. Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022. 42. 1. 20-20
Raymond J. Kelleher, Dan Xia, Hirotaka Watanabe, Bei Wu, Sang Hun Lee, Yan Li, Evgeny Tsvetkov, Vadim Bolshakov, Jie Shen. Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. ANNALS OF NEUROLOGY. 2015. 78. S84-S85
Development of novel stem cell tool to examine physiological functions of presenilin/γ-secretase in human neurons
(NEURO2019 2019)
Presenilin and Alzheimer’s.
(Blue Ribbon Panel Meeting 2018)
The roles of γ-secretase and its substrates on the pathogenesis of neurodegenerative dementia.
(National Institute of Genetics- the 1801st Biological Symposium 2015)
