Rchr
J-GLOBAL ID：201801011001579401
Update date: Nov. 16, 2024
Uruno Akira
ウルノ アキラ | Uruno Akira
Affiliation and department：
Homepage URL (1)：
http://www.dmbc.med.tohoku.ac.jp/official/index.html
Research field (5)：
Basic brain sciences
, Metabolism and endocrinology
, Medical biochemistry
, Nutrition and health science
, Pathobiochemistry
Research keywords (5)：
Alzheimer's disease
, Nrf2
, Oxidative stress
, Diabetes mellitus
, Metabolism
Research theme for competitive and other funds (19)：
- 2020 - 2023 Glutathione regulations in Alzheimer's disease
- 2017 - 2020 Basic Research for Development of Chemical Surgery
- 2017 - 2020 Role of Nrf2 in Alzheimer's disease with diabetes mellitus
- 2017 - 2020 酸化ストレス増加が引き起こすインスリン抵抗性の病態解明とNrf2の役割(国際共同研究強化)
- 2017 - 2020 Nrf2を標的にした糖尿病に合併する認知症発症予防法の開発
- 2017 - 2019 Investigation on imaging of distribution of organic molecules in meteorites
- 2017 - 2019 Roles of oxidative stress in metabolic regulations(Fostering Joint International Research)
- 2014 - 2017 The role of Nrf2 in oxidative stress-mediated insulin resistance
- 2014 - 2016 The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model mice
- 2012 - 2015 Roles of stress-responsive transcription factors in health and disease
- 2012 - 2014 The role of Keap1-Nrf2 system in obesity-induced pancreatic beta-cell dysfunctions
- 2010 - 2012 膵β細胞におけるKeap1-Nrf2システムによる酸化ストレス応答機構の解明
- 2010 - 2011 The role of Keap1-Nrf2 system in oxidative stress response of pancreatic β-cells
- 2007 - 2010 p38 MAPKを標的にした動脈硬化性疾患に対する新規治療法の開発
- 2007 - 2009 p38MAPKを標的にした動脈硬化性疾患に対する新規治療法の開発
- 2005 - 2007 腎微小循環における肝細胞増殖因子の病態生理学的意義の解明
- 2007 - 2007 レチノイン酸による血管内皮におけるPI3キナーゼ調節機構の解明
- 2006 - 2007 EFFECTS OF ALL-TRANS RETINOIC ACID AND RETINOIDS ON ANGIOGENESIS
- 2005 - 2006 腎微小循環における肝細胞増殖因子の病態生理学的意義の解明
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Papers (195)：
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Akira Uruno, Shiori Kadoguchi-Igarashi, Ritsumi Saito, Shohei Koiso, Daisuke Saigusa, Ching-Tung Chu, Takafumi Suzuki, Takashi Saito, Takaomi C Saido, Antonio Cuadrado, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice. Journal of biochemistry. 2024
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Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension research : official journal of the Japanese Society of Hypertension. 2024
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Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, Mana Kogure, Naoki Nakaya, Naoya Fujino, Tsutomu Tamada, Chikashi Iwasaki, Manami Suzuki, et al. Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation. The journal of allergy and clinical immunology. Global. 2024. 3. 3. 100253-100253
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Eiichi N Kodama, Makiko Taira, Hideyasu Kiyomoto, Tomohiro Nakamura, Satoshi Nagaie, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara, Fuji Nagami, Akira Uruno, et al. Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project. JMA journal. 2024. 7. 3. 342-352
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Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of atherosclerosis and thrombosis. 2024
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MISC (73)：
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石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 宇留野晃, 吉田清香, 高田菜生子, 藤岡俊亮, 西村尭幸, et al. 父母と小児の眼科的検査値の関連:三世代コホート調査. 日本疫学会学術総会講演集(Web). 2024. 34th
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中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, et al. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗. 東北公衆衛生学会誌. 2022. 71. 28-28
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小池海斗, 三枝大輔, 三枝大輔, 宇留野晃, 宇留野晃, 鈴木隆史, 鈴木隆史, 福内友子, 山岡法子, 芝大, et al. Lipidomic variations by the oxidative stress in the space flight. 質量分析総合討論会講演要旨集. 2022. 70th
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小池海斗, 三枝大輔, 三枝大輔, 宇留野晃, 宇留野晃, 鈴木隆史, 鈴木隆史, 福内友子, 山岡法子, 芝大, et al. Lipidomic Variations by the Oxidative Stress in the Space Flight. Journal of the Mass Spectrometry Society of Japan. 2022. 70. 4
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Furukawa Yoshihiro, Saigusa Daisuke, Kano Kuniyuki, Uruno Akira, Saito Ritsumi, Ito Motoo, Matsumoto Megumi, Aoki Jyunken, Yamamoto Masayuki, Nakamura Tomoki. High-resolution imaging mass spectrometry of CHN compounds in meteorites: organic synthesis in the early solar system. Abstracts of Annual Meeting of the Geochemical Society of Japan. 2022. 69. 190
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Books (3)：
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Molecular Nutrition and Diabetes, 1st Edition.
Elsevier Science B.V. 2015
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クッシング症候群診療マニュアル
診断と治療社 2009
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Control and Diseases of Sodium Dependent Transporter Proteins and Ion Channels.
Elsevier Science B.V. 2000
Lectures and oral presentations (7)：
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Nrf2を標的としたアルツハイマー病の治療戦略
(第4回 医薬品開発研究センターシンポジウム 「脳と創薬」 2021)
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The multiple functions of Nrf2 in diabetes mellitus and obesity
(The Environmental Response V 2019)
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The Keap1-Nrf2 system and oxidative damage in diabetes mellitus
(第61回日本糖尿病学会年次学術集会 2018)
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Nrf2による代謝恒常性維持機構の解明
(第396回東北医学会例会)
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糖尿病におけるKeap1-Nrf2系の役割
(第89回日本生化学会大会)
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Education (2)：
- 1998 - 2004 Tohoku University Graduate School of Medicine
- 1992 - 1998 Tohoku University School of Medicine
Professional career (1)：
Work history (7)：
Awards (9)：
- 2018 - 平成29年度宮城県医師会医学奨励賞
- 2018 - 平成29年度坂田賞
- 2018 - 東北大学医学部奨学賞金賞
- 2017 - 日本生化学会東北支部奨励賞
- 2011 - 匂坂記念賞
- 2010 - International Symposium for Aldosterone and Related Substances in Hypertension Young Investigator’s award
- 2008 - 平成19年度宮城県医師会医学奨励賞
- 2008 - 平成19年度坂田賞
- 2008 - 東北大学医学部奨学賞銀賞
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Association Membership(s) (5)：
THE JAPAN SOCIETY OF HUMAN GENETICS
, 日本内科学会
, 日本内分泌学会
, 日本分子生物学会
, 日本生化学会
