Rchr
J-GLOBAL ID：201801011080431856   Update date: May. 23, 2024

Yagyu Shigeki

ヤギュウ シゲキ | Yagyu Shigeki
Affiliation and department：
Shinshu University Shinshu University-Innovative Research and Liaison Organization (SUIRLO)

About Shinshu University Shinshu University-Innovative Research and Liaison Organization (SUIRLO)


Job title： Professor
Other affiliations (1)：
Homepage URL  (1)： http://www.f.kpu-m.ac.jp/k/ped/examination/staff/yagyu.html
Research field  (4)： Medical biochemistry ,  Medical biochemistry ,  Tumor diagnostics and therapeutics ,  Fetal medicine/Pediatrics
Research keywords  (4)： Cell Therapy ,  Gene Therapy ,  Oncology ,  Pediatrics
Research theme for competitive and other funds  (25)：
  • 2023 - 2026 Development of gene cell therapy using mesenchymal stromal cells for neuroblastoma
  • 2023 - 2026 Development of novel gene therapy for rhabdomyosarcoma
  • 2022 - 2025 The development of CAR-T therapy targeting FLT3 and CD19 for infant acute lymphoblastic leukemia
  • 2021 - 2024 EPHB4受容体高発現悪性固形腫瘍を対象とした非ウイルス遺伝子改変CAR-T細胞療法の第一相医師主導治験
  • 2020 - 2023 神経芽腫の自然退縮・分化に関わる新規予後良好分子マーカーの検討と治療応用
Show all
Papers (70)：
  • Hajime Kamiya, Shuhei Komatsu, Yusuke Takashima, Ryo Ishida, Hiroshi Arakawa, Keiji Nishibeppu, Jun Kiuchi, Taisuke Imamura, Takuma Ohashi, Hiroki Shimizu, et al. Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer. British journal of cancer. 2023
  • Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, et al. Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers. Molecular therapy oncolytics. 2023. 31. 100728-100728
  • MASAFUMI IGUCHI, SHIGEKI YAGYU, KOSUKE KAMBE, MAYUMI HIGASHI, SHIGEHISA FUMINO, TSUNAO KISHIDA, TOMOKO IEHARA, OSAM MAZDA, TATSURO TAJIRI. Development of anti-GD2 Antibody-producing Mesenchymal Stem Cells as Cellular Immunotherapy. Anticancer Research. 2023. 43. 6. 2417-2424
  • Chika Shoji, Ken Kikuchi, Hideki Yoshida, Mitsuru Miyachi, Shigeki Yagyu, Kunihiko Tsuchiya, Takaaki Nakaya, Hajime Hosoi, Tomoko Iehara. In ovo chorioallantoic membrane assay as a xenograft model for pediatric rhabdomyosarcoma. Oncology reports. 2023. 49. 4
  • Shigeki Yagyu, Yozo Nakazawa. piggyBac-transposon-mediated CAR-T cells for the treatment of hematological and solid malignancies. International journal of clinical oncology. 2023
ｍore...
MISC (226)：
  • 柳生 茂希. 【CAR-T細胞療法の最前線-現状と残された課題】非ウイルス遺伝子改変CAR-T細胞の開発動向. 医学のあゆみ. 2024. 288. 3. 205-210
  • 柳生 茂希. CAR-T細胞療法の小児がんへの応用:白血病から固形腫瘍まで 固形腫瘍に対するCAR-T細胞療法の開発と臨床応用. 日本癌治療学会学術集会抄録集. 2023. 61回. CCWS3-2
  • 柳生 茂希. 非ウイルス遺伝子改変CAR-T細胞の開発と臨床応用. 日本癌治療学会学術集会抄録集. 2023. 61回. YP2-4
  • 柳生 茂希. 小児がん研究最前線 小児固形腫瘍に対するピギーバックトランスポゾンCAR-T細胞療法の開発(Cutting edge of pediatric cancer research Memory-rich CAR-T cell engineering by piggyBac transposon system for pediatric solid tumor). 日本癌学会総会記事. 2023. 82回. 17-17
  • 柳生 茂希. 国内のCAR-T療法開発と実臨床の現状 固形腫瘍に対する非ウイルス遺伝子改変CAR-T細胞療法の開発. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 46-46
ｍore...
Patents (4)：
  • CAR発現免疫細胞を含む細胞集団の製造方法
  • ALKを標的とするキメラ抗原受容体発現細胞
  • 体液由来検体を用いた神経芽腫の遺伝子異常検出方法
  • 殺細胞効果を有するキメラ抗原受容体遺伝子改変リンパ球
Lectures and oral presentations  (8)：
  • PAX3-NCOA2 PLAYS A DUAL ROLE IN TUMORIGENESIS OF EMBRYONAL RHABDOMYOSARCOMA
    (PEDIATRIC BLOOD & CANCER 2011)
  • Dual role of PAX3-NCOA2 in tumorigenesis of rhabdomyosarcoma
    (CANCER RESEARCH 2011)
  • MUSCLE SPECIFIC MICRORNAS AS NOVEL BIOMARKERS FOR RHABDOMYOSARCOMA
    (PEDIATRIC BLOOD & CANCER 2010)
  • Specific MLL Fusion Partners Affect the Sensitivity of Human and Murine Leukemic Cell Lines to Demethylating Agents
    (BLOOD 2010)
  • Monocytic Differentiation of Myeloid Leukemia Cell Lines Induced by ATRA and 5-Aza-2 '-Deoxycitidine.
    (BLOOD 2009)
ｍore...
Education (2)：
  • 2005 - 2009 Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • 1994 - 2000 Kyoto Prefectural University of Medicine
Professional career (1)：
  • 医学博士 (京都府立医科大学)
Work history (4)：
  • 2022/04 - 現在 Shinshu University Shinshu University-Innovative Research and Liaison Organization (SUIRLO) Professor
  • 2015/08 - 現在 Kyoto Prefectural University of Medicine Graduate School of Medical Science, Department of Pediatrics Assistant Professor
  • 2000/04 - 現在 Kyoto Prefectural University of Medicine Department of Pediatrics
  • 2013/02 - 2015/08 Baylor College of Medicine Center for Cell and Gene Therapy Postdoctoral Associate
Awards (5)：
  • 2019/02 - International Cancer Research Symposium of Training Plan for Oncology Professionals Merit Award
  • 2017/11 - 日本小児血液がん学会 日本小児血液がん学会学術賞
  • 2015/05 - 18th Annual Meeting of American Society of Gene and Cell therapy Meritorious Abstract Travel Award
  • 2012/08 - The Rotary Foundation Global Grant Scholarship
  • 2011/10 - 43rd Congress of the International Society of Paediatric Oncology Best Poster Award
Association Membership(s) (6)：
AMERICAN SOCIETY OF GENE AND CELL THERAPY ,  THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY ,  THE JAPANESE SOCIETY OF GENE AND CELL THERAPY ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF HEMATOLOGY ,  JAPAN PEDIATRIC SOCIETY
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