Watanabe Nobumoto

ワタナベノブモト | Watanabe Nobumoto

Affiliation and department：
Other affiliations (1)：

Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences

Research field (2)： Biochemistry , Cell biology

Research theme for competitive and other funds (19)：

2021 - 2024 正常-がん細胞間作用に基づくがん防御機構の化学生物学的解析
2021 - 2023 Screening for small molecule competitors of the phosphorylated substrates of beta-TrCP and their application for the induction of targeted protein degradation
2019 - 2021 Screening for small molecule competitors of the phosphorylated substrates of beta-TrCP and their application for the induction of targeted protein degradation
2012 - 2016 Screening of phosphorylation dependent 14-3-3 binding inhibitors
2009 - 2011 Analyses of the role of peptidyl prolyl isomerase on the cell cycle progression through small moleule inhibitors

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Papers (107)：

Zhou, J., Pathak, J.L., Wu, L., Chen, B., Cao, T., Wei, W., Wu, X., Chen, G., Watanabe, N., Li, X., et al. Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis. Free Radical Biology and Medicine. 2024. 218
Liu, F., Wu, Q., Liu, Q., Chen, B., Liu, X., Pathak, J.L., Watanabe, N., Li, J. Dental pulp stem cells-derived cannabidiol-treated organoid-like microspheroids show robust osteogenic potential via upregulation of WNT6. Communications Biology. 2024. 7. 1
Zhou, J., Pathak, J.L., Cao, T., Chen, B., Wei, W., Hu, S., Mao, T., Wu, X., Watanabe, N., Li, X., et al. CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2024. 1870. 4
Florence Hui Ping Tan, Andrew Chung Jie Ting, Nazalan Najimudin, Nobumoto Watanabe, Shaharum Shamsuddin, Azalina Zainuddin, Hiroyuki Osada, Ghows Azzam. 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer’s Disease Drosophila. The Journals of Gerontology: Series A. 2023. 78. 11
Zhou, J., Pathak, J.L., Liu, Q., Hu, S., Cao, T., Watanabe, N., Huo, Y., Li, J. Modes and Mechanisms of Salivary Gland Epithelial Cell Death in Sjogren's Syndrome. Advanced Biology. 2023

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MISC (6)：

河村達郎, 河村達郎, 二村友史, 室井誠, 室井誠, 川谷誠, 川谷誠, SHANG Rchang, JANNING Petra, 近藤恭光, et al. がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
New Technologies to Accelerate the Screening of Novel Antitumor Compounds. 2013. 32. 6. 655-659
Cell cycle. 2012. 70. 1018. 79-85
荻田紀子, 野川俊彦, 森美穂子, 浦本昌和, 真田英美子, 辻田和彦, 根岸恵則, 渡邉信元, 長田裕之. 微生物代謝産物からのPBD依存結合阻害剤の探索研究. 日本農芸化学会大会講演要旨集. 2009. 2009
Cell cycle defects in cancer cells. Japanese journal of clinical medicine. 2009. 67. 71-76

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Education (3)：

- 1987 東京大学大学院理学系研究科博士課程(動物学)
- 1984 東京大学大学院理学系研究科修士課程(動物学)
- 1982 The University of Tokyo Faculty of Science Department of Biological Sciences

Professional career (1)：

Work history (13)：

2023/07 - 現在广州医科大学附属口腔医院客座教授
2018/05 - 現在理化学研究所・環境資源科学研究センター技術基盤部門・化合物リソース開発研究ユニット
2014/04 - 2023/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
2017/03 - 2022/03 理化学研究所・環境資源科学研究センターバイオプローブ応用研究ユニットユニットリーダー
2006/04 - 2018/12 マレーシア工科大学客員教授

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Committee career (1)：

Association Membership(s) (3)：

THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION

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