Sakurai Yasutaka

Affiliation and department：

Research field (4)： Laboratory animal science , Environmental effects of chemicals , Environmental effects of radiation , Molecular biology

Research keywords (5)： drug resistance , mutation , DNA repair , Translesion DNA synthesis , DNA damage tolerance

Research theme for competitive and other funds (6)：

2021 - 2024 術前化学療法進行胃癌に対する治療効果とDNA修復関連蛋白REV7の発現との関連
2021 - 2024 DNA損傷トレランスタンパク質REV7を介した紫外線誘発皮膚癌の発生機序の解明
2019 - 2021 Elucidation of the function of DNA damage tolerance in UV-induced skin cancer development
2018 - 2021 Elucidation of novel molecular mechanisms for maintenance of spermatogonial stem cells and gametogenesis in the testis
2015 - 2019 A study on DNA damage tolerance pathways as novel targets for cancer therapy

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Papers (15)：

Yuko Shimada, Takuya Kato, Yasutaka Sakurai, Hitoe Watanabe, Mayu Nonaka, Natsumi Nanaura, Masaaki Ichinoe, Yoshiki Murakumo. Identification of the promoter region regulating the transcription of the REV7 gene. Biochemical and biophysical research communications. 2023. 662. 8-17
Yoshiki Murakumo, Yasutaka Sakurai, Takuya Kato, Hiroshi Hashimoto, Masaaki Ichinoe. REV7 in Cancer Biology and Management. Cancers. 2023. 15. 6
Masayoshi Tadehara, Takuya Kato, Kai Adachi, Akihiro Tamaki, Yurika Kesen, Yasutaka Sakurai, Masaaki Ichinoe, Wasaburo Koizumi, Yoshiki Murakumo. Clinicopathological Significance of BRCAness in Resectable Pancreatic Ductal Adenocarcinoma and Its Association With Anticancer Drug Sensitivity in Pancreatic Cancer Cells. Pancreas. 2022. 51. 2. 183-189
Kai Adachi, Yasutaka Sakurai, Masaaki Ichinoe, Masayoshi Tadehara, Akihiro Tamaki, Yurika Kesen, Takuya Kato, Shinji Mii, Atsushi Enomoto, Masahide Takahashi, et al. CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer. Virchows Archiv : an international journal of pathology. 2021. 480. 4. 819-829
Akiyoshi Hoshino, Chika Nakayama, Shi-Xu Jiang, Yasutaka Sakurai, Takuya Kato, Yoshiko Numata, Atsuko Umezawa, Masaaki Ichinoe, Yoshiki Murakumo. Upregulation of REV7 correlates with progression of malignant melanoma. Pathology international. 2021

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MISC (7)：

櫻井靖高, 村雲芳樹. DNA修復機構をターゲットとした癌の治療戦略. 病理と臨床. 2017. 35. 4. 382-384
Yasutaka Sakurai, Masayuki Yokoi, Fumio Hanaoka. Roles of DNA polymerases eta and iota in UV-induced mutagenesis. DNA REPAIR. 2015. 28. 143-143
櫻井靖高, 横井雅幸, 塚本徹哉, 魏民, 鰐渕英機. 紫外線に誘発される突然変異においてDNAポリメラーゼ・イータとイオタが皮膚細胞と組織で果たす役割(Roles of DNA polymerases eta and iota in UV-induced mutagenesis of skin cells and tissues). 日本病理学会会誌. 2015. 104. 1. 393-393
櫻井靖高, 横井雅幸, 塚本徹哉, 小田司, 魏民, 山下孝之, 鰐渕英機, 立松正衛, 村雲芳樹, 花岡文雄. 紫外線照射DNAの損傷乗り越え複製においてDNAポリメラーゼイータとイオタが果たす生理的役割(Physiological roles of DNA polymerases η and ι in translesion synthesis past UV-induced DNA damage). 日本癌学会総会記事. 2014. 73回. P-3076
櫻井靖高, 横井雅幸, 大雲剛志, 塚本徹哉, 立松正衛, 魏民, 鰐渕英機, 花岡文雄. UV誘発性突然変異およびDNA損傷トレランスにおけるDNAポリメラーゼηおよびιの役割(Roles of DNA polymerases η and ι in UV-induced mutagenesis and DNA damage tolerance). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 2P-0456

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Education (1)：

Professional career (1)：

Work history (1)：

Committee career (1)：

Awards (2)：

Association Membership(s) (2)：

THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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