HIRAI Makoto

Research field (1)： Parasitology

Research theme for competitive and other funds (24)：

2022 - 2026 アフリカに初めて出現した第一選択薬アルテミシニンへの耐性マラリア:蔓延機序の解明
2018 - 2021 Clarification of host adaptation mechanisms by using mutator malaria parasite
2017 - 2021 New interactome strategy elucidating the fertilization mechanism of malaria parasite
2017 - 2020 Predicting the emergence of drug-resistant malaria: Development of a comprehensive laboratory evolution system with accelerated evolution system
2016 - 2020 Comprehensive elucidation of fitness cost in drug-resistant malaria parasites through while life cycle

2015 - 2018 Method for mutation in organelle genome by CRISPR/CAS9

2015 - 2018 Development of a new transmission-blocking method against malaria, using rare sugar-containing sugar solution as food for vector mosquitoes

2014 - 2016 超加速進化型オルガネラゲノムを持つマラリア原虫の創成と予測進化学への応用

2012 - 2016 Generation of rodent malaria parasite with high mutation rate and confirmation of its usefulness for next generation of malariology

2012 - 2015 マラリア原虫GCS1を基盤とした受精メカニズムの解明

2012 - 2015 Identification of mosquito-specific factors which promote growth and differentiation of malaria parasite in the vector mosquito

2011 - 2011 Establishment of an experimental model system for a highly accelerated evolution using mutator malaria parasites generated by the disparity mutagenesis

2010 - 2011 マラリア原虫配偶子認識・膜融合機構の解明とその普遍性の検証

2009 - 2010 受精決定因子pbgcs1を基軸としたマラリア原虫受精メカニズムの解明

2008 - 2010 Molecular analyses of G6PD variants in malaria endemic areas in Asian and African countries

2008 - 2010 The mechanisms of sexual reproduction of malaria parasites

2005 - 2007 Molecular analysis of G6PD variants in malaria endemic areas

2005 - 2006 逆遺伝学的手法によるマラリア原虫生殖母体分化の分子機構解明

2004 - 2005 How malaria parasites move from the skin to the liver or other organs after injected by mosquitoes?

2003 - 2004 熱帯熱マラリア原虫生殖母体分化の分子機構の解明

2002 - 2004 Molecular analysis of G6PD variants in Asian Countries

2001 - 2002 Generation of transgenic anopheline mosquitoes refractory to malaria parasite by using gene manipulation

2000 - 2001 MOLECULAR ANALYSIS OF G6PD VARIANTS IN ASIA

2000 - 2001 STUDIES ON GAMETOCYTA ACTIVATING FACTOR IN THE SALIVARY GRAND OF ANOPHELINE MOSQUITOES

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Papers (66)：

Naoko Yoshida, Haruhisa Kikuchi, Makoto Hirai, Betty Balikagala, Denis A Anywar, Hikari Taka, Naoko Kaga, Yoshiki Miura, Naoyuki Fukuda, Emmanuel I Odongo-Aginya, et al. A longer-chain acylated derivative of Dictyostelium differentiation-inducing factor-1 enhances the antimalarial activity against Plasmodium parasites. Biochemical pharmacology. 2024. 225. 116243-116243
Naoyuki Fukuda, Naoko Yoshida, Betty Balikagala, Ibuki Tsuru, Mie Ikeda, Makoto Hirai, Denis A Anywar, Emannuel I Odongo-Aginya, Toshihiro Mita. Detection of drug-resistant malaria in resource-limited settings: efficient and high-throughput surveillance of artemisinin and partner drug resistance. The Journal of antimicrobial chemotherapy. 2024
Toshihiro Mita, Makoto Hirai, Yoshiko Maki, Saifun Nahar, Naoko Yoshida, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara. Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo. Biochemical pharmacology. 2021. 194. 114834-114834
Makoto Hirai, Akimasa Maeta, Toshiyuki Mori, Toshihiro Mita. Pb103 Regulates Zygote/Ookinete Development in Plasmodium berghei via Double Zinc Finger Domains. Pathogens (Basel, Switzerland). 2021. 10. 12
Masato Yamauchi, Makoto Hirai, Shin-Ichiro Tachibana, Toshiyuki Mori, Toshihiro Mita. Fitness of sulfadoxine-resistant Plasmodium berghei harboring a single mutation in dihydropteroate synthase (DHPS). Acta tropica. 2021. 222. 106049-106049

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MISC (33)：

森稔幸, 平井誠, 美田敏宏. Female-side fertilization factors of malaria parasite, identified by biotinylation. 日本寄生虫学会大会プログラム・抄録集. 2020. 89th
室田直紀, 神保圭佑, 細井賢二, 北村裕梨, 箕輪圭, 遠藤周, 安部信平, 福田直到, 橘真一郎, 森稔幸, et al. サクラマスの摂食による感染が疑われた日本海裂頭条虫症の1例. 日本小児科学会雑誌. 2019. 123. 6. 1059-1059
室田直紀, 神保圭佑, 細井賢二, 北村裕梨, 箕輪圭, 遠藤周, 安部信平, 福田直到, 橘真一郎, 森稔幸, et al. サクラマスの摂食による感染が疑われた日本海裂頭条虫症の1例. 日本小児科学会雑誌. 2019. 123. 6. 1059-1059
Olivo Miotto, Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Richard D. Pearson, Roberto Amato, Sonia Morgado Goncalves, et al. EMERGENCE OF ARTEMISININ-RESISTANT PLASMODIUM FALCIPARUM WITH KELCH13 C580Y MUTATIONS IN PAPUA NEW GUINEA. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019. 101. 582-583
Sayuki Ochiai, Julie Maeda, Makoto Hirai, Toshihiro Mita, Toshiyuki Mori. SYNTHETIC BIOTIN LIGASE ENABLES TO LABEL SURFACE INVASION FACTORS OF CULTURED HUMAN MALARIA PARASITE, PLASMODIUM FALCIPARUM. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019. 101. 129-129

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