Mitsunaga Makoto

Research field (3)： Gastroenterology , Biomedical engineering , Tumor diagnostics and therapeutics

Research theme for competitive and other funds (7)：

2022 - 2024 機能性高分子化合物による新規プレシジョンメカノセラピーの開発
2021 - 2024 Development of a theranostic system for abnormal angiogenesis
2018 - 2021 Nanotheranostic system for cancer with human safety energy device
2017 - 2019 Antibody-selective elimination of drug-resistant pathogens with near-infrared light
2014 - 2018 Development of molecular-specific cancer theranostics utilizing near-infrared light and monoclonal antibody

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Papers (55)：

Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga. Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses. Nature protocols. 2023
Makoto Mitsunaga, Kimihiro Ito, Takashi Nishimura, Hironori Miyata, Kei Miyakawa, Takeshi Morita, Akihide Ryo, Hisataka Kobayashi, Yoshimitsu Mizunoe, Tadayuki Iwase. Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens. Communications Biology. 2022. 5. 1
Yasuyoshi Hatayama, Yutaro Yamaoka, Takeshi Morita, Sundararaj Stanleyraj Jeremiah, Kei Miyakawa, Mayuko Nishi, Yayoi Kimura, Makoto Mitsunaga, Tadayuki Iwase, Hirokazu Kimura, et al. Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy. Viruses. 2022. 14. 10. 2153-2153
Takashi Nishimura, Makoto Mitsunaga, Kimihiro Ito, Hisataka Kobayashi, Masayuki Saruta. Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2020. 23. 1. 82-94
Takashi Nishimura, Makoto Mitsunaga, Ryoichi Sawada, Masayuki Saruta, Hisataka Kobayashi, Noriko Matsumoto, Toru Kanke, Hiroyuki Yanai, Koji Nakamura. Photoimmunotherapy targeting biliary-pancreatic cancer with humanized anti-TROP2 antibody. Cancer medicine. 2019. 8. 18. 7781-7792

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MISC (118)：

Tadayuki Iwase, Makoto Mitsunaga. Photoimmunotherapy as a targeted elimination strategy. 2024. 42. 6. 952-955
光永眞人, 西村尚, 伊藤公博, 宮川敬, 梁明秀, 小林久隆, 岩瀬忠行. PITの現状と展望光免疫療法を応用した標的選択的な病原体除去法photoimmuno-antimictobial strategyの開発. 日本レーザー医学会誌. 2023. 44. 3. 304-304
粟田潤, 酒寄千晶, 澁谷尚希, 宮崎亮佑, 上田薫, 豊永貴彦, 櫻井俊之, 光永眞人, 山崎琢士, 猿田雅之. 基礎疾患のない高齢者に生じたサイトメガロウイルス巨大十二指腸潰瘍の一例. Progress of Digestive Endoscopy. 2023. 103. Suppl. s119-s119
光永眞人, 西村尚, 猿田雅之, 小林雅邦, 炭山和毅, 小林久隆. 【IEEを使いこなす】分子イメージングの現況と将来像. 胃と腸. 2022. 57. 13. 1709-1718
西村尚, 光永眞人. マウス潰瘍性大腸炎関連大腸癌に対する近赤外セラノスティクス内視鏡(Near-infrared theranostic molecular endoscopy in a murine model of colitis-associated colorectal cancer). 日本癌学会総会記事. 2022. 81回. J-3011

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Patents (5)：

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