NAKA KAZUHITO

ナカカズヒト | NAKA KAZUHITO

Affiliation and department：
Job title：准教授

Research field (1)： Tumor biology

Research keywords (10)： fatigue , Post-extertional malaise, PEM , ME/CFS , Brain fog , Long COVID , SARS-CoV-2 , TGF-beta/FOXO , Chronic Myelogenous Leukemia (CML) Stem Cells , POTS , Stem Cell Biology

Research theme for competitive and other funds (19)：

2021 - 2024 Role of omega-3 fatty acid metabolism in cancer stem cells
2020 - 2023 Role of lysophospholipid metabolism enzyme Gdpd3 in regulating lipoquality in cancer stem cells
2017 - 2020 p38 MAPK is involved in the development of resistance to chemotherapy in urothelial carcinoma
2018 - 2020 アミノ酸・ペプチド代謝による白血病幹細胞の制御機構の解析
2015 - 2020 共同研究: カルナバイオサイエンス

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Papers (93)：

Arai M., Hanada M., Moriyama H., Ohmoto H., Miyake T., Naka K., Sawa M. Design and synthesis of novel thiazole-derivatives as potent ALK5 inhibitors. Bioorganic Medicinal Chemistry Letters. 2024. 108. 129797
Kazuhito Naka, Akira Ooshima, Takemasa Sakaguchi, Yusuke Sotomaru, Kanae Koike, Naoya Sakamoto, Tomo-o Ishikawa, Seong-Jin Kim, and Masaaki Sawa. SARS-CoV-2 RNA-dependent RNA Polymerase is Linked to Mitochondrial Dysfunction in Mouse Heart. Research Square (preprint). 2024
Mino T, Ureshino H, Ueshima T, Kashimoto N, Yamaguchi T, Naka K, Inaba T, Ichinohe T. A novel anticancer quinolone, (R)-WAC-224, has anti-leukemia activities against acute myeloid leukemia. Investigational New Drugs. 2023
Tamai M, Fujisawa S, Thu TN, Komatsu C, Kagami K, Kamimoto K, Omachi K, Kasai S, Harama D, Watanabe A, Akahane K, Goi K, Naka K, Kaname T, Teshima T, and Inukai T. Generation of Philadelphia chromosome in human leukemia by DNA breaks on the BCR and ABL1 genes using CRISPR/Cas9 system. Cancer Gene Therapy,. 2022
Kawakami S, Tsuma-Kaneko M, Sawanobori M, Uno T, Nakamura Y, Matsuzawa H, Suzuki R, Onizuka M, Yahata T, Naka K, Ando K, Kawada H. Pterostilbene administration downregulates BCR/ABL and induces apoptosis in T315I-mutated BCR/ABL-positive leukemic cells. Sci. Rep. 2022. 12. 1. 704-704

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MISC (22)：

鵜飼翔一, 坂本直也, 本間りりの, 谷山大樹, ファム・クオックタング, 高島剛志, 原田健司, 仲一仁, 田邊和照, 大段秀樹, et al. 5-FU耐性胃癌オルガノイドの樹立とその癌遺伝学的解析. 日本癌学会総会記事. 2020. 79回. OJ18-1
Yoshihiro Takihara, Yoshinori Ohno, Kyoko Suzuki-Takedachi, Mimoko Santo, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Kazuhito Naka. LOW DOSE -RATE IRRADIATION SPECIFICALLY AFFECTS HEMATOPOIETIC STEM CELLS. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S101-S102
TGF-β-FOXO Signaling Regulates Therapeutic Resistance in CML Stem Cells. Journal of the Juzen Medical Society. 2010. 119. 4. 179-183
TGF-β-FOXO signalling maintains CML stem cells. 2010. 61. 6. 732-736
Kazuhito Naka, Takayuki Hoshii, Yuko Tadokoro, Takako Ooshio, Yukio Kondo, Shinji Nakao, Noboru Motoyama, Atsushi Hirao. Molecular Mechanism Regulating Foxo In Leukemia Initiating Cells of Chronic Myeloid Leukemia. BLOOD. 2010. 116. 21. 1388-1388

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Patents (6)：

Therapeutic agent for chronic myeloid leukemia (Application, WO/2016/159301 A1, October 6th, 2016)
A composition for inhibiting growth or proliferation of chronic myelogenous leukemia cancer stem cell and a method thereof (Application, WO/2016/159575 A2, October 6th, 2016)
Pharmaceutical composition for preventing or treating chronic myeloid leukemia and method using the same (Application, WO/2016/126028 A1, August 11th, 2016)
慢性骨髄性白血病治療剤及びそのスクリーニング方法 (特許6082869, 2017.2.3. )
白血病治療剤及び該治療剤の新規なスクリーニング (特許5555897, 2014.6.13.)

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Books (41)：

細胞培養・組織培養の技術第4版
朝倉書店 2023 ISBN:9784254310962
EBM 血液疾患の治療 2023-2024
中外医学社 2022
慢性骨髄性白血病-最新の診断と治療-
日本臨牀社 2021
医学のあゆみ
医歯薬出版 2020
Hematology
KAGAKU-HYORONNSHA CO., LTD. 2020

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Lectures and oral presentations (120)：

CML幹細胞の発生機構の解析
(第7回放射線災害・医科学研究拠点カンファランス 2023)
Lysophospholipid metabolism is essential for maintenance of CML stem cells
(The 95th Annual Meeting of the Japanese Biochemical Society 2022)
The lysophospholipid metabolism enzyme Gdpd3 maintains chronic myelogenous leukemia stem cells
(23rd Annual John Goldman E-Conference on Chronic Myeloid Leukemia: Biology and Therapy, 2021)
CML幹細胞の脂質代謝メカニズム
(第1回 Basic and Clinical Researcher 支援セミナー 2021)
The lysophospholipid metabolism enzyme Gdpd3 maintains chronic myelogenous leukemia stem cells
(FASEB Science Research Conference, The Lysophospholipid and Related Mediators Conference: From Bench to Clinic 2021)

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Education (2)：

Okayama University Graduate School of Engineering
Hiroshima University, Graduate School of Medicine.

Professional career (2)：

博士(医学) (広島大学)
修士(工学) (岡山大学)

Work history (7)：

2015/04/01 - Hiroshima University, Research Institute for Radiation Biology and Medicine Department of Stem Cell Biology Associate Professor
2015/04/01 - Hiroshima University, Research Institute for Radiation Biology and Medicine Department of Stem Cell Biology Associate Professor
2011/02/10 - 2015/03/31 Kanazawa University, Cancer Research Institute Exploratory Project on Cancer Stem Cells Associate Professor
2005/07/01 - 2011/02/09 Kanazawa University, Cancer Research Institute Division of Molecular Genetics Assistant Professor, and Associate Professor
2003/02/01 - 2005/06/30 Okayama University Graduate School of Medicine and Dentistry Department of Molecular Biology Post doctoral fellow, and Assistant Professor

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Awards (2)：

2018/02/13 - 大阪府商工労働部平成29年度創薬シーズ事業化コンペティション優秀賞平成29年度創薬シーズ事業化コンペティション
2011 - 日本白血病研究基金荻村孝特別研究賞

Association Membership(s) (3)：

The Japanese Society of Hematology , American Association for Cancer Research , Japanese Cancer Association

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