Eita Sasaki

ササキエイタ | Eita Sasaki

Affiliation and department：
Job title： Assistant Professor/Senior Assistant Professor
Homepage URL (1)： http://keio-analchem.jp

Research field (3)： Nanobioscience , Chemical biology , Bioorganic chemistry

Research keywords (5)： fluorescence probe , self-assembly , protein cage , chemical biology , protein engineering

Research theme for competitive and other funds (5)：

2024 - 2027 老化細胞特異的マーカーの網羅的探索と新規皮膚抗老化治療の開発
2022 - 2025 細菌のタンパク質コンパートメントを基にした機能性人工シェルの創成
2019 - 2022 メタボライト-シグナル連関による骨格筋恒常性維持機構の解明とその食品分野への応用
2019 - 2022 多様な自然抗体と食を起源とする抗原の相互作用に関する研究
2017 - 2019 Development of fluorescent probes for acrolein, a product of lipid peroxidation

Papers (31)：

Takashi Kubo, Tomoyuki Koike, Tomoki Ouchi, Nayab Khaliq, Eita Sasaki, Kouichi Kuroda, Mitsuyoshi Ueda, Kenjiro Hanaoka, Naoto Nemoto. In vitro selection of dye-fluorescence-enhancing peptide aptamer by cDNA display. Analytical Biochemistry. 2024. 115722-115722
Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, et al. A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT). Science advances. 2024. 10. 7. eadi8847
Hisashi Ohno, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka. Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging. Organic & Biomolecular Chemistry. 2024. 22. 16. 3099-3108
Mizuki Sugimoto, Eita Sasaki, Hisashi Ohno, Takayuki Ikeno, Sota Yamada, Kenjiro Hanaoka. Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT). Chemical and Pharmaceutical Bulletin. 2024. 72. 9. 810-816
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456

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MISC (1)：

Patents (6)：

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Books (2)：

“Chemical Approaches to Discover Selective Inhibitors of Sulfurtransferases and Transsulfuration Enzymes.” In Sulfurtransferases Essential Enzymes for Life
Elsevier 2023
クライオ電顕による小さなタンパク質の構造解析法 (実験医学)
羊土社 2018

Lectures and oral presentations (6)：

Development of selective inhibitors for sulfurtransferases and transsulfuration enzymes
(The 1st International G-ReXS Conference in Sendai 2024)
ケプラーは知っていた?クライオ電子顕微鏡で見えた意外な人工タンパク質ケージ構造
(NPO法人科学的根拠に基づく健康寿命を延ばす会第16回講演・研究会 2019)
多価アニオン性タンパク質ケージの自己集合と構造制御
(日本薬学会第138年会一般シンポジウム 2018)
機能性タンパク質ケージの自己集合と構造制御
(第14回レドックス・ライフイノベーションシンポジウム 2017)
Cryo-EM Structures of Highly Versatile Protein Containers
(Symposium in Scientific Networking Program 2016)

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Education (4)：

2005 - 2011 The University of Texas at Austin Department of Chemistry and Biochemistry
2005 - 2011 The University of Texas at Austin Department of Chemistry (PhD)
2003 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences (MS)
1999 - 2003 The University of Tokyo Faculty of Pharmaceutical Sciences (BS)

Professional career (2)：

Work history (8)：

2022/04 - 現在 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Lecturer / Senior Assistant Professor
2021/04 - 2022/03 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Project Lecturer
2017/04 - 2021/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant Proffesor
2014/04 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoctoral Fellow
2011/09 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoctoral Fellow

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