Rchr
J-GLOBAL ID：201801012041503315
Update date: Apr. 18, 2024
Eita Sasaki
ササキ エイタ | Eita Sasaki
Affiliation and department：
Job title：
Assistant Professor/Senior Assistant Professor
Homepage URL (1)：
http://keio-analchem.jp
Research field (3)：
Nanobioscience
, Chemical biology
, Bioorganic chemistry
Research keywords (5)：
fluorescence probe
, self-assembly
, protein cage
, chemical biology
, protein engineering
Research theme for competitive and other funds (4)：
- 2022 - 2025 細菌のタンパク質コンパートメントを基にした機能性人工シェルの創成
- 2019 - 2022 メタボライト-シグナル連関による骨格筋恒常性維持機構の解明とその食品分野への応用
- 2019 - 2022 多様な自然抗体と食を起源とする抗原の相互作用に関する研究
- 2017 - 2019 Development of fluorescent probes for acrolein, a product of lipid peroxidation
Papers (25)：
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Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, et al. A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT). Science advances. 2024. 10. 7. eadi8847
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Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456
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Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima, et al. General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process. Journal of the American Chemical Society. 2022. 144. 43. 19778-19790
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Recent Advances in Non-Viral Protein Shell Engineering and its Future. JSMI Report. 2022. 15. 2. 11-16
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Yuki Hoshino, Kenjiro Hanaoka, Kei Sakamoto, Masahiro Yasunaga, Takashi Kojima, Daisuke Kotani, Ayumu Nomoto, Eita Sasaki, Toru Komatsu, Tasuku Ueno, et al. Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity. RSC Chemical Biology. 2022. 3. 7. 859-867
ｍore...
MISC (4)：
Patents (4)：
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γ-グルタミルトランスペプチダーゼ5(GGT5)を検出する蛍光色素
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フタロシアニン色素およびその製造方法、並びにフタロシアニン色素を含む薬剤
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核酸検出用蛍光色素
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Preparation of 3,4-Diaminophenoxy Cyanine Dyes as Fluorescent Probes for Detection of Nitrogen Monoxide or Zinc Ions
Books (1)：
-
“Chemical Approaches to Discover Selective Inhibitors of Sulfurtransferases and Transsulfuration Enzymes.” In Sulfurtransferases Essential Enzymes for Life
Elsevier 2023
Education (4)：
- 2005 - 2011 The University of Texas at Austin Department of Chemistry and Biochemistry
- 2005 - 2011 The University of Texas at Austin Department of Chemistry (PhD)
- 2003 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences (MS)
- 1999 - 2003 The University of Tokyo Faculty of Pharmaceutical Sciences (BS)
Professional career (2)：
- Ph.D.
- Chemistry (The University of Texas at Austin)
Work history (9)：
- 2022/04 - 現在 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Lecturer / Senior Assistant Professor
- 2021/04 - 2022/03 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Project Lecturer
- 2017/04 - 2021/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant Proffesor
- 2014/04 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoctoral Fellow
- 2011/09 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoc
- 2012/04 - 2014/03 ETH Zurich Department of Chemistry and Applied Biosciences JSPS Postdoctoral Fellow for Research Abroad
- 2012/04 - 2014/03 JSPS Postdoctoral Fellow for Research Abroad
- 2011/09 - 2012/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Specially Appointed Researcher
- 2011/06 - 2011/08 The University of Texas at Austin College of Pharmacy Postdoc
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