Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (4)：
低分子量Gタンパク質
, 横紋筋融解症
, オートファジー
, スタチン
Research theme for competitive and other funds (7)：
2023 - 2026 ARLファミリー低分子量Gタンパク質群の活性制御機構と生理的役割の解析
2020 - 2023 細胞小器官の機能動態に介在するARLファミリー低分子量Gタンパク質群の解析
2017 - 2020 Analysis of physiological function and activation mechanism of atypical small GTPases
2014 - 2018 Analysis of activation mechanism and physiological function of ARL family small GTPases
2015 - 2017 Approaches for suppression of statins-induced rhabdomyolysis
2013 - 2015 Mechanism of statin-induced muscle cell death via the mTORC1 regulation pathway
2009 - 2010 Analysis of statin-induced autophagy and cell death in cell-type-specific manner
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Papers (19)：
Makoto Araki, Yukika Kasuya, Kaho Yoshimoto, Toshiaki Katada, Kenji Kontani. Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay. bioRxiv. 2024
Makoto Araki, Kenji Kontani. Analysis of the Guanine Nucleotide-Bound State of KRAS by Ion-Pair Reversed-Phase High-Performance Liquid Chromatography. Methods in molecular biology (Clifton, N.J.). 2024. 2797. 227-236
Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino. Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. Communications biology. 2023. 6. 1. 616-616
Tomohisa Yamamoto, Takeshi Tsuge, Makoto Araki, Masatomo Maeda. Cyclic AMP (cAMP)-dependent proteolysis of GATA6 by proteasome: Zinc-finger domain of GATA6 has signals for nuclear export and proteolysis, both of which are responsive to cAMP. Drug Discoveries & Therapeutics. 2023. 17. 1. 1-9
Makoto Araki, Kaho Yoshimoto, Meguri Ohta, Toshiaki Katada, Kenji Kontani. Development of a versatile HPLC-based method to evaluate the activation status of small GTPases. The Journal of biological chemistry. 2021. 101428-101428
