Satoru Kondo

コンドウサトル | Satoru Kondo

Affiliation and department：
Homepage URL (1)： http://otolaryngol.w3.kanazawa-u.ac.jp/

Research field (1)： Otorhinolaryngology

Research keywords (7)：中咽頭癌 , 頭頸部癌の発癌・転移機構 , 内因性免疫 , ヒト乳頭腫ウイルス , 上咽頭癌 , 頭頸部腫瘍 , Epstein Barr Virus

Research theme for competitive and other funds (23)：

2021 - 2025 EBウイルスによるDNAメチル化誘導機構の解明と新規上咽頭癌治療法の開発
2021 - 2024 新規生物学的コンセプトを応用した頭頸部ウイルス発癌超早期治療法の開発
2017 - 2021 Analysis of oncogenesis and heterogenesity in nasopharyngeal carcinoma and development of novel therapy
2017 - 2021 Elucidating the mechanism for induction of senescence-associated secretory phenotype by Epstein-Barr virus
2018 - 2019 エストロゲン受容体を介したヒト乳頭腫ウィルス関連中咽頭癌の発癌機序の解明

2016 - 2019 内因性免疫による頭頸部ウィルス発癌における内分泌撹乱物質の関与と新規治療法の開発

2015 - 2018 Association between activation induced cytidine deaminase and HPV positive oropharyngeal carcinogenesis

2014 - 2017 Therapeutic approach to recurrent respiratory papillomatosis from the perspective of signal transduction of human papillomavirus

2014 - 2017 Elucidation of mechansim to form pre-metastatic niche in nasopharyngeal carcinoma and development of exosome for its treatment

2014 - 2017 Analysis for the role of cell competition in the tumorigenesis and treatment strategy of nasopharyngeal carcinoma

2016 - 2017 Establishment tailor-made therapy of head and neck cancer by single cell analysis

2014 - 2016 A trial to isolate novel pathogenic viruses

2011 - 2015 The role of intrinsic immunity for EBV-mediated nasopharyngeal carcinogenesis

2013 - 2015 A master regulator, SATB1, regulates genes expressions in head and neck cancers

2012 - 2015 Establishment new therapy and analysis of carcinogenesis of nasopharyngeal carcinoma by cell competition

2011 - 2013 Cancer stem cell model and nasopharyngeal carcinogenesis

2009 - 2012 Research of the mechanism of lymph node metastasis in nasopharyngeal carcinoma with bio-assay model

2009 - 2011 Association of neck metastasis with tongue cancer stem cells.

2009 - 2010 ウィルスによる上咽頭癌幹細胞形成と上皮間葉移行の分子生物学的解析

2008 - 2010 New therapeutic approach for nasopharyngeal carcinoma using induction of Epstein-Barr virus lytic cycle by anti-cancer chemotherapy

2007 - 2010 Molecular biological analysis of Siah1 in EBV related tumor including nasopharyngeal cancer

2006 - 2009 EBV gene expression profile which is affected by virus reactivation and oncogenesis of nasopharyngeal carcinoma.

2007 - 2008 Association of single nucleotide polymorphism of MDM2 promoter in nasopharyngeal carcinoma patients

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Papers (127)：

Harue Mizokami, Atsushi Okabe, Ruchi Choudhary, Masato Mima, Kenta Saeda, Masaki Fukuyo, Bahityar Rahmutulla, Motoaki Seki, Boon-Cher Goh, Satoru Kondo, et al. Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma. eBioMedicine. 2024. 102. 105057-105057
Naohiro Wakisaka, Makiko Moriyama-Kita, Satoru Kondo, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Tomokazu Yoshizaki. Lymph node metastasis regulation by peritumoral tonsillar tissue mitochondria-related pathway activation in oropharyngeal cancer. PLOS ONE. 2024. 19. 2. e0299750-e0299750
Hirotomo Dochi, Satoru Kondo, Shigetaka Komura, Makiko Moriyama-Kita, Takeshi Komori, Asuka Nanbo, Miako Sakaguchi, Masaki Fukuyo, Toshihide Hamabe-Horiike, Mariko Tanaka, et al. Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: A poor prognostic marker. International journal of cancer. 2023
Naohiro Wakisaka, Makiko Moriyama-Kita, Satoru Kondo, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Tomokazu Yoshizaki. Immune-Related Gene Expression Profile at Peritumoral Tonsillar Tissue Is Modified by Oropharyngeal Cancer Nodal Status. The American journal of pathology. 2023
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, et al. Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma. International journal of cancer. 2023. 152. 9. 1847-1862

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MISC (127)：

美馬勝人, 岡部篤史, 中川拓也, 黒川友哉, 近藤悟, 溝上晴恵, 福世真樹, 繩井バハテヤリラヒムトラ, 星居孝之, 三澤清, et al. HPV挿入部位周辺のエピジェネティックな活性化による頭頸部扁平上皮癌発癌機構(Epigenetic activation of regions surrounding HPV integrated sites contributes to tumorigenesis of HNSCC). 日本癌学会総会記事. 2022. 81回. P-1293
美馬勝人, 溝上晴恵, 中川拓也, 黒川友哉, 近藤悟, 三澤清. HPV関連頭頸部扁平上皮癌に対する3次元クロマチン構造解析. 日本耳鼻咽喉科頭頸部外科学会会報. 2022. 125. 4. 749-749
美馬勝人, 岡部篤史, 中川拓也, 黒川友哉, 近藤悟, 溝上晴恵, 福世真樹, 縄井バハテヤリ・ラヒムトラ, 星居孝之, 三澤清, et al. 頭頸部扁平上皮癌においてHPV挿入が引き起こす発癌分子機構の解析. 日本癌学会総会記事. 2021. 80回. [P14-4]
Tomomi Aga, Kazuhira Endo, Akira Tsuji, Mitsuharu Aga, Makiko Moriyama-Kita, Takayoshi Ueno, Yosuke Nakanishi, Miyako Hatano, Satoru Kondo, Hisashi Sugimoto, et al. Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient. Journal of Otolaryngology of Japan. 2020. 123. 10. 1276-1277
近藤悟. 上咽頭癌の治療とバイオマーカー. 頭頸部癌. 2020. 46. 1. 1-4

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Lectures and oral presentations (18)：

Genome sequence analysis clarifies Epstein-Barr virus genome variations enhances clinicopathological features of nasopharyngeal cancer in non-endemic area, Japan.
(The International Symposium on EBV & KSHV & Related Agents and Diseases 2024)
ウイルス腫瘍の基礎研究-研究推進と研究費獲得のコツ-
(第48回日本頭頸部癌学会 2024)
Pathobiology of Epstein-Barr virus associated nasopharyngeal cancer
(Sino-Japanese Academic Symposium 2022)
Epstein-Barrウイルス感染と上咽頭癌
(第1回日本耳鼻咽喉科免疫アレルギー感染症学会 2021)
上咽頭癌の免疫療法の展望
(第38回日本耳鼻咽喉科免疫アレルギー学会 2020)

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Education (2)：

1999 - 2005 Kanazawa University
1993 - 1999 Kanazawa University

Professional career (1)：

医学博士 (金沢大学)

Work history (4)：

2016/11 - 現在 Kanazawa University Otorhinolaryngology & Head and Neck Surgery, Hospital
2011/04 - 2016/10 Kanazawa University Otorhinolaryngology & Head and Neck Surgery, Hospital
2007/04 - 2011/03 金沢大学医学部附属病院耳鼻咽喉科・頭頸部外科助教
2003/03 - 2005/03 米国ノースカロライナ大学ラインバーガー癌研究所客員研究員

Committee career (2)：

2023/04 - 現在日本耳鼻咽喉科免疫アレルギー感染症学会常任幹事
2014 - 2020 日本耳鼻咽喉科免疫アレルギー学会幹事

Awards (9)：

2023 - 頭頸部癌基礎研究会功労賞
2023 - 頭頸部癌基礎研究会優秀論文賞
2021 - 第1回日本耳鼻咽喉科免疫アレルギー感染症学会・学会賞
2018 - 金沢大学十全医学賞
2018 - 持田記念医学薬学振興財団研究助成代表

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Association Membership(s) (6)：

JAPAN SOCIETY FOR HEAD AND NECK SURGERY , JAPAN SOCIETY FOR HEAD AND NECK CANCER , JAPAN SOCIETY OF IMMUNOLOGY ALLERGOLOGY AND INFECTION IN OTOLARYNGOLOGY , 日本ウイルス学会 , THE JAPANESE CANCER ASSOCIATION , THE OTO-RHINO-LARYNGOLOGICAL SOCIETY OF JAPAN

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