Rchr
J-GLOBAL ID：201801012380736060   Update date: Jun. 21, 2024

Hattori Shinichiro

Hattori Shinichiro
Research field  (1)： Virology
Research theme for competitive and other funds  (2)：
  • 2020 - 2023 HIVとHBVの逆転写酵素の構造比較・解析を基盤とした新規抗HBV薬開発への応用
  • 2012 - 2012 HIV感染モデルマウスを用いたHIV感染早期におけるNK細胞の動態解明
Papers (69)：
  • Shogo Nakajima, Koichi Watashi, Takanobu Kato, Masamichi Muramatsu, Takaji Wakita, Noriko Tamura, Shin-Ichiro Hattori, Kenji Maeda, Hiroaki Mitsuya, Yoshiaki Yasutake, et al. Correction for Nakajima et al., "Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations". Journal of virology. 2024. 98. 3. e0182323
  • Arun K Ghosh, Monika Yadav, Satyanarayana Iddum, Somayeh Ghazi, Emma K Lendy, Uttara Jayashankar, Sydney N Beechboard, Yuki Takamatsu, Shin-Ichiro Hattori, Masayuki Aamano, et al. Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European journal of medicinal chemistry. 2024. 267. 116132-116132
  • 鍬田 伸好, 辻 耕平, 林 宏典, 石井 貴大, 小早川 拓也, 中野 堅太, 服部 真一朗, 岸本 直樹, 高宗 暢暁, 青木 宏美, et al. 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発. 日本エイズ学会誌. 2023. 25. 4. 428-428
  • Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-Ichiro Hattori, et al. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of medicinal chemistry. 2023. 66. 19. 13516-13529
  • Arun K Ghosh, Dana Shahabi, Mackenzie E C Imhoff, Satish Kovela, Ashish Sharma, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D Mesecar. SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads. Bioorganic & medicinal chemistry letters. 2023. 96. 129489-129489
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MISC (21)：
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Lectures and oral presentations  (3)：
  • 極めて強力な抗HIV活性を発揮する新規プロテアーゼ阻害剤GRL-142/KU-241の同定及びそのSIVmac251感染サルにおける抗ウイルス効果
    (日本エイズ学会誌 2018)
  • HIV潜伏感染細胞を標的とした新規治療薬開発に有効なin vitro評価系の開発
    (日本エイズ学会誌 2017)
  • Molecular simulation of EFdA and related analogs to determine the structural basis of HIV-1 drug resistance
    (Abstracts of Papers of the American Chemical Society 2017)
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