Hattori Shinichiro

Research field (1)： Virology

Research theme for competitive and other funds (2)：

2020 - 2023 HIVとHBVの逆転写酵素の構造比較・解析を基盤とした新規抗HBV薬開発への応用
2012 - 2012 HIV感染モデルマウスを用いたHIV感染早期におけるNK細胞の動態解明

Papers (65)：

Shin-ichiro Hattori, Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, et al. Structural and virologic mechanism of the emergence of resistance to M ^pro inhibitors in SARS-CoV-2. Proceedings of the National Academy of Sciences. 2024. 121. 37
Yoshiaki Yasutake, Shin-ichiro Hattori, Hiroki Kumamoto, Noriko Tamura, Kenji Maeda, Hiroaki Mitsuya. Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations. Scientific Reports. 2024. 14. 1
Arun K Ghosh, Monika Yadav, Satyanarayana Iddum, Somayeh Ghazi, Emma K Lendy, Uttara Jayashankar, Sydney N Beechboard, Yuki Takamatsu, Shin-Ichiro Hattori, Masayuki Aamano, et al. Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European journal of medicinal chemistry. 2024. 267. 116132-116132
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-Ichiro Hattori, et al. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of medicinal chemistry. 2023. 66. 19. 13516-13529
Arun K Ghosh, Dana Shahabi, Mackenzie E C Imhoff, Satish Kovela, Ashish Sharma, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D Mesecar. SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads. Bioorganic & medicinal chemistry letters. 2023. 96. 129489-129489

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MISC (33)：

篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, HAYDAR Bulut, et al. Development of small molecule inhibitors with potent antiviral activity targeting SARS-CoV-2 main protease. 日本薬学会年会要旨集(Web). 2024. 144th
篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, BULUT Haydar, et al. フッ素化及びチオアミド置換を活用した新規SARS-CoV-2メインプロテアーゼ阻害剤の創製. 日本薬学会関東支部大会講演要旨集(CD-ROM). 2023. 67th
高山彩光, 服部真一朗, 六本木誠, 満屋裕明, 紺野奇重. Synthesis of 4’-fluoro-carbocyclic adenosine targeting SARS-CoV-2 RNA polymerase. 日本薬学会年会要旨集(Web). 2023. 143rd
篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, BULUT Haydar, et al. Development of SARS-CoV-2 Main Protease Inhibitors by Fluorine Substitution and Amide Bond Conversion. 日本薬学会年会要旨集(Web). 2023. 143rd
石島花穂, 宮沢聖子, 服部真一朗, 六本木誠, 満屋裕明, 紺野奇重. Synthesis of 4’-fluoro-carbocyclic uridine derivatives targeting SARS-CoV-2 RNA polymerase. 日本薬学会年会要旨集(Web). 2023. 143rd

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Lectures and oral presentations (48)：

Synthesis of 4’-fluoro-carbocyclic adenosine targeting SARS-CoV-2 RNA polymerase
(日本薬学会年会要旨集(Web) 2023)
Development of SARS-CoV-2 Main Protease Inhibitors by Fluorine Substitution and Amide Bond Conversion
(日本薬学会年会要旨集(Web) 2023)
Synthesis of 4’-fluoro-carbocyclic uridine derivatives targeting SARS-CoV-2 RNA polymerase
(日本薬学会年会要旨集(Web) 2023)
ニルマトレルビルとその誘導体に耐性を示すSARS-CoV-2変異株の誘導と耐性獲得機序の解明
(日本エイズ学会誌 2023)
Nucleobase-Structure-activity relationship study of carbocyclic nucleosides as anti-SARS-CoV-2 agents
(日本薬学会年会要旨集(Web) 2022)

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