Hayashi Mikihito

ハヤシミキヒト | Hayashi Mikihito

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Oral medicine

Research keywords (2)：分子生物学 , 骨代謝学

Research theme for competitive and other funds (5)：

Papers (17)：

Anhao Liu, Mikihito Hayashi, Yujin Ohsugi, Sayaka Katagiri, Shizuo Akira, Takanori Iwata, Tomoki Nakashima. The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis. Nature Communications. 2024. 15. 1. 2707
Yu Yamashita, Mikihito Hayashi, Mitsuru Saito, Tomoki Nakashima. Osteoblast lineage cells-derived Sema3A regulates bone homeostasis independently of androgens. Endocrinology. 2022
Nasir K. Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, Hiroaki Suga. Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117. 49. 31070-31077
Yosuke Tsuchiya, Mikihito Hayashi, Katashi Nagamatsu, Takehito Ono, Masaki Kamakura, Takanori Iwata, Tomoki Nakashima. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. Journal of Biological Chemistry. 2020. 385. 34. 12224-12232
Yoshitaka Kameo, Yuki Miya, Mikihito Hayashi, Tomoki Nakashima, Taiji Adachi. In silico experiments of bone remodeling explore metabolic diseases andtheir drug treatment. Science Advances. 2020. 6. 10. eaax0938

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MISC (15)：

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Lectures and oral presentations (11)：

ローヤルゼリーに含まれる10-ヒドロキシ-2-デセン酸はFFAR4を介してNF-kB活性化および破骨細胞分化を抑制することで閉経後骨粗鬆症モデルマウスにおける骨量を維持する
(第42回日本炎症・再生医学会 2021)
ローヤルゼリー構成成分10-ヒドロキシ-2-デセン酸はFFAR4を介したNF-kB抑制により骨量減少を抑制する
(第6回日本骨免疫学会 2021)
Autoregulation of osteocyte Sema3A counteracts bone aging.
(Japan Bone Academy 2020 2020)
骨免疫と骨リモデリング制御
(第47回日本臨床免疫学会総会 2019)
Estrogen-miRNA-Sema3A-Nrp1 axis regulates bone mass through autoregulation of osteocyte
(第16回Bone Biology Forum 2019)

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Education (3)：

Professional career (1)：

Work history (6)：

2021/04 - 現在 Tokyo Medical and Dental University Department of Cell Signaling, Graduate School of Medical and Dental Sciences Associate Professor
2020/07 - 2021/03 Tokyo Medical and Dental University Department of Cell Signaling, Graduate School of Medical and Dental Sciences Assistant Professor
2018/04/01 - 2020/06/30 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Matrix Cell Signaling Assistant Professor
2013/06/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Matrix Cell Signaling Assistant Professor
2013/10/01 - 2015/03/31 科学技術振興機構 ERATO高柳オステオネットワークプロジェクトグループリーダー

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