Research theme for competitive and other funds (29)：
2024 - 2028 子宮内膜発がんにおける多段階発がんとがん多様性創出の分子機構解明
2024 - 2027 Establishment and analysis of human pancreatic acinar cell carcinoma cell lines to elucidate the pathogenesis of rare cancers and to explore new treatment methods.
2023 - 2026 Elucidation of the mechanisms underlying drug-resistance and identification of candidate drugs of gynecologic neuroendocrine tumors using patient-derived organoids
2023 - 2026 Elucidation of MYCN/NCYM function in outer radial glial cell
2023 - 2026 Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of predictive biomarker using patient-derived ovarian cancer organoids
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of therapeutic strategy of refractory cervical cancer using patient-derived organoids
2021 - 2024 Elucidation of genetic interactions underlying tumor development and metastasis using murine endometrial organoids
2021 - 2024 Elucidation of the mechanism underlying tumorigenesis and development of therapeutic strategy for uterine carcinosarcoma using murine and patient-derived organoids
2021 - 2024 NCYMによる分裂期制御機構とその神経芽腫発がんへの寄与の解明
2021 - 2024 Organoid-based modeling of gastric carcinogenesis and elucidation of its mechanism
2021 - 2024 Exploration of a novel therapeutic strategy of pancreatic cancers using organoid-based carcinogenesis model
2020 - 2023 Development of innovative treatment for glioblastoma targeting MYC family genes
2018 - 2023 Exploration of diagnostic markers targeting early-stage lesions of pancreatic carcinogenesis using novel organoid models.
2019 - 2022 An integrated study using patient-derived organoids toward elucidation of biological feature and development of therapeutic strategy of ovarian cancer
2019 - 2022 Research on carcinogenesis and cell differentiation using established human pancreatic acinar cell carcinoma cell line
2017 - 2020 Organoid-based Modeling of Endometrial Carcinogenesis
2017 - 2020 Integrative research on IPMN using organoids obtained from patients' pancreatic juice.
2016 - 2019 New Approach for Organoid Culture in Patients with Pancreatic Tumor
2015 - 2018 Revealing cancer-cell evolution and intra-tumor heterogeneity by single-cell genome and transcriptome analysis
2015 - 2017 Modeling for gastric carcinogenesis using normal gastric organoids
2014 - 2017 Lung carcinogenesis by genetic reconstitution using organoids derived from normal lung in mice
2014 - 2017 Elucidation of molecular mechanisms underlying colon carcinogenesis and discovery of therapeutic targets by using a novel in vitro model
2014 - 2016 Genetic reconstitution of pancreatic ductal carcinogenesis with murine primary cells
2004 - 2007 Systemic Analysis of transcriptional network in cancer
2005 - 2005 SNPアレイを用いたスキルス胃癌細胞株のゲノムコピー数解析
2003 - 2004 胃癌の分子標的に対する系統的モノクローナル抗体作成とその診断・治療への応用
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Papers (73)：
Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto. PGV-1 causes disarrangement of spindle microtubule organization resulting in aberrant mitosis in HLF and HuH6 cells associated with altered MYCN status. Advanced Pharmaceutical Bulletin. 2024
Yoshiaki Maru, Mami Kohno, Kiyomi Suzuka, Akiko Odaka, Mari Masuda, Akinobu Araki, Makiko Itami, Naotake Tanaka, Yoshitaka Hippo. Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer. Human cell. 2024
Assia Mouhand, Kazuma Nakatani, Fumiaki Kono, Yoshitaka Hippo, Tatsuhito Matsuo, Philippe Barthe, Judith Peters, Yusuke Suenaga, Taro Tamada, Christian Roumestand. 1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM. Biomolecular NMR assignments. 2024
Dhania Novitasari, Ikuko Nakamae, Noriko Yoneda-Kato, Jun-ya Kato, Yoshitaka Hippo, Yusuke Suenaga, Dyaningtyas Dewi Pamungkas Putri, Edy Meiyanto, Muthi’ Ikawati. The Combination of Sorafenib and PGV-1 Inhibits the Proliferation of Hepatocellular Carcinoma Through c-Myc Suppression in an Additive Manner: In Vitro Studies. Advances in Pharmacological and Pharmaceutical Sciences. 2024
Kazuma Nakatani, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yusuke Suenaga. Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance. Frontiers in oncology. 2024. 14. 1237378-1237378
